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We report the discovery of three pulsating subdwarf B stars in binary systems observed with the Kepler space telescope during Campaign 5 of K2. EPIC 211696659 (SDSS J083603.98+155216.4) is a g-mode pulsator with a white dwarf companion and a binary period of 3.16 d. EPICs 211823779 (SDSS J082003.35+173914.2) and 211938328 (LB 378) are both p-mode pulsators with main-sequence F companions. The orbit of EPIC 211938328 is long (635 ± 146 d) while we cannot constrain that of EPIC 211823779. The p modes are near the Nyquist frequency and so we investigate ways to discriminate super- from sub-Nyquist frequencies. We search for rotationally induced frequency multiplets and all three stars appear to be slow rotators with EPIC 211696659 subsynchronous to its orbit. [ABSTRACT FROM AUTHOR]

Objective:To compare the incidence of metabolic acidosis and feeding intolerance associated with powdered or acidified liquid human milk fortifier (HMF).Study Design:This retrospective study evaluated infants ⩽32 weeks gestational age or ⩽1500 g birth weight who received human milk with either powdered or acidified liquid HMF (50 consecutively born infants per group). Primary outcomes tracked were metabolic acidosis (base excess less than −4 mmol l−1 or bicarbonate less than 18 mmol l−1), feeding intolerance (gastric residual >50% feed volume, >3 loose stools or emesis per day, abdominal tenderness or distention), necrotizing enterocolitis, late-onset infection, death, length of hospital stay and ability to remain on HMF. Demographics, feeding practices, growth parameters and laboratory data were also collected.Result:Significantly more infants who received acidified liquid HMF developed metabolic acidosis (P<0.001). Base excess and bicarbonate were both significantly decreased after HMF addition in the liquid HMF group (base excess P=0.006, bicarbonate P<0.001). More infants were switched off liquid HMF due to metabolic acidosis or feeding intolerance than those on powdered HMF (P<0.001). Despite increased protein intake in the liquid HMF group (P=0.009), both groups had similar enteral caloric intakes with no difference in growth rates between the two groups. There was no significant difference in any of the other primary outcomes.Conclusion:Infants receiving acidified liquid human milk fortifier were more likely to develop metabolic acidosis and to be switched off HMF than those who received powdered HMF. Growth in the liquid HMF group was no different than the powdered group, despite higher protein intake. [ABSTRACT FROM AUTHOR]

Very little is known on how the humanistic burden of co-occurring major depressive disorder (MDD) and generalized anxiety disorder (GAD) compared to having either condition alone among patients with NCCDs. For each of the three cohorts, logistic regression models were used, to compare the burden of co-occurring MDD and GAD versus having MDD/GAD only, while controlling for patient socio-demographics. Among patients with 0 NCCDs, study outcomes did not differ significantly between those having co-occurring MDD and GAD versus MDD/GAD only. [Extracted from the article]

Generalized Anxiety Disorder (GAD) and/or Major Depressive Disorder (MDD) impact healthcare resource utilization (HCRU) and associated healthcare costs. A high frequency of patients with MDD and/or GAD had at least 3 or more NCCDs: MDD(49.9%), GAD(39.3%), and both MDD and GAD(51.7%). Analyses of HCRU showed that comorbid MDD and GAD was associated with significantly higher HCRU than MDD or GAD alone. [Extracted from the article]

Objective:To determine whether probiotics supplementation affects intestinal blood flow velocity in extremely low birth weight neonates.Study Design:In this randomized, double-blind, placebo-controlled study, probiotics were added to the first enteral feeding and continued until discharge or 34 weeks postmenstrual age. Pulsed Doppler was used to measure preprandial and postprandial (at 30 and 60 min) time-averaged mean velocity (TAMV), peak systolic velocity (PSV) and end diastolic velocity (EDV) during the second week of life after 7 days of probiotics supplementation.Result:A total of 31 infants were studied, 15 were randomized to the probiotic and 16 to the placebo groups. There was a significant postprandial increase in TAMV for the probiotic vs the placebo group (P=0.035), with PSV and EDV showing a trend. Demographic and clinical variables were similar between the groups.Conclusion:Probiotics administration significantly increases postprandial intestinal blood flow in extremely low birth weight preterm neonates when compared with the placebo group. [ABSTRACT FROM AUTHOR]