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2 results on '"Anna Ramunno"'

1. Correction to NewAnticancer Agents Mimicking Protein Recognition Motifs.

Author

Marco Persico, Anna Ramunno, Vita Maglio, Silvia Franceschelli, Chiara Esposito, Alfonso Carotenuto, Diego Brancaccio, Valeria De Pasquale, Luigi Michele Pavone, Michela Varra, Nausicaa Orteca, Ettore Novellino, and Caterina Fattorusso

Subjects
*ANTINEOPLASTIC agents, *PUBLISHED errata, *PERIODICAL articles, *PUBLISHING, *DRUG periodicals
Published
2015
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2. Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations.

Author

Stefania Butini, Margherita Brindisi, Sandro Cosconati, Luciana Marinelli, Giuseppe Borrelli, Salvatore Sanna Coccone, Anna Ramunno, Giuseppe Campiani, Ettore Novellino, Samantha Zanoli, Alberta Samuele, Gianluca Giorgi, Alberto Bergamini, Michela Di Mattia, Silvana Lalli, Bruno Galletti, Sandra Gemma, and Giovanni Maga

Subjects
*ANTIVIRAL agents, *DRUG resistance, *REVERSE transcriptase, *ENZYME inhibitors, *HIV, *BIOCHEMICAL mechanism of action, *GENETIC mutation, *MOLECULAR models
Abstract

Starting from the prototypic compound 4, we describe new, potent, and broad-spectrum pyrrolobenzo(pyrido)oxazepinones antivirals. A biochemical and enzymological investigation was performed for defining their mechanism of inhibition at either recombinant HIV-1 RT wild type and non-nucleoside reverse transcriptase inhibitors (NNRTIs)-resistant mutants. For the novel compounds (S)-(+)-5and (S)-(−)-7, a clear-cut stereoselective mechanism of enzyme inhibition was found. Molecular modeling studies were performed for revealing the underpinnings of this behavior. [ABSTRACT FROM AUTHOR]

Published
2009
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