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Background: Dexamethasone (DEXA) is commonly used to reduce brain swelling during neurosurgical procedures. DEXA, however, has many side-effects that can increase the risks of post-operative complications. In contrast, progesterone (PRO) has fewer side-effects and has been found to be neuroprotective on traumatic brain injury (TBI). Whether PRO may be used as an alternative to DEXA during routine procedures has not been fully explored. Object: To compare the effects of DEXA and PRO on surgical brain injury (SBI). Methods: Seventy-five adult male Sprague Dawley rats were randomized into five groups: (1) SBI + drug vehicle (peanut oil, 1 ml kg−1); (2) SBI + DEXA (1 mg kg−1); (3) SBI + low-dose PRO (10 mg kg−1); (4) SBI + high-dose PRO (20 mg kg−1); and (5) sham SBI + drug vehicle. Magnetic resonance imaging study and assessments of brain water content (BWC), blood-brain barrier (BBB) permeability, cellular inflammatory responses and matrix metalloproteinase 9 (MMP-9) expression were conducted. Results: This model consistently resulted in increased BWC and BBB disruption. PRO reduced astrocyte and microglia responses and attenuated brain oedema with preservation of BBB. A significant down-regulation of MMP-9 expression occurred in the PRO 20 group. Conclusions: PRO is as effective as DEXA in reducing brain oedema and inflammation following SBI; 10 mg kg−1 of PRO was demonstrated to be more effective in relieving acute cellular inflammatory responses. [ABSTRACT FROM AUTHOR]

We report the discovery of a new 21-cm HI absorption system using commissioning data from the Boolardy Engineering Test Array of the Australian Square Kilometre Array Pathfinder (ASKAP). Using the 711.5-1015.5 MHz band of ASKAP we were able to conduct a blind search for the 21-cm line in a continuous redshift range between z = 0.4 and 1.0, which has, until now, remained largely unexplored. The absorption line is detected at z = 0.44 towards the GHz-peaked spectrum radio source PKS B1740-517 and demonstrates ASKAP's excellent capability for performing a future wide-field survey for HI absorption at these redshifts. Optical spectroscopy and imaging using the Gemini-South telescope indicates that the HI gas is intrinsic to the host galaxy of the radio source. The narrow [OIII] emission lines show clear double-peaked structure, indicating either large-scale outflow or rotation of the ionized gas. Archival data from the XMM-Newton satellite exhibit an absorbed X-ray spectrum that is consistent with a high column density obscuring medium around the active galactic nucleus. The HI absorption profile is complex, with four distinct components ranging in width from 5 to 300 km s-1 and fractional depths from 0.2 to 20 per cent. In addition to systemic HI gas, in a circumnuclear disc or ring structure aligned with the radio jet, we find evidence for a possible broad outflow of neutral gas moving at a radial velocity of v ~ 300 km s-1. We infer that the expanding young radio source (tage 2500 yr) is cocooned within a dense medium and may be driving circumnuclear neutral gas in an outflow of ~1 M⊙ yr-1. [ABSTRACT FROM AUTHOR]

We present H I imaging of the galaxy group IC 1459 carried out with six antennas of the Australian Square Kilometre Array Pathfinder equipped with phased-array feeds. We detect and resolve H I in 11 galaxies down to a column density of ~1020 cm−2 inside a ~6 deg² field and with a resolution of ~1 arcmin on the sky and ~8 km s−1 in velocity. We present H I images, velocity fields and integrated spectra of all detections, and highlight the discovery of three H I clouds - two in the proximity of the galaxy IC 5270 and one close to NGC 7418. Each cloud has an H I mass of ~109 M⊙ and accounts for ~15 per cent of the H I associated with its host galaxy. Available images at ultraviolet, optical and infrared wavelengths do not reveal any clear stellar counterpart of any of the clouds, suggesting that they are not gas-rich dwarf neighbours of IC 5270 and NGC 7418. Using Parkes data, we find evidence of additional extended, low-column-density H I emission around IC 5270, indicating that the clouds are the tip of the iceberg of a larger system of gas surrounding this galaxy. This result adds to the body of evidence on the presence of intragroup gas within the IC 1459 group. Altogether, the H I found outside galaxies in this group amounts to several times 109 M⊙, at least 10 per cent of the H I contained inside galaxies. This suggests a substantial flow of gas in and out of galaxies during the several billion years of the group's evolution. [ABSTRACT FROM AUTHOR]

Circinus X-1 has recently returned to a state of strong radio flaring. Here we report on the first VLBI observations, and detection, undertaken in the 25 years since the 1975–1985 period of strong recurrent flaring activity. We detected Circinus X-1 with the first observations conducted by a recently developed Southern hemisphere e-VLBI array, at both 1.6 and 8.4 GHz, over a three-day period. At 1.6 GHz, the compact source has a total flux density of 11 mJy and a size of 60 ± 15 mas (Gaussian model full width at half maximum). At 8.4 GHz, the compact source is less than 60 mas. The size variation with frequency is consistent with a broadened image due to scattering in the turbulent, ionized interstellar medium of our Galaxy. However, these size measurements appear inconsistent with the λ2.2 variation expected for strong interstellar scattering and previous VLBI observations made at 2.3 GHz in the early 1980s. To explain this apparent inconsistency, we suggest that Circinus X-1 supports a weak, non-varying component of 35 mas extent (175 au at 5 kpc distance), corresponding to compact structure in the extended radio nebula. No significant variation in the flux density at 1.6 GHz is evident between two observations 24 h apart. No jet-like structures are evident on scales of tens of mas, simply a scatter broadened source, presumably coincident with the suggested neutron star in the binary system. [ABSTRACT FROM AUTHOR]