1. Impaired respiratory function reduces haemoglobin oxygen affinity in COVID‐19.
- Author
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Bergamaschi, Gaetano, Barteselli, Chiara, Del Rio, Virginia, Borrelli de Andreis, Federica, Pellegrino, Ivan, Mengoli, Caterina, Miceli, Emanuela, Colaneri, Marta, Zuccaro, Valentina, Di Stefano, Michele, Bruno, Raffaele, Di Sabatino, Antonio, Abruzzese, Giulia Maria, Achilli, Giovanna, Alimenti, Eleonora, Alunno, Giacomo, Antoci, Valentina, Aprile, Marco, Argelli, Alice, and Aronico, Nicola
- Subjects
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LACTATES , *HEMOGLOBINS , *MYOCARDIAL infarction , *COVID-19 , *BUTORPHANOL - Abstract
Impaired respiratory function reduces haemoglobin oxygen affinity in COVID-19 Keywords: COVID-19; haemoglobin-oxygen affinity; haemoglobin P50; oxyhaemoglobins; PaO2 to fraction of inspired oxygen ratio; SARS-CoV-2 EN COVID-19 haemoglobin-oxygen affinity haemoglobin P50 oxyhaemoglobins PaO2 to fraction of inspired oxygen ratio SARS-CoV-2 e44 e47 4 02/21/23 20230301 NES 230301 Using homology modelling and molecular docking algorithms, Liu and Li predicted the existence of interactions between SARS-Cov-2 and haemoglobin (Hb) and suggested that these interactions may change haemoglobin-oxygen (Hb-O SB 2 sb ) affinity.[1] Hb-O SB 2 sb affinity has been extensively studied in intensive care unit (ICU) patients with COVID-19 (usually intubated and mechanically ventilated) showing normal to increased affinity.[[2], [4]] Higher Hb-O SB 2 sb affinity facilitates Hb oxygenation in the lungs while reducing tissue O SB 2 sb unloading; a reduced Hb-O SB 2 sb affinity has the opposite effect. COVID-19, haemoglobin-oxygen affinity, haemoglobin P50, oxyhaemoglobins, PaO2 to fraction of inspired oxygen ratio, SARS-CoV-2. [Extracted from the article]
- Published
- 2023
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