1. Urinary megalin in association with progression factors of diabetic nephropathy.
- Author
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Akour, A., Kasabri, V., Bulatova, N., Al-Motassem, Y., Fahmawi, H., Momani, M., Zayed, A., Alquoqa, R., and AlHawari, H.
- Subjects
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MEGALIN , *DIABETIC nephropathies , *BLOOD pressure , *GLYCEMIC control , *VITAMIN D , *GLYCOSYLATED hemoglobin , *TRIGLYCERIDES - Abstract
AIM: The aim of this study is to evaluate the association between urinary megalin, renal function, blood pressure, lipid profile, vitamin D and glycemic control in patients with type 2 diabetes mellitus (T2DM). METHODS:. This was a cross-sectional study which recruited 209 patients with T2DM. Urinary megalin was positively associated with systolic blood pressure (SBP) (r=0.218, p=0.04) but negatively with glomerular filtration rate (GFR) (r=-0.16, p=0.023). The levels of urinary albumin, triglycerides (TGs) and glycosylated hemoglobin (HbA1c) were higher in the “high-megalin" group, compared to those in “low-megalin" group. Moreover, there was a signifi cant inverse association between vitamin D3 levels and megalin levels in urine (OR=0.281, p=0.047). CONCLUSION: Our study showed for the first time that megalin is associated with progression factors of diabetic nephropathy as well as vitamin D deficiency. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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