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This document, published in the Journal of Applied Physics, discusses the importance of multiscale modeling and analysis in the field of biophysics. The authors emphasize the need for tools and analyses that integrate across physical scales and time scales in order to advance medical science. The document includes a collection of studies on various topics such as cardiac biomechanics, tissue mechanics, cerebral fluid flow, cell mechanics, protein modeling, and molecular fluorescence microscopy. The authors hope that readers will find these studies informative and inspiring. [Extracted from the article]

Simple Summary: Ireland's political engagement with animal protection has evolved significantly between 2011 and 2020, reflecting growing societal concerns about animal welfare and biodiversity. This study analysed election manifestos from Ireland's main political parties during this period, examining how these issues have gained prominence. Key topics include farmed animal welfare, wildlife conservation, and the economic and ethical dimensions of horse and greyhound racing. While progressive parties such as the Greens consistently advocated for strong animal welfare policies, centrist parties such as Fianna Fáil and Fine Gael gradually adopted more positive stances, albeit often with an economic focus. Despite this progress, critical issues such as the puppy trade, livestock welfare, and sustainable farming practices remain underrepresented. This study highlights a growing public and political recognition of the importance of animal welfare, with implications for future policy development. As awareness increases, there is potential for more robust legislative action to address gaps and strengthen protections for animals and ecosystems. This research, the first of its kind in Ireland, sheds light on the political dynamics surrounding animal welfare and their alignment with societal values. It provides a foundation for understanding how public sentiment influences policy and underscores the importance of continued advocacy and research in this field. Ireland is the largest beef trader and a major dairy exporter within the European Union. Horse racing holds significant cultural value, while greyhound racing is economically important at the regional level. As public concern about farm animal welfare rises and biodiversity loss intensifies, this research examines the political salience of animal protection in Ireland across the 2011, 2016, and 2020 general elections. Political salience measures the degree of public concern about political issues, with party manifestos serving as indicators of this concern. Using both quantitative and qualitative methods, this study analysed 364 statements on animal protection from Fianna Fáil, Fine Gael, the Green Party, the Labour Party, and Sinn Féin. The results show a significant increase in the frequency and positivity of animal protection statements over the course of the election period, with a shift in the attitudes of Fianna Fáil and Fine Gael. The Green Party has consistently promoted progressive animal protection policies. Key issues such as farmed animal welfare, wildlife and biodiversity, and horse and greyhound racing have gained prominence in party manifestos, also reflecting economic influences. Despite this growing focus, critical issues such as the puppy trade and certain aspects of farmed animal welfare remain underrepresented. This research provides the first comprehensive academic analysis of animal protection policy in political party manifestos in the Republic of Ireland. [ABSTRACT FROM AUTHOR]

Dirac fluids--interacting systems obeying particle-hole symmetry and Lorentz invariance--are among the simplest hydrodynamic systems; they have also been studied as effective descriptions of transport in strongly interacting Dirac semimetals. Direct experimental signatures of the Dirac fluid are elusive, as its charge transport is diffusive as in conventional metals. In this paper, we point out a striking consequence of fluctuating relativistic hydrodynamics: The full counting statistics (FCS) of charge transport is highly non-Gaussian. We predict the exact asymptotic form of the FCS, which generalizes a result previously derived for certain interacting integrable systems. A consequence is that, starting from quasi-one-dimensional nonequilibrium initial conditions, charge noise in the hydrodynamic regime is parametrically enhanced relative to that in conventional diffusive metals. [ABSTRACT FROM AUTHOR]

A trait labelled as "morality" has been argued to be perceived and prioritised during first impressions of faces; however, immorality is not a homogenous concept. Violations of purity are frequently distinguished from other violations via distinct behavioural and emotional patterns, arguably stemming from physical disgust, sexual content, or "weirdness" impure scenarios. In the current research, participants were asked to rate unfamiliar faces based on social traits and their likelihood of engaging in immoral or nonmoral behaviours. Across two studies, perceived engagement in most autonomy and purity moral violations but also the non-moral sexual and "weird" acts was predicted by lower facial morality. There was also a distinction wherein most purity violations and physical disgust were more associated with male gender, and most autonomy violations with ratings of high dominance. The scenarios also differed within categories, such as sexually impure scenarios and disgust associated with unattractive faces; while behaving "weirdly" and certain other purity violations were associated with low dominance. Taken together, our results suggest faces seemingly low on the trait labelled "morality" are perceived as more likely to engage in most immoral behaviours, but also in other socially relevant, nonmoral behaviours. Social judgements are also not homogenous within or between theory-based categories of moral violations. [ABSTRACT FROM AUTHOR]

Exposed and isolated alpine ecosystems present evolutionary challenges for flying species worldwide. Many insects have undergone dramatic wing reduction in response to these harsh conditions, losing the ability to fly. By contrast, some taxa have countered alpine conditions by evolving larger wings to improve flight ability. In this study, we investigated how two independent clades of Zelandoperla fenestrata stoneflies respond to upland environments. Our results revealed strikingly different adaptations to elevation across the two closely related clades. In Clade 1 (southern South Island), wing length decreases sharply with increasing elevation. In contrast, wing length in the geographically adjacent Clade 2 (northern South Island, and North Island) increases with elevation. These contrasting strategies highlight the diverse adaptive pathways that may exist even for closely related lineages encountering similar environmental challenges. [ABSTRACT FROM AUTHOR]

Rapid adaptation is thought to be critical for the survival of species under global change, but our understanding of human-induced evolution in the wild remains limited. We show that widespread deforestation has underpinned repeated color shifts in wild insect populations. Specifically, loss of forest has led to color changes across lineages that mimic the warning coloration of a toxic forest stonefly. Predation experiments suggest that the relative fitness of color phenotypes varies between forested and deforested habitats. Genomic and coloration analyses of 1200 specimens show repeated selection at the ebony locus controlling color polymorphism across lineages. These findings represent an example of human-driven evolution linked to altered species interactions, highlighting the possibility for populations to adapt rapidly in the wake of sudden environmental change. [ABSTRACT FROM AUTHOR]

Background: The COVID-19 pandemic led to dramatic changes in the lives of children that impact cardiometabolic health. Cities and counties had varying policies with respect to school closure, recreational programs, and efforts to mitigate food insecurity and economic distress. Our objective was to evaluate changes in BMI-z score and prevalence of overweight/obesity prior to and during the pandemic among children in San Francisco, CA, where public schools were closed for 18-months. Methods: This was an electronic medical record-based retrospective cohort study. We included 15,401 children, 4–17 years of age at study onset. Our exposure was time into each of three time periods: (1) March 2018-February 2019; (2) March 2019-February 2020; (3) March 2020-August 2021 (the pandemic period of school closure). Generalized estimating equations (GEE) were used to assess changes in BMI-z score and overweight/obesity across the three time periods. We assessed for effect modification by age-category, insurance status, and race/ethnicity. Results: Mean BMI-z score increased by 0.06 per year in time period 2, the year prior to the pandemic (p < 0.001, 95% CI: 0.04, 0.09), and by 0.12 per year during time period 3, the first 18 months of the pandemic (p < 0.001, 95% CI 0.10, 0.13). The proportion of children with overweight/obesity increased by 1.4% points per year during time period 2 (p = 0.012, 95% CI: 0.03, 2.46) and by 4.9% points per year during the first 18 months of the pandemic (p < 0.001, 95% CI: 4.11, 5.67). The effect modification analysis demonstrated that the youngest age group, publicly insured children (versus privately insured), and Black, Latino, and Asian children (versus White children) experienced greater increases in BMI-z score during the pandemic (p < 0.01 for all comparisons). The youngest age group (p = 0.022) and publicly insured children (versus privately insured children) (p < 0.001) also experienced greater increases in the proportion of children with overweight/obesity during the pandemic. Conclusions: Among children in San Francisco, increases in BMI-z score and overweight/obesity were greater during the pandemic compared to prior changes, with the most pronounced increases among younger and publicly insured children. These findings support the need for more targeted and effective policies for addressing childhood overweight/obesity, especially among these high-risk populations. [ABSTRACT FROM AUTHOR]

Rapid adaptation is thought to be critical for the survival of species under global change, but our understanding of human-induced evolution in the wild remains limited. We show that widespread deforestation has underpinned repeated color shifts in wild insect populations. Specifically, loss of forest has led to color changes across lineages that mimic the warning coloration of a toxic forest stonefly. Predation experiments suggest that the relative fitness of color phenotypes varies between forested and deforested habitats. Genomic and coloration analyses of 1200 specimens show repeated selection at the ebony locus controlling color polymorphism across lineages. These findings represent an example of human-driven evolution linked to altered species interactions, highlighting the possibility for populations to adapt rapidly in the wake of sudden environmental change. [ABSTRACT FROM AUTHOR]

Simple Summary: Zoo professionals and volunteers care for numerous animals, creating the potential for exposure to multiple deaths and transfer-related losses. Despite this, there is limited research exploring how zoo professionals and volunteers experience and adapt to zoo animal loss. This qualitative study was designed to explore the personal experiences of zoo animal loss among zoo professionals and volunteers, including their emotional challenges, coping mechanisms, and support-related needs. We found participants' responses highlighted two main themes: the lasting toll of animal-related loss and their interpersonal experience of loss. Within these themes, zoo professionals and volunteers' responses provided insights into experiences related to deaths (both expected and unexpected), transfer losses, experiences of complicated grief, and interpersonal factors that interfered with their ability to process their loss. Participants' suggestions for support when faced with these experiences included enhanced communication before pending losses and following deaths and transfers, environments conducive for memorializing rituals, and increased access to grief support resources. Zoo professionals and volunteers play essential roles in the wellbeing and conservation of a diverse array of animal species. Despite the growing body of literature revealing the psychological impacts of pet loss, there remains a dearth of information describing the experience of animal loss among those who work in zoo settings. This qualitative study explored the personal experiences of zoo animal loss among volunteers (n = 12), animal care and health professionals (ACHPs) (n = 135), and other zoo staff (n = 35) who participated in a larger mixed-method study. Participants responded to five open-ended questions exploring their most significant zoo animal death loss, where or from whom they found the most support, how the zoo community could better support them, advice for zoo leaders, and other thoughts about their grief and animal-related loss experiences. Using thematic analysis, two key themes were identified: the lasting toll of zoo animal loss and zoo professionals' and volunteers' interpersonal experiences. Participants described their experiences with animal transfers and both expected and unexpected deaths. Requests for support focused on better communication, grief resources, and opportunities to recognize and mourn animal losses. These findings suggest that zoo animal loss can negatively impact zoo professionals' and volunteers' psychological health. [ABSTRACT FROM AUTHOR]

Assess dog owners' concern levels and veterinary care decisions pertaining to behaviors that might signify pain before and after receiving brief pain-related educational information. Additionally, evaluate dog owners' perceptions of a modified version of the Colorado State University Canine Acute Pain Scale to identify their dog's pain level, determine whether they should take their dog to the veterinarian, and describe their dog's pain to their veterinarian. SAMPLE 367 survey respondents who resided in the US and were the primary caretaker of at least 1 dog. METHODS An electronic survey was created in Qualtrics and distributed via Prolific. Data were analyzed. RESULTS When assessing differences between participants' concern levels before and after educational pain-related information, significant differences were found for 2 of the 3 scenarios. Significant differences were also found between participants' veterinary-related behaviors before and after educational pain-related information for all 3 scenarios. The most common reasons for not seeking immediate veterinary care included elements related to cost, convenience, and dog-related stress during veterinary visits. Most participants reported finding the Canine Acute Pain Scale useful for identifying their dog's pain level (89%), determining whether they should take their dog to the veterinarian (84%), and describing their dog's pain to their veterinarian (89%). CLINICAL RELEVANCE Owners' interpretations of and subsequent actions (or inactions) to behaviors that might suggest pain carry great implications for companion animals' overall well-being. Following exposure to brief educational material about signs and symptoms of canine pain, owners in our study reported significant increases in stated concern related to their dog's change in behavior and intention to seek veterinary care. These findings suggest that even very brief pain related educational material can have a positive impact on owners' perceptions of canine behavioral changes and increase the possibility that they will seek veterinary care. [ABSTRACT FROM AUTHOR]

This research uses an online questionnaire (n = 1148) to survey the Bulgarian public's attitudes and behaviors toward owned and stray cats and explore potential barriers to stray cat population management. Generally, the survey participants indicated positive attitudes toward stray cats, with 82.0% of the respondents reporting feeling sorry for stray cats. Semi-ownership behaviors were prevalent, with 82.5% feeding stray cats but only 18.1% neutering the cats they fed, posing a barrier to stray cat management. Overall, the respondents held mixed attitudes toward neutering. Of all cat owners sampled (n = 859) only 47.2% had neutered all their cats and 44.4% of owners allowed cats outdoor access or their cats lived exclusively outdoors. Multinomial logistic regression predicted that intact cats were more likely to be allowed to roam free and reproduce, which may present a significant barrier to stray cat population management. This is the first academic survey on attitudes toward cats in Bulgaria and the findings should contribute to stray cat management and ultimately improve feline welfare. [ABSTRACT FROM AUTHOR]

Antibiotic resistance is a major public health threat, and alternatives to antibiotic therapy are urgently needed. Immunotherapy, particularly the blockade of inhibitory immune checkpoints, is a leading treatment option in cancer and autoimmunity. In this study, we used a murine model of Salmonella Typhimurium infection to investigate whether immune checkpoint blockade could be applied to bacterial infection. We found that the immune checkpoint T‐cell immunoglobulin and ITIM domain (TIGIT) was significantly upregulated on lymphocytes during infection, particularly on CD4+ T cells, drastically limiting their proinflammatory function. Blockade of TIGIT in vivo using monoclonal antibodies was able to enhance immunity and improve bacterial clearance. The efficacy of anti‐TIGIT was dependent on the capacity of the antibody to bind to Fc (fragment crystallizable) receptors, giving important insights into the mechanism of anti‐TIGIT therapy. This research suggests that targeting immune checkpoints, such as TIGIT, has the potential to enhance immune responses toward bacteria and restore antibacterial treatment options in the face of antibiotic resistance. [ABSTRACT FROM AUTHOR]

Charcot–Marie–Tooth type 1B (CMT1B) is a peripheral neuropathy caused by mutations in the gene encoding myelin protein zero (MPZ), a key component of the myelin sheath in Schwann cells. Mutations in the MPZ gene can lead to protein misfolding, unfolded protein response (UPR), endoplasmic reticulum (ER) stress, or protein mistrafficking. Despite significant progress in understanding the disease mechanisms, there is currently no effective treatment for CMT1B, with therapeutic strategies primarily focused on supportive care. Gene therapy represents a promising therapeutic approach for treating CMT1B. To develop a treatment and better design preclinical studies, an in-depth understanding of the pathophysiological mechanisms and animal models is essential. In this review, we present a comprehensive overview of the disease mechanisms, preclinical models, and recent advancements in therapeutic research for CMT1B, while also addressing the existing challenges in the field. This review aims to deepen the understanding of CMT1B and to encourage further research towards the development of effective treatments for CMT1B patients. [ABSTRACT FROM AUTHOR]

Background: Dialysis is lifesaving for acute kidney injury (AKI), but access is poor in less resourced settings. A "peritoneal dialysis (PD) first" policy for paediatric AKI is more feasible than haemodialysis in low-resource settings. Methods: Retrospective review of modalities and outcomes of children dialysed acutely at Red Cross War Memorial Children's Hospital between 1998 and 2020. Results: Of the 593 children with AKI who received dialysis, 463 (78.1%) received PD first. Median age was 9.0 (range 0.03–219.3; IQR 13.0–69.6) months; 57.6% were < 1 year old. Weights ranged from 0.9 to 2.0 kg (median 7.0 kg, IQR 3.0–16.0 kg); 38.6% were < 5 kg. PD was used more in younger children compared to extracorporeal dialysis (ECD), with median ages 6.4 (IQR 0.9–30.4) vs. 73.9 (IQR 17.5–113.9) months, respectively (p = 0.001). PD was performed with Seldinger soft catheters (n = 480/578, 83%), predominantly inserted by paediatricians at the bedside (n = 412/490, 84.1%). Complications occurred in 127/560 (22.7%) children receiving PD. Overall, 314/542 (57.8%) children survived. Survival was significantly lower in neonates (< 1 month old, 47.5%) and infants (1–12 months old, 49.2%) compared with older children (> 1 year old, 70.4%, p < 0.0001). Survival was superior in the ECD (75.4%) than in the PD group (55.6%, p = 0.002). Conclusions: "PD First for Paediatric AKI" is a valuable therapeutic approach for children with AKI. It is feasible in low-resourced settings where bedside PD catheter insertion can be safely taught and is an acceptable dialysis modality, especially in settings where children with AKI would otherwise not survive. [ABSTRACT FROM AUTHOR]

We must ensure that we do not sacrifice patient safety and proper training when exploring technological advancements in surgery. [ABSTRACT FROM AUTHOR]

Statistical models incorporating cluster-specific intercepts are commonly used in hierarchical settings, for example, observations clustered within patients or patients clustered within hospitals. Predicted values of these intercepts are often used to identify or "flag" extreme or outlying clusters, such as poorly performing hospitals or patients with rapid declines in their health. We consider a variety of flagging rules, assessing different predictors, and using different accuracy measures. Using theoretical calculations and comprehensive numerical evaluation, we show that previously proposed rules based on the 2 most commonly used predictors, the usual best linear unbiased predictor and fixed effects predictor, perform extremely poorly: the incorrect flagging rates are either unacceptably high (approaching 0.5 in the limit) or overly conservative (eg, much <0.05 for reasonable parameter values, leading to very low correct flagging rates). We develop novel methods for flagging extreme clusters that can control the incorrect flagging rates, including very simple-to-use versions that we call "self-calibrated." The new methods have substantially higher correct flagging rates than previously proposed methods for flagging extreme values, while controlling the incorrect flagging rates. We illustrate their application using data on length of stay in pediatric hospitals for children admitted for asthma diagnoses. [ABSTRACT FROM AUTHOR]

We present a framework for identifying when conditions are favourable for transmission of vector‐borne diseases between communities by incorporating predicted disease prevalence mapping with landscape analysis of sociological, environmental and host/parasite genetic data. We explored the relationship between environmental features and gene flow of a filarial parasite of humans, Onchocerca volvulus, and its vector, blackflies in the genus Simulium. We generated a baseline microfilarial prevalence map from point estimates from 47 locations in the ecological transition separating the savannah and forest in Ghana, where transmission of O. volvulus persists despite onchocerciasis control efforts. We generated movement suitability maps based on environmental correlates with mitochondrial population structure of 164 parasites from 15 communities and 93 vectors from only four sampling sites, and compared these to the baseline prevalence map. Parasite genetic distance between sampling locations was significantly associated with elevation (r =.793, p =.005) and soil moisture (r =.507, p =.002), while vector genetic distance was associated with soil moisture (r =.788, p =.0417) and precipitation (r =.835, p =.0417). The correlation between baseline prevalence and parasite resistance surface maps was stronger than that between prevalence and vector resistance surface maps. The centre of the study area had high prevalence and suitability for parasite and vector gene flow, potentially contributing to persistent transmission and suggesting the importance of re‐evaluating transmission zone boundaries. With suitably dense sampling, this framework can help delineate transmission zones for onchocerciasis and would be translatable to other vector‐borne diseases. [ABSTRACT FROM AUTHOR]

Background: Acute post-streptococcal glomerulonephritis (APSGN) is the most common cause of acute nephritis in children globally and, in some cases, may be associated with progressive kidney injury and failure, cumulating in the need for long-term dialysis and/or kidney transplantation. Methods: Our retrospective study describes the occurrence of APSGN among children (< 14 years) admitted to a tertiary children's hospital in Cape Town, South Africa, from January 2015 to December 2020. Results: Of 161 children who presented with acute nephritis (haematuria, oedema, oliguria, and hypertension), 100 met the inclusion criteria. Demographic, clinical features, laboratory findings, management, and outcome data were collected. APSGN was defined by the clinical presentation of at least two clinical signs of acute nephritis, and low serum complement 3 (C3) level or evidence of a recent streptococcal infection. Most cases of APSGN were associated with streptococcal skin infections: 55/100 (55%); 10/100 (10%) children presented with hypertensive seizures; C3 levels were low in 86/92 (93.5%) children; 94/94 (100%) children had elevated anti-deoxyribonuclease-B (anti-DNase-B) levels; and 80/94 (85%) also had elevated anti-streptolysin O titre (ASOT) at presentation. Eleven (11%) children had a percutaneous kidney biopsy; 4/11 (36%) showed histological features of post-infectious nephritis, and 7/11(64%) also had crescentic glomerulonephritis with immune complex deposits. Sixty-two (62%) children confirmed recovered, and five (5%) progressed to kidney failure, but 29 presumed recovered as they did not return for follow-up to our institution. Conclusions: Childhood APSGN remains an important health problem in South Africa (SA) with favourable outcomes in most, apart from those with crescentic glomerulonephritis who progressed to kidney failure. [ABSTRACT FROM AUTHOR]

Although there has been considerable post hoc research on student views of supervisors, there is little on how candidate expectations are constituted at or close to the point of commencement. This study reads students' commentary about the 'ideal supervisor' at the point of institutional induction to examine commencing candidate expectations, concluding that student discourse reflects historical, guild notions of the supervisor as 'master', and institutional messaging about the primary responsibility of the supervisor for positive research degree outcomes. The 'ideal' supervisor imagined by commencing candidates possesses highly esteemed character virtues and research mastery such that they can meet all needs and guarantee a successful outcome and a positive candidate experience. The paper concludes that institutional representations of the supervisor role need to change to re-situate supervision within wider networks of engagement and support and this needs to be reflected in the design of institutional orientation. [ABSTRACT FROM AUTHOR]

Commencing study for a PhD or other higher degree by research (HDR) constitutes a significant educational transition. To date, little research has been undertaken on the orientation or induction experiences of commencing HDR candidates and there is little guidance for HE providers of induction. This paper reflects upon understandings of student transition within the HE literature highlighting the role played by the sociocultural context surrounding research in shaping commencing candidates’ expectations. The paper argues that candidate expectations at the point of transition into the research degree reflect prevailing sociocultural norms about what it means to be a doctoral student. We also share a pedagogical strategy that can be used at induction events to reveal and to engage candidates in an exploration of the underlying experiential templates they bring to their upcoming degree experience. [ABSTRACT FROM AUTHOR]

At the time of writing, confirmed UK deaths from COVID-19 number over 160,000. While the restrictions on burial rituals and closure of faith spaces during successive UK lockdowns have impacted the commemoration of COVID-19 victims, the emergence of grassroots memorial practices – from street art campaigns to yellow hearts in the windows of bereaved households – demonstrates the extent to which communities have adapted ceremonial processes in a period of national trauma. This visual essay examines a selection of grassroots activities, created both during and between UK lockdowns, charting the way in which apparently coherent aesthetic approaches to COVID-19 memorialisation provide cover for diverse political and personal agendas. [ABSTRACT FROM AUTHOR]

The squeezed limit of the primordial curvature bispectrum is an extremely sensitive probe of new physics and encodes information about additional fields active during inflation such as their masses and spins. In the conventional setup, additional fields are stable with a positive mass squared, and hence induce a decreasing signal in the squeezed limit, making a detection challenging. Here we consider a scalar field that is temporarily unstable by virtue of a transient tachyonic mass, and we construct models in which it is embedded consistently within inflation. Assuming IR-finite couplings between the tachyon and the inflaton, we find an exchange bispectrum with an enhanced long-short scale coupling that grows in the squeezed limit parametrically faster than local non-Gaussianity. Our approximately scale-invariant signal can be thought of as a cosmological tachyon collider. In a sizeable region of parameter space, the leading constraint on our signal comes from the cross correlation of μ-type spectral distortions and temperature anisotropies of the microwave background, whereas temperature and polarization bispectra are less sensitive probes. By including anisotropic spectral distortions in the analysis, future experiments such as CMB-S4 will further reduce the allowed parameter space. [ABSTRACT FROM AUTHOR]

Consociationalism is often perceived as a go-to response to ethnicized conflict, a form of 'political prescription' proffered by both external mediators and domestic constitutional designers alike. Power-sharing theory posits that extended periods of cross-community cooperation can lessen divisions, allowing the system to give way to more 'normal' politics. However, increasing evidence from Lebanon and elsewhere tracks a different set of incentives. Rather than facilitating a virtuous cycle of cooperation and consensus, a more vicious cycle of immobilism, intransigence, and institutional collapse emerges. In Lebanon, this has coincided with a set of intersecting political, economic, and humanitarian crises. This paper outlines how consociationalism's causal logic has undergone a full reversal in Lebanon, maps the manifestations and implications for the country, and reflects on what power-sharing theory can learn from Lebanon's consociational experience. [ABSTRACT FROM AUTHOR]

Rather than attending to the social harms underpinning youth offending, justice responses tend to amplify and entrench them. While perhaps less noticeable, inequalities further reside in the systematic disparities in criminalized young adults' opportunities to influence policy and practice and to have control of the choices concerning their present and their future. Resultantly, perhaps, there is a significant disconnect between policy and practice directed towards this group, their lived realities and developmentally specific needs. This article reports on a design-led, participatory study involving 12 criminalized young adults, aged 18–25, oriented to listening to, and learning from, their experiences and visions of social justice in order to influence more socially just responses to offending than we have at present. [ABSTRACT FROM AUTHOR]

Background: Residence in rural areas is often a barrier to health care access. To date, differences in access to kidney transplantation among children who reside in rural and micropolitan areas of the US have not been explored. Methods: A retrospective cohort study of children < 18 years who developed kidney failure between 2000 and 2019 according to the United States Renal Data System (USRDS). We examined the association between rurality of patient residence and time to living and/or deceased donor kidney transplantation (primary outcomes) and waitlist registration (secondary outcome) using Fine–Gray models. Results: We included 18,530 children, of whom 14,175 (76.5%) received a kidney transplant (39.8% from a living and 60.2% from a deceased donor). Residence in micropolitan (subhazard ratio (SHR) 1.16; 95% CI 1.06–1.27) and rural (SHR 1.18; 95% CI 1.06–1.3) areas was associated with better access to living donor transplantation compared with residence in metropolitan areas. There was no statistically significant association between residence in micropolitan (SHR, 0.95; 95%CI 0.88–1.03) and rural (SHR, 0.94; 95%CI 0.86–1.03) areas compared with metropolitan areas in the access of children to deceased donor transplantation. There was also no difference in the time to waitlist registration comparing micropolitan (SHR 1.04; 95%CI 0.98–1.10) and rural (SHR 1.05; 95% CI 0.98–1.13) versus metropolitan areas. Conclusions: In children with kidney failure, residence in rural and micropolitan areas was associated with better access to living donor transplantation and similar access to deceased donor transplantation compared with residence in metropolitan areas. [ABSTRACT FROM AUTHOR]

Research on precarity in higher education has focused on how academics themselves experience this, but less is known about how staff precarity affects teaching and learning. This extended literature review explores how precarious working conditions affect practices aimed at supporting students' writing, such as teaching discipline-specific writing, providing feedback on drafts, and giving guidance about plagiarism and the use of AI. The most significant factors in academic malpractice relate to the quality of teaching and learning, but little time is spent inducting students into the norms of disciplinary knowledge creation, and this is exacerbated by precarious working conditions for subject lecturers. Teaching academic writing often falls to sessional tutors, who lack time or disciplinary knowledge to deal with malpractice. These manifestations of precarity, affecting both casualised subject lecturers and academic support tutors, likely mean fewer opportunities for students to develop their writing skills and engage with knowledge in meaningful ways. [ABSTRACT FROM AUTHOR]

Landlocking of diadromous fish in freshwater systems can have significant genomic consequences. For instance, the loss of the migratory life stage can dramatically reduce gene flow across populations, leading to increased genetic structuring and stronger effects of local adaptation. These genomic consequences have been well‐studied in some mainland systems, but the evolutionary impacts of landlocking in island ecosystems are largely unknown. In this study, we used a genotyping‐by‐sequencing (GBS) approach to examine the evolutionary history of landlocking in common smelt (Retropinna retropinna) on Chatham Island, a small isolated oceanic island 800 kilometres east of mainland New Zealand. We examined the relationship between Chatham Island and mainland smelt and used coalescent analyses to test the number and timing of landlocking events on Chatham Island. Our genomic analysis, based on 21,135 SNPs across 169 individuals, revealed that the Chatham Island smelt was genomically distinct from the mainland New Zealand fish, consistent with a single ancestral colonisation event of Chatham Island in the Pleistocene. Significant genetic structure was also evident within the Chatham Island smelt, with a diadromous Chatham Island smelt group, along with three geographically structured landlocked groups. Coalescent demographic analysis supported three independent landlocking events, with this loss of diadromy significantly pre‐dating human colonisation. Our results illustrate how landlocking of diadromous fish can occur repeatedly across a narrow spatial scale, and highlight a unique system to study the genomic basis of repeated adaptation. [ABSTRACT FROM AUTHOR]

We present a design for a cylindrical cavity resonator with a resonant frequency (TM010 ${\text{TM}}_{010}$ mode) that can be tuned by increasing the separation between the cavity's main body and a discrete lid. This is made possible by incorporating a soft impedance surface into the lid. Tuning between 5 and 6 GHz is achieved by increasing the lid‐to‐cavity separation from 0 to 1.5 mm. We will also discuss the field distribution within the cavity, and use it to explain how the cavity works, and limitations on the performance. [ABSTRACT FROM AUTHOR]

Background: Recent studies demonstrate high offer decline and organ non‐utilization rates are associated with increased pediatric heart transplant waitlist mortality. We sought to determine which donor, candidate, and offer specific variables most importantly influenced these decisions using only data available at the time of each offer. Methods: Retrospective review of pediatric (<18 years) heart donor offers made to pediatric candidates in the United States between 2010 and 2020. In addition to standard donor, candidate, and offer data available in UNOS, we extracted objective and qualitative valvar and myocardial function data from all available donor echocardiogram reports. Results: During the study period, 5625 pediatric donor hearts produced 30 156 offers to 4905 unique candidates, of which 88.7% of all offers were declined and 39.2% of organs were not utilized by pediatric waitlisted candidates. Of the 60.8% utilized hearts, 89.7% had a 'cumulatively' normal echocardiogram at the time of offer acceptance; 62.9% of hearts not utilized for a pediatric candidate also had a cumulatively normal final echocardiogram. Random forest and logistic regression modeling demonstrated good predictive performance (AUROC ≥0.83) of likelihood to accept when utilizing donor, candidate, and offer specific variables. SHAP variable importance scores demonstrated number of prior offer declines and candidate institution's prior year acceptance rates as the two most important variables influencing offer decisions. Conclusions: Behavioral economics appear to play a significant role in pediatric heart transplant candidate institutions' acceptance practices, even when considering the arguably healthier pediatric donor population. Removal of prior institution's decisions from DonorNet may help increase donor utilization. [ABSTRACT FROM AUTHOR]

Cooling electronic devices to cryogenic temperatures (< 77 K) is crucial in various scientific and engineering domains. Efficient cooling involves the removal of heat generated from these devices through thermal contact with either a liquid cryogen or a dry cryostat cold stage. However, as these devices cool, thermal boundary resistance, also known as Kapitza resistance, hinders the heat flow across thermal interfaces, resulting in elevated device temperatures. In transistors, the presence of passivation layers like silicon nitride (SiN) introduces additional interfaces that further impede heat dissipation. This paper investigates the impact of passivation layer thickness on Kapitza resistance at the interface between a solid device and liquid nitrogen. The Kapitza resistance is measured using a capacitance thermometer that has been passivated with SiN layers ranging from 0 to 240 nm. We observe that Kapitza resistance increases with increasing passivation thickness. [ABSTRACT FROM AUTHOR]

The Alpha Centauri system has two close stars Alpha and Beta (A & B) and one much further away: Proxima Centauri. All three stars are co-moving with similar chemistry, which implies they are bound, but the fast orbit of Proxima implies it is gravitationally unbound given the visible mass of A and B. This problem cannot be fixed with the addition of dark matter, which must be uniform on such scales, or adding mass to A and B (their mass is well constrained) or by Modified Newtonian Dynamics. A new model for inertia called Quantized Inertia (QI) has been proposed that solves the galaxy rotation problem by reducing the inertia of low-acceleration stars at the galaxies' edge in a new way, thus keeping them bound without the need for dark matter. It is shown here that if QI is applied to Proxima Centauri in the same way, it predicts the observed orbital velocity, within the bounds of observational uncertainty, and binds Proxima, without the need for extra mass. [ABSTRACT FROM AUTHOR]

Physical Therapists affiliated with Intrepid Spirit Centers evaluate and treat Active Duty Service Members (ADSM) who have duty-limiting post-concussion symptoms to improve the ability to perform challenging tasks associated with military service. The Complex Assessment of Military Performance (CAMP) is a test battery that more closely approximates the occupational demands of ADSM without specific adherence to a particular branch of service or military occupational specialty. Subtasks were developed with military collaborators to include high level skills that all service members must be able to perform such as reacting quickly, maintaining visual stability while moving and changing positions, and scanning for, noting, and/or remembering operationally relevant information under conditions of physical exertion. Objective: The purpose of this observational longitudinal study is to: 1- establish typical performance parameters for ADSM on the CAMP test battery 2- determine the element of the CAMP battery that demonstrate the greatest differences from standard performance and serve as predictors for successful return to duty and 3- develop clinician-facing feedback algorithms and displays and 4—develop materials for clinical dissemination. This ongoing multi-site study is currently funded through the CDMRP and has been approved by the Naval Medical Center Portsmouth IRB. Methods: ADSM undergoing post-concussion rehabilitation at the Intrepid Spirit Centers will be tested within one week of their initial Physical Therapy evaluation and after completing Physical Therapy. Control participants will include males, females, and ADSM from the Special Operations community. Participants will complete an intake form that includes questions about demographics, military service, deployment and concussion history, and profile and duty status. Other measures include those that explore concussion symptoms, sleep quality, post-traumatic stress, and perceptions of resilience. The CAMP includes three separate 10–15 minute tasks. Movement is recorded by wearable inertial sensors and heart rate variability is recorded with a POLAR10 monitor. The "Run-Roll" task requires rapid position changes, combat rolls and quick running forwards and backwards while carrying a simulated weapon. Visual stability before and after the task is also performed. The "Dual-Task Agility" task includes rapid running with and without a weighted vest and a working memory task. The "Patrol Exertion" task requires repeated stepping onto an exercise step while watching a virtual patrol video. Additional tasks include monitoring direction of travel, observing for signs of enemy presence, and reacting to multiple auditory signals embedded in the video. Discussion: Measures that evaluate relevant skills are vital to support safe return to duty for ADSM who may be exposed to imminent danger as part of training or mission demands. The CAMP is designed to be an ecologically valid and clinically feasible assessment that may be more sensitive to capturing subtle impairments that impact duty performance as test skills are integrated into dual and multi-tasks that reflect occupational demands. Assessment results may serve as a more robust indicator of readiness for full return to duty after concussion. [ABSTRACT FROM AUTHOR]

The scarcity of organs for transplant and significant rates of organ transplantation failure mean it is important to identify factors relating to transplant success and failure. Experiencing psychosis or mania is often seen as a contraindication for transplant, and many transplant teams have been cautious at transplanting people with significant mental health difficulties. In this paper we explore whether there is any evidence to support this attitude towards psychiatric diagnosis and transplantation; consider modifiable risks to transplantation; and ask what is needed to provide equitable care for individuals with experience of psychosis. To place context to our discussion, we present the experience of a person who had a history of psychotic experience and who was assessed for double lung transplant. [ABSTRACT FROM AUTHOR]

The purpose of this research was to explore how service dog partners experience the death of their service dog. Twenty-five partners who had lost a service dog self-selected from those who participated in a larger quantitative study. The quantitative study consisted of an online, anonymous survey targeting service dog handlers who had lost a dog within the last five years. Directed content analysis was used to identify prevalent themes. Results demonstrate that while the death of their service dog was a central life event, their grief was often disenfranchised. Many struggled with both the need to quickly acquire another service dog and the subsequent impact this had on their ability to grieve. Given the unique relationship between service dog and handler, it is important that counselors, service dog organizations and veterinarians are aware of the challenges associated with both loss and replacement and offer appropriate support to their clients. [ABSTRACT FROM AUTHOR]

Young adults (ages 18–39) living with cancer often encounter developmental disruptions placing them at risk for anxiety, depression, social isolation, and a lost sense of meaning. To support their sense of belonging, meaning, and illness adaption, the authors developed Through the Lens: Living Beyond Young Adult Cancer, a virtual 8-week synchronous, meaning-centered photovoice group intervention. The study aimed to investigate the feasibility and acceptability of intervention among young adult survivors. Data collection centered on recruitment, group attendance, retention, and exit interview data evaluating barriers and facilitators to participation, and ease and comfort with photovoice group methods. Data analysis included descriptive statistics and thematic analysis of participants' exit interviews. Findings present descriptive results and quotes of the survivors' (n = 11) experiences who participated in two 8-week series of the intervention. Group members found the intervention feasible and acceptable and shared practical strategies to enhance the intervention. [ABSTRACT FROM AUTHOR]

In this afterword to the special issue on Consociationalism and the State: Lebanon and Iraq in Comparative Perspective, we reflect on the insights from the articles in the special issue and their contributions to the wider field of consociationalism studies, including the relationship between the state, state formation, and consociationalism; the interplay between consociationalism and identity construction and change; and the functionality, longevity, and agility of the consociational state. We suggest that the emergent research agenda on consociationalism and the state should engage further with ideas of agency and with wider cross-regional comparisons from the global south in order to show how historically contingent developments precondition conflict processes, group grievances, and post-conflict preferences in power-sharing systems. [ABSTRACT FROM AUTHOR]

Background: Acute respiratory infections (ARIs) during pregnancy are associated with poor maternal and fetal outcomes. Methods: Using U.S. Flu Vaccine Effectiveness Network data (2011–2016) from Washington and Michigan, we tested for respiratory viruses among pregnant and non‐pregnant outpatients matched on age, site, and season (n = 191). Results: Among all participants, detection of human coronaviruses and rhinovirus was common. We also observed differences in virus detection by pregnancy status; human coronaviruses and respiratory syncytial virus (RSV) were detected more frequently among pregnant and non‐pregnant participants, respectively. Conclusions: The role of respiratory viruses in maternal ARI morbidity should be further characterized to inform implementation of prevention interventions including maternal vaccines. [ABSTRACT FROM AUTHOR]

Background: Access to care for children with kidney disease is limited in less well-resourced regions of the world and paediatric nephrology (PN) workforce development with good practical skills is critical. Methods: Retrospective review of a PN training program and trainee feedback from 1999 to 2021, based at Red Cross War Memorial Children's Hospital (RCWMCH), University of Cape Town. Results: A regionally appropriate 1–2-year training program enrolled 38 fellows with an initial 100% return rate to their country of origin. Program funding included fellowships from the International Pediatric Nephrology Association (IPNA), International Society of Nephrology (ISN), International Society of Peritoneal Dialysis (ISPD), and the African Paediatric Fellowship Program (APFP). Fellows were trained on both in- and out-patient management of infants and children with kidney disorders. "Hands-on skills" training included examination, diagnosis and management skills, practical insertion of peritoneal dialysis catheters for management of acute kidney injury and kidney biopsies. Of 16 trainees who completed > 1 year of training, 14 (88%) successfully completed subspecialty exams and 9 (56%) completed a master's degree with a research component. PN fellows reported that their training was appropriate and enabled them to make a difference in their respective communities. Conclusions: This training program has successfully equipped African physicians with the requisite knowledge and skills to provide PN services in resource-constrained areas for children with kidney disease. The provision of funding from multiple organizations committed to paediatric kidney disease has contributed to the success of the program, along with the fellows' commitment to build PN healthcare capacity in Africa. [ABSTRACT FROM AUTHOR]

Cosmological correlators from inflation are often generated at tree level and hence loop contributions are bounded to be small corrections by perturbativity. Here we discuss a scenario where this is not the case. Recently, it has been shown that for any number of scalar fields of any mass, the parity-odd trispectrum of a massless scalar must vanish in the limit of exact scale invariance due to unitarity and the choice of initial state. By carefully handling UV-divergences, we show that the one-loop contribution is non-vanishing and hence leading. Surprisingly, the one-loop parity-odd trispectrum is simply a rational function of kinematics, which we compute explicitly in a series of models, including single-clock inflation. Although the loop contribution is the leading term in the parity-odd sector, its signal-to-noise ratio is typically bounded from above by that of a corresponding tree-level parity-even trispectrum, unless instrumental noise and systematics for the two observables differ. Furthermore, we identify a series of loop contributions to the wavefunction that cancel exactly when computing correlators, suggesting a more general phenomenon. [ABSTRACT FROM AUTHOR]

The practice of teacher noticing students' mathematical thinking often includes three interrelated components: attending to students' strategies, interpreting students' understandings, and deciding how to respond on the basis of students' understanding. This practice gains complexity in technology‐mediated environments (i.e., using technology‐enhanced math tasks) because it requires attending to and interpreting students' engagement with technology. Current frameworks implicitly assume the practice includes noticing the ways students use tools (including technology tools) in their work, but do not explicitly highlight the role of the tool. While research has shown that using these frameworks supports preservice secondary mathematics teachers (PSTs) developing noticing practices, it has also shown that PSTs largely overlook students' technology engagement when they are working on technology‐enhanced tasks (Journal for Research in Mathematics Education, 2010; 41(2):169–202). In this article, we describe our adaptation of Jacobs et al.'s framework for teacher noticing student mathematical thinking to include a focus on making students' technology‐tool engagement explicit when noticing in technology‐mediated environments, the Noticing in Technology‐Mediated Environments (NITE) framework. We describe the theoretical foundations of the framework, provide a video case example, and then illustrate how the framework can be used by mathematics teacher educators to support PSTs' noticing when students are working in technology‐mediated environments. [ABSTRACT FROM AUTHOR]

Objective The Portable Warrior Test of Tactical Agility (POWAR-TOTAL) is a performance-based test designed to assess active-duty service members diagnosed with mild traumatic brain injuries (mTBIs) and could potentially inform return to duty decisions. To examine the validity and responsiveness of the POWAR-TOTAL measure, this study collected self-reported and performance measures by active-duty service members before and after an episode of physical therapist care. Methods Seventy-four individuals, enrolled in care for mTBI symptoms at 1 of 2 concussion specialty Intrepid Spirit Centers, were examined the week that they initiated physical therapy with the intention to return to active duty. Self-reported measures of concussion symptoms, pain, posttraumatic stress, headache, dizziness, and sleep quality were used, as were concurrent measures of mobility and balance. The POWAR-TOTAL task (motor and cognitive skills in single and dual-task conditions) was administered. Forty-nine active-duty service members returned for posttherapy testing using the same test battery. Effect sizes for change in measures were calculated. Construct validity was assessed by correlating change scores on POWAR with concurrent self-report and mobility measures. Responsiveness was evaluated using an anchor-based approach. Results Significant improvements in self-reported and performance-based measures, including POWAR, were observed after therapy with moderate to large effect sizes. Improvement in POWAR performance correlated with improvement in both performance and self-reported measures. After therapy, individuals who registered improvement on the Patient Global Impression of Change scale demonstrated significantly faster POWAR motor performance than those who rated little or no improvement in their condition. Conclusion The POWAR-TOTAL captured improvement on a military-specific task after completing physical therapy for mTBI and could serve as an indicator of physical recovery and readiness for return to duty. Impact Challenging cognitive and motor measures for service members may aid in the assessment of recovery and the ability to successfully return to duty after concussion as part of a comprehensive examination approach. [ABSTRACT FROM AUTHOR]

The last few years have seen a mental health crisis for children and young people in the UK, with more young people presenting to services at crisis point. Young people have reported that there is a general lack of support before reaching the point of crisis and police forces in the UK have seen a rise in callouts related to youth mental health problems. We provide an overview of the evidence for joint responses from police and mental health services and highlight the importance of including people with lived experience in the development of crisis services. Most of the available data relates to interventions for adults, with very few studies including children and young people. We outline a new study in the UK aiming to evaluate a joint response for young people experiencing a mental health crisis. Whilst resources for children and young people's crisis services remain limited, joint response models with police forces can help to provide much needed intervention. [ABSTRACT FROM AUTHOR]

The article discusses a research paper on the surgical management of knee joint. Topics mentioned include the main factors that need to be considered in knee joint preservation, the key reasons for the failure of reconstructing an anterior cruciate ligament (ACL), and the effect of an increased or a decreased posterior tibial slope on ACL reconstruction.

Background: Research suggests pets foster affection, connection, and physical activity, yet has failed to address the challenges people diagnosed with cancer face in caring for their pets. The objective of this study was to better understand how pets serve as emotional buffers and/or stressors for people diagnosed with breast cancer, and how their ability to meet their pet's needs affects their well-being. Methods: A cross-section study of people diagnosed with breast cancer in the United States was conducted. Adults diagnosed with stages 0 (in situ) -IV breast cancer and currently the primary guardian of at least one dog or cat and owned the animal(s) for at least 6 months, were recruited for the study. A total of 211 responses, obtained between July – November 2022 were analyzed. The survey included questions about participants' demographics; attachment to their pets; physical, emotional, and functional well-being; social support received from their pet; and 'pet parenting' concerns. Descriptive statistics were calculated to describe participants' demographics. Multiple regression analyses were conducted to determine predictors of pet attachment, well-being, support from pet, and 'pet parenting' concerns. Results: People diagnosed with breast cancer derive substantial support from their pets (80% feel their pet makes them feel loved, needed, and offers a positive presence in the home), yet only 50% of participants feel this relationship is supported by their medical team. Controlling for owner demographics, heightened levels of pet-related guilt and concerns, along with lower perceived support from their pet, are all significant predictors of a lower quality of life. Conclusions: Findings highlight the benefits pets offer people diagnosed with breast cancer, yet also the distress they feel in trying to meet their pet's needs. Assessment conversations about pet ownership, including pet-related support systems, are needed to validate people's concerns and support the identification and development of pet support teams. Medical team facilitated discussions about pet care needs is suggested to demonstrate support for the pet-parent bond and help normalize feelings of guilt related to challenges in meeting their pet's needs. These discussions could be aided through the development of research-driven intervention strategies and online, freely accessible targeted tools. [ABSTRACT FROM AUTHOR]

Purpose: Neurothrombectomy catheters can disrupt or injure the vessel wall. This potential injury is often studied in animal or cadaver models, but prior work suggests that endothelialized silicone models may be an option for early in vitro assessment. The purpose of this work was to create a complex, clinically-relevant endothelialized neurovascular silicone model, and to determine the utility of the model for evaluating vessel injury due to catheter simulated use. Methods: Models of the ICA and MCA were fabricated out of silicone, sterilized, coated with fibronectin, placed in bioreactors, and endothelialized with HUVECs. These silicone vessels were maintained under flow for 3 and 7 days, and cellular linings were assessed. Subsequently, 24 silicone vessels were created and treated with neurovascular catheters. Vessels were accessed with a guidewire, microcatheter, and/or aspiration catheter, either once (1-pass) or three times (3-pass). Vessels were then fixed, and injury was evaluated through quantitative image analysis and a visual scoring system. Results: Complex silicone models were successfully endothelialized and maintained with consistent cell linings. The transparent silicone permitted catheter simulated use without fluoroscopy, and injury to the vessel wall was observed and successfully imaged and characterized. Vessels subjected to 3-passes exhibited more injury than 1-pass, and injury increased with the number and size of devices. These results illustrated expected trends and support use of these models for early assessment of vessel injury. Conclusion: Complex silicone neurovascular models can be endothelialized and used in vitro to assess and compare injury due to the use of neurovascular catheters. [ABSTRACT FROM AUTHOR]

The evolution of Batesian mimicry – whereby harmless species avoid predation through their resemblance to harmful species – has long intrigued biologists. In rare cases, Batesian mimicry is linked to intraspecific colour variation, in which only some individuals within a population resemble a noxious 'model'. Here, we assess intraspecific colour variation within a widespread New Zealand stonefly, wherein highly melanized individuals of Zelandoperla closely resemble a chemically defended aposematic stonefly, Austroperla cyrene. We assess convergence in the colour pattern of these two species, compare their relative palatability to predators, and use genome‐wide association mapping to assess the genetic basis of this resemblance. Our analysis reveals that melanized Zelandoperla overlap significantly with Austroperla in colour space but are significantly more palatable to predators, implying that they are indeed Batesian mimics. Analysis of 194,773 genome‐wide SNPs reveals an outlier locus (ebony) strongly differentiating melanic versus non‐melanic Zelandoperla. Genotyping of 338 specimens from a single Zelandoperla population indicates that ebony explains nearly 70% of the observed variance in melanism. As ebony has a well‐documented role in insect melanin biosynthesis, our findings indicate this locus has a conserved function across deeply divergent hexapod lineages. Distributional records suggest a link between the occurrence of melanic Zelandoperla and the forested ecosystems where the model Austroperla is abundant, suggesting the potential for adaptive shifts in this system underpinned by environmental change. [ABSTRACT FROM AUTHOR]

How do consociations craft their asylum policy, and how do they deal with the rights of "others"? Research has started to explore the relationship between consociational governance and non-ethnic or non-sectarian social groups. Yet, we still know little about how consociations interact with refugee flight on the one hand, and with the ethics of refugee protection on the other. As a form of thick institutional complexity, consociationalism risks limiting the ability of the state to respond to refugee displacement in a manner that is timely, effective, and which respects the rights and dignity of displaced individuals. We draw on Lebanon's response to the arrival of some 1.5 million displaced individuals in the country since the start of Syria's lethal conflict in 2011 as an exploratory case study that seeks to further knowledge on how consociations craft and implement their asylum policy. Specifically, we consider three mechanisms of immobilism that constrain the crafting of unified, responsive, and inclusive asylum policy and that are posed by the consociational state apparatus itself: ethnicization/sectarianization, procrastination, and fragmentation. Building on Lebanon's patterns of refugee policymaking, we show how these mechanisms mutually reinforce one another, backfiring on policy congruence as well as refugee rights and protection. [ABSTRACT FROM AUTHOR]

Background: Communication changes following acquired brain injury (ABI) may necessitate use of augmentative and alternative communication (AAC). Speech pathologists regularly assist people with ABI and their families with AAC assessment and recommendations, as well as education and training on AAC use. To date, there has been no Australian research investigating the perspectives of speech pathologists working in the field of ABI and AAC. This research aimed to 1) Explore speech pathologists' insights regarding enablers and barriers to considerations and uptake, and ongoing use, of AAC by people with ABI and 2) Understand their perspectives on AAC acceptance, abandonment and rejection. Method: A qualitative research design, with semi-structured interviews, was used with seven speech pathologists working across three Australian states. Interviews were transcribed verbatim, and thematically analysed. To triangulate results, the lived experience reflections of one co-author, who has an ABI and uses AAC, were drawn on. Results: Seven themes were identified, relating to four of the five domains of the World Health Organization's assistive technology model. These included that AAC should be person-centred, with consideration of both products and personnel required, and with effective policy aiding AAC trial, uptake and use. Conclusion: This research has highlighted considerations for AAC use by people with ABI, from the perspective of speech pathologists and aided by lived experience reflections. Speech pathologists need to understand the breadth of products, and good practice service steps, to ensure successful AAC use and skill development. Listening to the perspectives of people with ABI is central to that understanding. [ABSTRACT FROM AUTHOR]

Angle‐resolved X‐ray photoelectron spectroscopy (ARXPS) is a technique used for depth‐dependent analysis in the near‐surface region of samples. Calculation of a concentration depth profile using ARXPS requires an inverse Laplace transform, which adds considerable complexity to the analysis. In this insight note, the Tikhonov regularization algorithm for depth profile reconstruction from ARXPS data is examined. The steps required to produce a concentration depth profile are provided. The discussion includes strategies that deal with elastic scattering, electron attenuation, choice of regularization terms and optimization of the regularization parameters. The method is implemented in a Microsoft Excel spreadsheet that allows users to calculate a depth profile for data collected at up to five angles for five different peak components. [ABSTRACT FROM AUTHOR]

Abstract Objectives Methods Results Conclusions Surgical fusion through posterior instrumentation and pedicle screw placement is a long established method for stabilising traumatic spinal fractures. Post-surgical complications include infection and metal work failure, the most common aetiology of which is pedicle screw fracture. Metal work failure rates vary from 15% to 60%. Research relating to factors which predict metal work failure in post-traumatic thoracolumbar spinal fixation is lacking. This study aimed to identify potential risk factors for metalwork failure in patients who had posterior fixation for traumatic thoracolumbar spine fractures.This retrospective cohort analysis was conducted by interrogating the hospital database for neurosurgical post-traumatic thoracolumbar fixation cases between 2015 and 2018 with at least 2 years follow up. Data was collected through electronic medical notes and PACS. Nineteen different patient factors (gender, age, mechanism of injury, presence of concomitant injury spinal or extra-spinal injury, pedicle cross-sectional area, pedicle cancellous bone density, pedicle total bone density, vertebral body bone density, erector spinae muscle density and lumbar spine subcutaneous fat thickness, Charlson comorbidity index, fracture location, surgical approach, long/short segment fixation, whether decompression was done, whether the index level was fixed, and presence of wound infection) were compared.We identified 92 patients with 97 operations, and 9 cases of metal work failure. Two factors were statistically significantly associated with metal work failure: Post-operative wound infection (p = 0.029) and lumbar spine fat thickness (p = 0.024). The relative risk calculated in patients with a wound infection was 3.76. Lumbar spine fat thickness was on average 11.9 mm greater than patients not experiencing metal work failure.This study has identified two factors associated with increased rates of metal work failure: Post-operative wound infection and lumbar spine fat thickness. When assessing surgical candidates these factors may be incorporated into surgical planning. [ABSTRACT FROM AUTHOR]