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Criteria-based Content Analysis (CBCA) has been primarily employed to assess the credibility of child sexual abuse (CSA) allegations. However, several studies on the validity of CBCA have focused on autobiographical events other than CSA. Because of the differences between real cases and the laboratory, we focused specifically on CBCA field studies on both CSA and other areas of application. We formally assessed several ground-truth criteria (and other methodological aspects) in a pool of 36 field studies. Seven archival studies (six of which were on CSA) and seven quasi-experiments (none of which was on CSA) were found to be either methodologically sound (12 studies) or acceptable with reservations (two studies), and were therefore included. We describe the paradigm and methods used in each study. Across studies, most CBCA criteria significantly differed between truthful and deceptive accounts, with similar medium to large effect sizes for the methodologically sound quasi-experiments and archival CSA studies. Our review shows that CBCA criteria may discriminate in domains other than CSA. The implications for the real-world usage of CBCA are discussed. [ABSTRACT FROM AUTHOR]

Despite the large impact chronic obstructive pulmonary disease (COPD) that has on the population, the implementation of new technologies for diagnosis and treatment remains limited. Current practices in ambulatory oxygen therapy used in COPD rely on fixed doses overlooking the diverse activities which patients engage in. To address this challenge, we propose a software architecture aimed at delivering patient-personalized edge-based artificial intelligence (AI)-assisted models that are built upon data collected from patients' previous experiences along with an evaluation function. The main objectives reside in proactively administering precise oxygen dosages in real time to the patient (the edge), leveraging individual patient data, previous experiences, and actual activity levels, thereby representing a substantial advancement over conventional oxygen dosing. Through a pilot test using vital sign data from a cohort of five patients, the limitations of a one-size-fits-all approach are demonstrated, thus highlighting the need for personalized treatment strategies. This study underscores the importance of adopting advanced technological approaches for ambulatory oxygen therapy. [ABSTRACT FROM AUTHOR]

Background and Aims: The prevalence of chronic non-communicable diseases, particularly metabolic syndrome (MetS), has increased among the prison population. Nevertheless, we have limited data on metabolic dysfunction-associated steatotic liver disease (MASLD), the hepatic manifestation of this syndrome. We aimed to investigate the prevalence and risk factors of MASLD and MASLD-associated liver fibrosis in the penitentiary population in Catalonia, Spain. Method: A cross-sectional observational study involving eight penitentiary centers. Participants had at least one metabolic disorder and were at a closed-regimen penitentiary. Individuals with concomitant liver diseases and/or alcohol risk consumption were excluded. Significant fibrosis and MASLD were defined as liver stiffness ≥8 kPa and a controlled attenuation parameter ≥275 dB/m by vibration-controlled transient elastography (VCTE), respectively. After exclusions, metabolic inmates with VCTE were analyzed. Logistic regression analysis was performed to identify predictors of MASLD and MASLD-associated significant fibrosis. Results: Out of the 4338 inmates studied, 1290 (29.7%) had metabolic disorders, and 646 (14.9%) underwent VCTE. The mean age was 48.0 years (SD 12.1), and 89.5% were male. MASLD prevalence was 33.9%. Significant fibrosis and MASLD-associated significant fibrosis were found in 16.4% and 9.4% of inmates, respectively. In the multivariate analysis, T2D, waist circumference, MetS, and higher ALT values were identified as independent risk factors for MASLD and MASLD-associated significant fibrosis amongst the prison population. Conclusions: Metabolic disorders including MASLD are highly prevalent among inmates. The prevalence of significant fibrosis seems notably higher than that of the general population, underscoring the need for targeted screening programs and therapeutic interventions in the incarcerated population. [ABSTRACT FROM AUTHOR]

The verifiability of a suspect's alibi is often interpreted as a sign of innocence. Because the police resources are limited, verifiability could be used to dismiss suspects of minor offenses. We examined whether alibi verifiability actually indicates innocence for minor crimes. In Experiment 1, participants imagined they were guilty or innocent suspects of minor crimes and selected a response to convince the police of their innocence. Compared to innocent suspects, guilty suspects were more likely to select pseudo‐verifiable responses (which seemed verifiable but were not) rather than non‐verifiable responses. Experiment 2 revealed that pseudo‐verifiable responses increased observers' perceptions of innocence (rather than guilt). Experiment 3 suggested that people infer the police will not verify alibis of minor crimes, which may lead people to invent pseudo‐verifiable responses. These results indicate that apparent verifiability does not necessarily indicate innocence. The police should systematically test alternative hypotheses whenever they encounter apparent verifiable responses. [ABSTRACT FROM AUTHOR]

Unavoidable stress can lead to perceived lack of control and learned helplessness, a risk factor for depression. Avoiding punishment and gaining rewards involve updating the values of actions based on experience. Such updating is however useful only if action values are sufficiently stable, something that a lack of control may impair. We examined whether self-reported stress uncontrollability during the first wave of the COVID-19 pandemic predicted impaired reward-learning. In a preregistered study during the first-wave of the COVID-19 pandemic, we used self-reported measures of depression, anxiety, uncontrollable stress, and COVID-19 risk from 427 online participants to predict performance in a three-armed-bandit probabilistic reward learning task. As hypothesised, uncontrollable stress predicted impaired learning, and a greater proportion of probabilistic errors following negative feedback for correct choices, an effect mediated by state anxiety. A parameter from the best-fitting hidden Markov model that estimates expected beliefs that the identity of the optimal choice will shift across images, mediated effects of state anxiety on probabilistic errors and learning deficits. Our findings show that following uncontrollable stress, anxiety promotes an overly volatile representation of the reward-structure of uncertain environments, impairing reward attainment, which is a potential path to anhedonia in depression. [ABSTRACT FROM AUTHOR]

Background: In this systematic review and meta-analysis, we examined the evidence on transjugular intrahepatic portosystemic shunt (TIPS) as a bridge to elective and emergency surgery in cirrhotic patients. We aimed to assess the perioperative characteristics, management approaches, and outcomes of this intervention, which is used to achieve portal decompression and enable the safe performance of elective and emergent surgery. Methods: MEDLINE and Scopus were searched for studies reporting the outcomes of cirrhotic patients undergoing elective and emergency surgery with preoperative TIPS. The risk of bias was evaluated using the methodological index for non-randomized studies of interventions, and the JBI critical appraisal tool for case reports. The outcomes of interest were: 1. Surgery after TIPS; 2. Mortality; 3. Perioperative transfusions; and 4. Postoperative liver-related events. A DerSimonian and Laird (random-effects) model was used to perform the meta-analyses in which the overall (combined) effect estimate was presented in the form of an odds ratio (summary statistic). Results: Of 426 patients (from 27 articles), 256 (60.1%) underwent preoperative TIPS. Random effects MA showed significantly lower odds of postoperative ascites with preoperative TIPS (OR = 0.40, 95% CI 0.22–0.72; I2 = 0%). There were no significant differences in 90-day mortality (3 studies: OR = 0.76, 95% CI 0.33–1.77; I2 = 18.2%), perioperative transfusion requirement (3 studies: OR = 0.89, 95% CI 0.28–2,84; I2 = 70.1%), postoperative hepatic encephalopathy (2 studies: OR = 0.97, 95% CI 0.35–2.69; I2 = 0%), and postoperative ACLF (3 studies: OR = 1.02, 95% CI 0.15–6.8, I2 = 78.9%). Conclusions: Preoperative TIPS appears safe in cirrhotic patients who undergo elective and emergency surgery and may have a potential role in postoperative ascites control. Future randomized clinical trials should test these preliminary results. [ABSTRACT FROM AUTHOR]

Abiotic environmental conditions can significantly influence the way species interact. In particular, plant–herbivore interactions can be substantially dependent on temperature and nutrients. The overall product of these relationships is critical for the fate and stability of vegetated ecosystems like marine forests. The last few decades have seen a rapid spread of barrens on temperate rocky reefs mainly as a result of overgrazing. The ecological feedbacks that characterize the barren state involve a different set of interactions than those occurring in vegetated habitats. Reversing these trends requires a proper understanding of the novel feedbacks and the conditions under which they operate. Here, we explored the role of a secondary herbivore in reinforcing the stability of barrens formed by sea urchin overgrazing under different nutrient conditions. Combining comparative and experimental studies in two Mediterranean regions characterized by contrasting nutrient conditions, we assessed: (i) if the creation of barren areas enhances limpet abundance, (ii) the size‐specific grazing impact by limpets, and (iii) the ability of limpets alone to maintain barrens. Our results show that urchin overgrazing enhanced limpet abundance. The effects of limpet grazing varied with nutrient conditions, being up to five times more intense under oligotrophic conditions. Limpets were able to maintain barrens in the absence of sea urchins only under low‐nutrient conditions, enhancing the stability of the depauperate state. Overall, our study suggests a greater vulnerability of subtidal forests in oligotrophic regions of the Mediterranean and demonstrates the importance of environment conditions in regulating feedbacks mediated by plant–herbivore interactions. [ABSTRACT FROM AUTHOR]

Dyslipidemia in gestational diabetes has been associated with worse perinatal outcomes. The ANGPTL3-4-8 axis regulates lipid metabolism, especially in the transition from fasting to feeding. In this study, we evaluated the response of ANGPTL3, 4, and 8 after the intake of a mixed meal in women with normal glucose tolerance and gestational diabetes, and we assessed their gene expressions in different placental locations. Regarding the circulating levels of ANGPTL3, 4, and 8, we observed an absence of ANGPTL4 response after the intake of the meal in the GDM group compared to its presence in the control group. At the placental level, we observed a glucose tolerance-dependent expression pattern of ANGPTL3 between the two placental sides. When we compared the GDM pregnancies with the control pregnancies, a downregulation of the maternal side ANGPTL3 expression was observed. This suggests a dysregulation of the ANGPTL3-4-8 axis in GDM, both at the circulating level after ingestion and at the level of placental expression. Furthermore, we discerned that the expressions of ANGPTL3, 4, and 8 were related to birth weight and placental weight in the GDM group, but not in the control group, which suggests that they may play a role in regulating the transplacental passage of nutrients. [ABSTRACT FROM AUTHOR]

Energy homeostasis and metabolism in mammals are strongly influenced by seasonal changes. Variations in photoperiod patterns drive adaptations in body weight and adiposity, reflecting changes in the regulation of food intake and energy expenditure. Humans also show distinct patterns of energy balance depending on the season, being more susceptible to gaining weight during a specific time of the year. Changes in body weight are mainly reflected by the adipose tissue, which is a key metabolic tissue and is highly affected by circannual rhythms. Mostly, in summer-like (long-active) photoperiod, adipocytes adopt a rather anabolic profile, more predisposed to store energy, while food intake increases and energy expenditure is reduced. These metabolic adaptations involve molecular modifications, some of which have been studied during the last years and are summarized in this review. In addition, there is a bidirectional relation between obesity and the seasonal responses, with obesity disrupting some of the seasonal responses observed in healthy mammals, and altered seasonality being highly associated with increased risk of developing obesity. This suggests that changes in photoperiod produce important metabolic alterations in healthy organisms. Biological rhythms impact the regulation of metabolism to different extents, some of which are already known, but further research is needed to fully understand the relationship between energy balance and seasonality. [ABSTRACT FROM AUTHOR]

Over the past decades, the psychological science has accumulated a large corpus of empirical knowledge about police interviews, deception detection, and suspects' confessions. However, it is unclear whether European police forces' practices and beliefs are consistent with recommendations derived from this empirical literature. The study described in this report is part of a larger research project examining European police investigators' practices and beliefs. An online survey was administered to Guardia Civil (n = 89) and Policía Nacional investigators (n = 126). The survey inquired about the length, frequency and electronic recording of interviews, the suspects' use of their right to remain silent, investigators' self-reported skills in distinguishing between truthful and deceptive statements, their estimates of the frequency of (false) confessions, and their use of specific interview tactics. The outcomes provide insights into investigators' knowledge and practices, highlight specific needs, and allow for a comparison between European and North American police forces. [ABSTRACT FROM AUTHOR]

Future data-intensive intelligent applications are required to traverse across the cloud-to-edge-to-IoT continuum, where cloud and edge resources elegantly coordinate, alongside sensor networks and data. However, current technical solutions can only partially handle the data outburst associated with the IoT proliferation experienced in recent years, mainly due to their hierarchical architectures. In this context, this paper presents a reference architecture of a meta-operating system (RAMOS), targeted to enable a dynamic, distributed and trusted continuum which will be capable of facilitating the next-generation smart applications at the edge. RAMOS is domain-agnostic, capable of supporting heterogeneous devices in various network environments. Furthermore, the proposed architecture possesses the ability to place the data at the origin in a secure and trusted manner. Based on a layered structure, the building blocks of RAMOS are thoroughly described, and the interconnection and coordination between them is fully presented. Furthermore, illustration of how the proposed reference architecture and its characteristics could fit in potential key industrial and societal applications, which in the future will require more power at the edge, is provided in five practical scenarios, focusing on the distributed intelligence and privacy preservation principles promoted by RAMOS, as well as the concept of environmental footprint minimization. Finally, the business potential of an open edge ecosystem and the societal impacts of climate net neutrality are also illustrated. [ABSTRACT FROM AUTHOR]

This article presents a description and analysis of the practices and representations around the ethno-educational processes of Wayuu students in basic, middle and higher education centres in La Guajira and Santander (Colombia). Based on our ethnographic experience in the field, we reflect on the role that the ethno-educational policies of the Colombian state play in shaping the dispositions toward schooling of young Wayuu students, their job expectations, as well as the ruptures and continuities with the cultural practices within their families and Wayuu communities of origin. In our analysis we explore three different areas of experience (Wayuu culture, education and employment), which we interpret from the perspective of the different agents involved: students, teachers, families and Wayuu communities. Based on our results, we can conclude that, in the context of these ethno-educational policies, continued schooling in these centres decisively transforms students' worldviews, their self-understanding schemes and their relationship with their community. Specifically, we think that profound collective and personal changes are taking place in the young Wayuu generations, mainly in terms of the subjectivation of class, race and gender relations, family structures and the conformation of their academic and work expectations. [ABSTRACT FROM AUTHOR]

Nuclear magnetic resonance (NMR)-based advanced lipoprotein tests have demonstrated that LDL and HDL particle numbers (LDL-P and HDL-P) are more powerful cardiovascular (CV) risk biomarkers than conventional cholesterol markers. Of interest, in people living with HIV (PLHIV), predictors of preclinical atherosclerosis and vascular dysfunction may be associated with impaired immune function. We previously stated that immunological non-responders (INR) were at higher CV risk than immunological responders (IR) before starting antiretroviral therapy (ART). Using Liposcale® tests, we characterized the lipoprotein profile from the same cohort of PLHIV at month 12 and month 36 after starting ART, intending to explore what happened with these indicators of CV risk during viral suppression. ART initiation dissipates the differences in lipoprotein-based CV risk markers between INR and IR, and only an increase in the number of HDL-P was found in INR + IR when compared to controls (p = 0.047). Interestingly, CD4+ T-cell counts negatively correlated with medium HDL-P concentrations at month 12 in all individuals (ρ = −0.335, p = 0.003). Longitudinal analyses showed an important increase in LDL-P and HDL-P at month 36 when compared to baseline values in both IR and INR. A proper balance between a proatherogenic and atherogenic environment may be related to the reconstitution of CD4+ T-cell count in PLHIV. [ABSTRACT FROM AUTHOR]

Over the last few years, new materials have been developed which a priori, appear to improve passive energy efficiency in buildings. This article focuses on chromogenic devices that allow changing their optical properties in a reversible manner through some external stimulus. The covering of the envelopes may have different textures or colors, which determine the amount of solar radiation absorbed by the material compared to the incident radiation. In buildings with a high percentage of roof relative to façade, the surface finish plays an interesting role in the energy demand. In the present work, the influence of the application of thermochromic materials to the roofs of commercial buildings is analyzed. It has been demonstrated that the application of a thermochromic surface finish can produce savings of annual energy demand between 1% and 12% in kilowatt-hours and kilograms of CO2 and they become more significant for construction solutions with higher transmittances values. Then, the impact of applying a thermochromic finish per day is analyzed and which transition temperature range will be the most optimal to the highest energy performance is discussed. At the same time, an assessment is made of the optimal cost; although economic investment is not currently amortized, it is a good resource for reducing energy demand in buildings. [ABSTRACT FROM AUTHOR]

Teaching of digital journalism, or cyberjournalism, in Spanish universities is here to stay. Its long development since the first courses in this discipline were added to college curricula in the mid-1990s until the beginning of the 2020s, when the number of such courses exceeds 100, has led to the consolidation of this specialty. Based on a review of the syllabi of all courses related to cyberjournalism (n = 119) published online by Spanish universities, as well as a survey of their teachers (n = 51), the results of this study depicts the profile of teaching about digital journalism in Spain. The results confirm the relevance and academic strength of this discipline, albeit also revealing the difficulties faced by teachers in keeping their courses up to date in a context of rapid and continuous change in the journalistic profession. [ABSTRACT FROM AUTHOR]

Background: Many genes and molecular pathways are associated with obesity, but the mechanisms from genes to obesity are less well known. Eating behaviors represent a plausible pathway, but because the relationships of eating behaviors and obesity may be bi-directional, it remains challenging to resolve the underlying pathways. A longitudinal approach is needed to assess the contribution of genetic risk during the development of obesity in childhood. In this study we aim to examine the relationships between the polygenic risk score for body mass index (PRS-BMI), parental concern of overeating and obesity indices during childhood. Methods: The IDEFICS/I.Family study is a school-based multicenter pan-European cohort of children observed for 6 years (mean ± SD follow-up 5.8 ± 0.4). Children examined in 2007/2008 (wave 1) (mean ± SD age: 4.4 ± 1.1, range: 2–9 years), in 2009/2010 (wave 2) and in 2013/2014 (wave 3) were included. A total of 5112 children (49% girls) participated at waves 1, 2 and 3. For 2656 children with genome-wide data we constructed a PRS based on 2.1 million single nucleotide polymorphisms. Z-score BMI and z-score waist circumference (WC) were assessed and eating behaviors and relevant confounders were reported by parents via questionnaires. Parental concern of overeating was derived from principal component analyses from an eating behavior questionnaire. Results: In cross-lagged models, the prospective associations between z-score obesity indices and parental concern of overeating were bi-directional. In mediation models, the association between the PRS-BMI and parental concern of overeating at wave 3 was mediated by baseline z-BMI (β = 0.16, 95% CI: 0.10, 0.21) and baseline z-WC (β = 0.17, 95% CI: 0.11, 0.23). To a lesser extent, baseline parental concern of overeating also mediated the association between the PRS-BMI and z-BMI at wave 3 (β = 0.10, 95% CI: 0.07, 0.13) and z-WC at wave 3 (β = 0.09, 95% CI: 0.07, 0.12). Conclusions: The findings suggest that the prospective associations between obesity indices and parental concern of overeating are likely bi-directional, but obesity indices have a stronger association with future parental concern of overeating than vice versa. The findings suggest parental concern of overeating as a possible mediator in the genetic susceptibility to obesity and further highlight that other pathways are also involved. A better understanding of the genetic pathways that lead to childhood obesity can help to prevent weight gain. Trial registration: Registry number: ISRCTN62310987 Retrospectively registered 17 September 2018. [ABSTRACT FROM AUTHOR]

Background: Many genes and molecular pathways are associated with obesity, but the mechanisms from genes to obesity are less well known. Eating behaviors represent a plausible pathway, but because the relationships of eating behaviors and obesity may be bi-directional, it remains challenging to resolve the underlying pathways. A longitudinal approach is needed to assess the contribution of genetic risk during the development of obesity in childhood. In this study we aim to examine the relationships between the polygenic risk score for body mass index (PRS-BMI), parental concern of overeating and obesity indices during childhood. Methods: The IDEFICS/I.Family study is a school-based multicenter pan-European cohort of children observed for 6 years (mean ± SD follow-up 5.8 ± 0.4). Children examined in 2007/2008 (wave 1) (mean ± SD age: 4.4 ± 1.1, range: 2–9 years), in 2009/2010 (wave 2) and in 2013/2014 (wave 3) were included. A total of 5112 children (49% girls) participated at waves 1, 2 and 3. For 2656 children with genome-wide data we constructed a PRS based on 2.1 million single nucleotide polymorphisms. Z-score BMI and z-score waist circumference (WC) were assessed and eating behaviors and relevant confounders were reported by parents via questionnaires. Parental concern of overeating was derived from principal component analyses from an eating behavior questionnaire. Results: In cross-lagged models, the prospective associations between z-score obesity indices and parental concern of overeating were bi-directional. In mediation models, the association between the PRS-BMI and parental concern of overeating at wave 3 was mediated by baseline z-BMI (β = 0.16, 95% CI: 0.10, 0.21) and baseline z-WC (β = 0.17, 95% CI: 0.11, 0.23). To a lesser extent, baseline parental concern of overeating also mediated the association between the PRS-BMI and z-BMI at wave 3 (β = 0.10, 95% CI: 0.07, 0.13) and z-WC at wave 3 (β = 0.09, 95% CI: 0.07, 0.12). Conclusions: The findings suggest that the prospective associations between obesity indices and parental concern of overeating are likely bi-directional, but obesity indices have a stronger association with future parental concern of overeating than vice versa. The findings suggest parental concern of overeating as a possible mediator in the genetic susceptibility to obesity and further highlight that other pathways are also involved. A better understanding of the genetic pathways that lead to childhood obesity can help to prevent weight gain. Trial registration: Registry number: ISRCTN62310987 Retrospectively registered 17 September 2018. [ABSTRACT FROM AUTHOR]

Laboratory-based deception-detection experiments often fail to capture the features of everyday life lie detection among ordinary citizens. In this study, we examined how people [try to] detect deception in real life. Over 10 weeks, every time the participants felt they had detected a lie, they filled in an online survey. Results show that, in everyday life, many lies are detected unexpectedly, often from non-behavioral indicators, that people suspecting deception search for both behavioral cues and non-behavioral information, but that non-behavioral information is more useful to detect deception. The study addresses aspects unexplored in prior studies on everyday life lie detection, provides new insights, and has theoretical implications. [ABSTRACT FROM AUTHOR]

Differential miRNA plasma profiles associated with the spontaneous loss of HIV-1 control: miR-199a-3p and its potential role as a biomarker for quick screening of elite controllers People living with HIV (PLWH) who are able to maintain suppressed viral load (VL) for years in the absence of antiretroviral therapy (ART) are known as elite controllers (ECs). From the 23 miRNAs, 22 miRNAs were positively correlated with viral load (VL), seven miRNAs were positively correlated with CD4 SP + sp T-cell counts, and 11 miRNAs were positively correlated with CD8 SP + sp T-cell counts (Table S3). Then, we also evaluated the plasma miRNA profile in TCs under the postloss condition and we found 38 miRNAs differentially expressed among groups, suggesting that viremia strongly influences the plasma miRNA profile of ECs (Figure 2A, Table S4). [Extracted from the article]

• This study is the first to use follitropin delta as a stimulatory medication in intrauterine insemination. • It provides validation of an original personalized intrauterine insemination dosing regimen based on anti-Müllerian hormone values and weight. • A total of 258 cycles led to 43 clinical pregnancies (16.7%), with six multiple pregnancies. • Only four live twin births were observed, representing 1.6% of the total cycles. What is the efficacy and safety of individualized follitropin delta dosing for ovarian stimulation in intrauterine insemination (IUI)? This single-centre, prospective, open-label, single-cohort study involving 106 patients established an original dosing regimen based on body weight and anti-Müllerian hormone (AMH) concentrations, with adjustments based on the ovarian response from the previous IUI cycle. Each participant was enrolled in a maximum of three IUI cycles. Mean age was 34.5 ± 4.5 years, mean weight 69.2 ± 11.2 kg, mean AMH 15.7 ± 8.6 pmol/l, mean FSH 6.3 ± 2.6 IU/l and mean antral follicle count 16.4 ± 8.2. The percentage of patients who produced more than three mature follicles was 1.9%, 0% and 1.5%, respectively, for the three IUI cycles. The percentage of patients with two or three mature follicles was 34.0%, 36.9% and 47.1% for the three IUI cycles. The clinical pregnancy rate per IUI cycle was 17.9%, 14.3% and 17.6% for the three cycles, with a cumulative clinical pregnancy rate of 40.6%. Out of 258 cycles, 43 (16.7%) resulted in clinical pregnancy, with six of those resulting in multiple pregnancies (14.0%). Two resulted in spontaneous reduction within the first trimester and four resulted in live twin births, representing only 1.6% of the total cycles. This study is the first to utilize follitropin delta for stimulation in IUI. It demonstrates that individualized dosing is both effective and safe, resulting in satisfactory cumulative pregnancy rates and an acceptable multiple pregnancy rate, thus achieving the primary objectives of the research. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the safety profile and the number of usable blastocysts on day 5 and on day 6 after treatment with an individualized dosing regimen of a follitropin delta and highly purified human menopausal gonadotropin (HP-hMG) for controlled ovarian stimulation.Design: Multicenter, open label, exploratory study.Setting: Reproductive medicine clinics.Patient(s): A total of 110 patients (aged 18-40 years).Intervention(s): Follitropin delta coadministered with HP-hMG, with follitropin delta dose fixed according to an established algorithm and HP-hMG dose at 75 IU when the follitropin delta starting dosage was <12 μg; 150 IU when follitropin delta dosage was 12 μg and weight <100 kg, and 225 IU when follitropin delta dosage was 12 μg and weight ≥100 kg (dosage adjustments confined to HP-hMG only).Main Outcome Measure(s): Mean number of good-quality blastocysts obtained at day 5 and day 6 as well as the proportion of women with ovarian hyperstimulation syndrome (OHSS).Result(s): A cohort study was compared with the follitropin delta group from the Evidence-based Stimulation Trial with Human Recombinant Follicle-Stimulating Hormone in Europe and Rest of World 1 (ESTHER-1) study. Even when stratified by age, a statistically significantly higher mean in the number of oocytes retrieved and number of good-quality blastocysts was observed in this study compared with the ESTHER-1 trial in which follitropin delta was used alone. The rate of patients triggered with a gonadotropin-releasing hormone agonist was statistically significantly higher in our Menopur and Rekovelle Combined Study (MARCS) cohort (43%) when compared with the rates reported in the follitropin delta cohort in the ESTHER-1 study (2.3%). Incidence of any grade of OHSS was 9.3% in the present study compared to 2.6% in follitropin delta group from ESTHER-1 trial. No cases of moderate or severe OHSS were observed in our study compared with 1.4% in the follitropin delta group of ESTHER-1.Conclusion(s): Optimizing the ovarian response during in vitro fertilization employing a mixed protocol of individualized dosing of follitropin delta and HP-hMG resulted in a statistically significant number of usable blastocysts on days 5 and 6 with an increased risk of mild OHSS, which did not require medical intervention or hospitalization.Clinical Trial Registration Number: NCT03483545. [ABSTRACT FROM AUTHOR]

Pavlovian associations drive approach towards reward-predictive cues, and avoidance of punishment-predictive cues. These associations "misbehave" when they conflict with correct instrumental behavior. This raises the question of how Pavlovian and instrumental influences on behavior are arbitrated. We test a computational theory according to which Pavlovian influence will be stronger when inferred controllability of outcomes is low. Using a model-based analysis of a Go/NoGo task with human subjects, we show that theta-band oscillatory power in frontal cortex tracks inferred controllability, and that these inferences predict Pavlovian action biases. Functional MRI data revealed an inferior frontal gyrus correlate of action probability and a ventromedial prefrontal correlate of outcome valence, both of which were modulated by inferred controllability. Author summary: Using a combination of computational modeling, neuroimaging (both EEG and fMRI), and behavioral analysis, we present evidence for a dual-process architecture in which Pavlovian and instrumental action values are adaptively combined through a Bayesian arbitration mechanism. Building on prior research, we find neural signatures of this arbitration mechanism in frontal cortex. In particular, we show that trial-by-trial changes in Pavlovian influences on action can be predicted by our computational model, and are reflected in midfrontal theta power, as well as inferior frontal and ventromedial prefrontal cortex fMRI responses. [ABSTRACT FROM AUTHOR]

Purpose: Little research exists on the influence of emotion in forensic settings. To start filling this gap, we used a hypothetical interrogation scenario to examine the effects of emotional state on judgement, decision making, and information‐processing style across two separate experiments. Methods: The participants were induced a specific emotion. Then, they read a scenario where a suspect was arrested and rated (1) the suspect's guilt, and (2) the extent to which they would use a number of tactics to interview the suspect. Based on the feelings‐as‐information theory and cognitive‐appraisal theories of emotion, we predicted that relative to angry or happy participants, sad participants would be less inclined to judge the suspect as guilty (judgement), would show a stronger tendency to select benevolent interrogation tactics and a weaker tendency to select hostile interrogation tactics (decision making), and would be more likely to use an analytic (rather than a heuristic) processing style. Results: In Experiment 1 (conducted with college students), the judgement hypothesis was supported. In Experiment 2 (with mTurkers), the decision‐making hypothesis was supported. A meta‐analysis of the two experiments revealed that participants were more willing to select benevolent than hostile interrogation tactics and that, as predicted, sad participants were more willing than angry or happy participants to select benevolent tactics. However, emotion did not affect the participants' tendency to select hostile tactics. Conclusion: We tested emotion theories in an interrogation scenario. The significant results were consistent with the feelings‐as‐information and cognitive‐appraisal theories of emotion and have practical relevance. [ABSTRACT FROM AUTHOR]

• TcTASV-C, a secreted virulence factor of trypomastigotes, was assayed as a vaccine antigen. • Different immunization schemes employing TcTASV-C along with several adjuvants were assessed. • Vaccination with TcTASV-C and U-Omp19 gave the best protection outcome. • TcTASV-C and U-Omp 19 induced cellular responses, with lymphocytes secreting IFNg and IL-17. • Mice vaccinated with TcTASV-C and U-Omp19 survived after a lethal T. cruzi challenge. The development of a Chagaś disease vaccine has yet the need for the identification of novel combinations of antigens and adjuvants. Here, the performance of TcTASV-C proteins that are virulence factors of trypomastigotes and belong to a novel surface protein family specific for T. cruzi , have been evaluated as antigens for a prophylactic vaccine. Several immunization schemes in which TcTASV-C was combined with aluminum hydroxide, saponin and/or U-Omp19 were assayed. Aluminum hydroxide and saponin were assayed together to trigger different pathways of the immune response simultaneously. U-Omp19 is a promising novel adjuvant able to promote a Th1 immune response with IFNg production, thus an interesting molecule to be tested as adjuvant for the control of T. cruzi infection. Therefore, U-Omp19 was added to the aluminum hydroxide-saponin formulation as well as assayed individually with TcTASV-C. The immunization with TcTASV-C and U-Omp19 had the best performance as a prophylactic vaccine. Mice presented the lowest parasitemias and improved survival by 40% after being challenged with a highly virulent T. cruzi strain, which promoted 100% mortality in all other immunized groups. Immunization with TcTASV-C and U-Omp19 triggered cellular responses with IFN-γ and IL-17 production and with lytic antibodies that could explain the protection achieved by this vaccination scheme. To our knowledge, this is the first time that U-Omp19 is tested with a defined T. cruzi antigen in a vaccine formulation. [ABSTRACT FROM AUTHOR]

The trust that citizens place in the media and whether it is conditioned by their ideological positioning are analyzed. Likewise, how ideology affects the perception of media as creators and disseminators of disinformation is studied. The results from a representative survey of the Spanish population (n = 1,000) reveal polarized media consumption in Spain. Ideology plays an important role in trust in the media, drawing well-differentiated media ecosystems according to ideology, which also affects the perception that citizens have of the media as spreaders of disinformation. [ABSTRACT FROM AUTHOR]

With the advent of fog and edge computing paradigms, computation capabilities have been moved toward the edge of the network to support the requirements of highly demanding services. To ensure that the quality of such services is still met in the event of users' mobility, migrating services across different computing nodes becomes essential. Several studies have emerged recently to address service migration in different edge-centric research areas, including fog computing, multi-access edge computing (MEC), cloudlets, and vehicular clouds. Since existing surveys in this area focus on either VM migration in general or migration in a single research field (e.g., MEC), the objective of this survey is to bring together studies from different, yet related, edge-centric research fields while capturing the different facets they addressed. More specifically, we examine the diversity characterizing the landscape of migration scenarios at the edge, present an objectivedriven taxonomy of the literature, and highlight contributions that rather focused on architectural design and implementation. Finally, we identify a list of gaps and research opportunities based on the observation of the current state of the literature. One such opportunity lies in joining efforts from both networking and computing research communities to facilitate future research in this area. [ABSTRACT FROM AUTHOR]

Background: Research shows that people believe deception can be detected from behavioral cues despite their past experience of detecting lies from non-behavioral, contextual information (evidence, third-person reports, etc.). However, in previous research, the question about beliefs was necessarily general, while the question about revealing information was always about a specific lie. In this study, we addressed this problem. Method: Participants first indicated how they believed lies can be detected (beliefs; Questionnaire 1 or Q1). Next, they described either how they, in their past, detected a specific lie, several lies, or how they, in general, detect lies in their everyday lives (revealing information; Q2). Results: Regardless of the focus of Q2, and in line with prior research, behavioral cues were reported less often, and contextual indicators more often, in responding to Q2 than in responding to Q1. However, contrary to prior findings, behavioral cues still predominated in the responses to Q2. Conclusions: We found no evidence that the specific-vs.-general focus of the questions changed the pattern of results, which apparently depended solely on whether participants reported beliefs or revealing information. We provide explanations for the prevalence of behavioral cues in Q2 responses, and make suggestions for future research. [ABSTRACT FROM AUTHOR]

The Covid-19 pandemic has confined millions of citizens in their homes. The situation of isolation has many consequences at multiple levels: social, psychological, economic, educational..., and also communicative. Based on a survey to 1,122 people during the most severe confinement phase, this article aims to analyze how information consumption has been modified during this period of time, and how citizens assess media coverage of Covid-19. The results show citizenship get more news and more frequently than before the health crisis. All in all, citizens maintain a critical attitude towards media coverage of the outbreak, which is, according to the results, conditioned by the media ideology, and reported in a sensationalist way, generating unnecessary social alarm. [ABSTRACT FROM AUTHOR]

Deception detection is a topic covered in many psychology and communication courses. We designed and implemented an engaging class activity to facilitate the students' learning of several key concepts related to sender and receiver variability in lie detection. The pedagogical effectiveness of the activity was measured. In line with previous research, the students had difficulty acknowledging and correcting their own biases. However, the teaching activity was successful in correcting their general beliefs and facilitating learning. [ABSTRACT FROM AUTHOR]

Previous research has shown that in real-life situations people detect lies mostly from non-behavioral information (e.g., physical evidence, third-party information, confessions...) rather than from behavioral cues. Novotny et al. (J Nonverbal Behav 42:41–52, 2018. 10.1007/s10919-017-0263-2) argued that while lies are detected primarily from non-behavioral information, initial suspicion of a lie can be triggered primarily from behavioral cues. They conducted two studies and claimed support for their hypotheses. However, there are a number of problematic issues with Novotny et al.'s research and conclusions. We conducted analyses based on the frequencies and percentages they reported, and used meta-analytical techniques to combine their findings concerning discovered lies with those of previous research. The results show that lies are indeed detected from non-behavioral information more often than from behavioral cues. However, contrary to Novotny et al.'s assertions, suspicion is not triggered primarily from behavioral cues—rather, there is a trend in favor of non-behavioral information. Even so, behavioral cues play a bigger role in eliciting suspicion than in lie discovery. [ABSTRACT FROM AUTHOR]

This paper introduces a cutting-edge data architecture designed for a smart advertising context, prioritizing efficient data flow and performance, robust security, while guaranteeing data privacy and integrity. At the core of this study lies the application of federated learning (FL) as the primary methodology, which emphasizes the authenticity and privacy of data while promptly discarding irrelevant or fraudulent information. Our innovative data model employs a semi-random role assignment strategy based on a variety of criteria to efficiently collect and amalgamate data. The architecture is composed of model nodes, data nodes, and validator nodes, where the role of each node is determined by factors such as computational capability, interconnection quality, and historical performance records. A key feature of our proposed system is the selective engagement of a subset of nodes for modeling and validation, optimizing resource use and minimizing data loss. The AROUND social network platform serves as a real-world case study, illustrating the efficacy of our data architecture in a practical setting. Both simulated and real implementations of our architecture showcase its potential to dramatically curtail network traffic and average CPU usage, while preserving the accuracy of the FL model. Remarkably, the system is capable of achieving over a 50% reduction in both network traffic and average CPU usage even when the user count escalates by twenty-fold. The click rate, user engagement, and other parameters have also been evaluated, proving that the proposed architecture's advantages do not affect the smart advertising accuracy. These findings highlight the proposed architecture's capacity to scale efficiently and maintain high performance in smart advertising environments, making it a valuable contribution to the evolving landscape of digital marketing and FL. [ABSTRACT FROM AUTHOR]

The short communication addresses forced convection heat transfer of a viscous fluid flowing in a tube with fully developed laminar velocity and uniform entrance temperature that exchanges heat convection with a surrounding fluid. The idea is to implement the lumped model following the footsteps of the potent lumped model within unsteady heat conduction, instead of the differential model. The computed mean bulk temperatures of the viscous fluid expressed by a simple exponential function agrees well with the baseline numerical mean bulk temperatures when the internal fluid is air, water or crude oil and the external fluid is air for small values of the modified Biot numbers and maximum Reynolds numbers are satisfied. [ABSTRACT FROM AUTHOR]

In little over a decade, essential concepts in research on communication have become zombie concepts (Beck & Willms, 2004) and are no longer effective for understanding the profound transformation that has taken place with the arrival of the internet. Public sphere, deliberation, audiences, public..., the academic literature has oscillated between an initial optimism about the potential for strengthening democracy of communication technologies to a critical scepticism. This text reviews the academic literature with regard to the forms of social deliberation adopted in the context of the media and social networks and its impact on the public sphere. [ABSTRACT FROM AUTHOR]

In little over a decade, essential concepts in research on communication have become zombie concepts (Beck & Willms, 2004) and are no longer effective for understanding the profound transformation that has taken place with the arrival of the internet. Public sphere, deliberation, audiences, public... the academic literature has oscillated between an initial optimism about the potential for strengthening democracy of communication technologies to a critical scepticism. This text reviews the academic literature with regard to the forms of social deliberation adopted in the context of the media and social networks and its impact on the public sphere. [ABSTRACT FROM AUTHOR]

The production of quality, proximity and specialized contents is one of the main pathways for the survival of journalism. In this sense, specialization means an added value since it directly links to social interests. The current paper focuses on a field of growing interest such as gastronomy and food journalism. While television and the Internet have played a key role in the mediatisation of the gastronomy phenomenon, daily press still plays a crucial role in its popularization. The goal of this research is to review the food contents of the main Spanish newspapers - El Mundo, El País, El Periódico and La Vanguardia, during the period 2005-2015 -, in order to analyse the genres of food-based contents; to determine the sections that gather the narratives on gastronomy; and to categorize the topics developed. A content analysis approach is used as research method. Results reveal that food contents are found within different and specific spaces, and thus they count recently on a greater independency. Gastronomy is not anymore a minor field and media heavily contributes to the popularisation of the art of eating. Food-based contents are attractive for an audience who increasingly worries about a wide range of aspects like healthy diets or sustainable tourism practices. [ABSTRACT FROM AUTHOR]

The psychogenetically selected Roman high- (RHA) and low-avoidance (RLA) rats are being proposed as a valuable animal model of individual vulnerability to the two distinct neurobiological mechanisms of behavioral sensitization to psychostimulants, namely induction and expression. Most hallmarks of their divergent phenotypes are also found in the inbred RHA (RHA-I) and RLA (RLA-I) strains. For instance, they differ in the expression of sensitization to amphetamine. However, the pattern of spontaneous activity of the inbred rats seems to differ from that of outbred Roman strains. The present work shows the relevance of analyzing spontaneous activity as a covariant in order to determine the significance of day effect in the induction of behavioral sensitization to amphetamine (regime: 11 days, 1 mg/kg, i.p.) in the inbred strains and, for comparison, the standard low activity Sprague-Dawley (SD) strain. Our results also confirm that, in parallel to the outbred strains, only inbred RHA rats showed sensitization during the induction phase, here detectable from day 9 of treatment, while RLA-I and SD strains did not. Inbred RLA rats provide an interesting model to study individual resistance to sensitization, with nuances due to their underlying high spontaneous activity phenotype. [ABSTRACT FROM AUTHOR]

Within the current hybrid media system, in which the "old" and "new" media coexist, the role of social networks in the consumption of news has become increasingly important in recent years. Previous research has highlighted the importance and the transformational potential of user interactions in social networks in the traditional news cycle, when exchanging or discussing content related to news or public affairs, jeopardizing the traditional hegemony of the journalists and media as gatekeepers of public affairs. Our research follows a mixed methodological approach (survey plus focus groups) that reach relevant conclusions that expands the body of research about the role of news sites and social networks within the formulation of public opinion and its effects on audiences and journalism. Results showed how news sites and social networks, through links posted by friends, relatives, or acquaintances, facilitate people to access news outside their usual patterns of news consumption. Social networks, in this way, could break with the preestablished dynamics of selective exposure of individuals. [ABSTRACT FROM AUTHOR]

Papillary cystadenoma of the epididymis (PCE) is a rare benign epithelial tumor remarkable for its association with von Hippel-Lindau disease. A 12-year-old boy consulted for a progressive enlargement of the left testicle. At time of surgery, the whole epididymis was enlarged. Pathologic diagnosis was PCE with a focus on borderline malignancy. Scrotal left epididymectomy was performed. von Hippel-Lindau disease screening was negative. No relapse has been detected 2 years later. In case of atypical clinical examination of a hydrocele, unusual presentations such as PCE should be considered. The main differential diagnoses were adenomatoid tumor, nonpapillary cystadenoma, and metastatic clear cell renal carcinoma. [ABSTRACT FROM AUTHOR]

Animals play a profoundly important and intricate role in our lives today. Dogs have been human companions for thousands of years, but now they work to assist the disabled, and in combat and search and rescue situations. Farm animals are a critical part of sustainable agriculture today, and there is increasing consumer interest in humanely raised livestock, and how it impacts our health and environmental footprint. Wild animals are threatened with extinction by human induced factors, and shrinking and compromised habitats. There are many reasons, including societal and economic ones, to explore how new computing technologies can be used to ensure the welfare of animals in these settings. The goal of this review is to systematically survey the existing literature in smart computing and sensing technologies for domestic, farm, and wild animal welfare. We use a broad notion of animal welfare to refer to an assessment of whether animals are healthy, free of pain and suffering, and positively stimulated in their environment. Smart computing and sensing is also used in broad terms, to refer to systems that are not isolated but interconnected with communication networks, and capable of remote data collection, processing, exchange, and analysis. The findings of this review are expected to motivate future research in computer science and engineering, as well as contribute to data, information, and communication management for animal welfare. [ABSTRACT FROM AUTHOR]

The Sun is a main source of high energy neutrinos. These neutrinos appear as secondary particles after the Sun absorbs high-energy cosmic rays, that find there a low-density environment (much thinner than our atmosphere) where most secondary pions, kaons and muons can decay before they lose energy. The main uncertainty in a calculation of the solar neutrino flux is due to the effects of the magnetic fields on the absorption rate of charged cosmic rays. We use recent data from HAWC on the cosmic-ray shadow of the Sun to estimate this rate. We evaluate the solar neutrino flux and show that at 1 TeV it is over ten times larger than the atmospheric one at zenith θ z = 30 ∘ / 150 ∘ . The flux that we obtain has a distinct spectrum and flavor composition: it is harder and richer in antineutrinos and tau/electron neutrinos than the atmospheric background. This solar flux could be detected in current and upcoming neutrino telescopes. KM3NeT, in particular, looks very promising: it will see the Sun high in the sky (the atmospheric flux is lower there than near the horizon) and expects a very good angular resolution (the Sun’s radius is just 0.27°). [ABSTRACT FROM AUTHOR]

Circulation figures for print newspapers in Spain were historically low in 2017. However, digital media continues to grow, although only a handful of sites are financially profitable. The search for a profitable business model has superseded what is vital in journalism: quality information. In an attempt to identify the causes that have led to the current situation, this article describes the problems of pluralism in the Spanish media system. The lack of political independence and editorial autonomy are some of the problems identified. Media that are economically sustainable and politically independent are necessary for a truly democratic society. [ABSTRACT FROM AUTHOR]

Background: Deception detection research has shown that, in judging veracity, police officers are less truth biased than non-officers. However, previous researchers have normally used videotaped statements where an unknown (but presumably large) number of stereotypical or real deception cues are displayed by the senders. We examined non-officers, novice officers, and experienced officers' response tendencies in a more controlled situation where cue availability was severely restricted. Method: We used written vignettes describing either police-related or police-unrelated scenarios where the protagonist denied having committed a misdeed. Each vignette contained only two pieces of relevant information, one suggesting that the protagonist was lying and one suggesting that she or he was telling the truth. Results: Officers made fewer truth judgments than non-officers in judging police-relevant vignettes, but not in judging police-irrelevant vignettes. Both novice and experienced officers had greater judgmental confidence than non-officers. Conclusions: The findings are consistent with the Adaptive Lie Detection Theory (ALIED). Future research should continue to explore how the police relevance of the situation or task at hand influences novice and experienced officers' veracity judgments. [ABSTRACT FROM AUTHOR]

Background: Deception detection research has shown that, in judging veracity, police officers are less truth biased than non-officers. However, previous researchers have normally used videotaped statements where an unknown (but presumably large) number of stereotypical or real deception cues are displayed by the senders. We examined non-officers, novice officers, and experienced officers' response tendencies in a more controlled situation where cue availability was severely restricted. Method: We used written vignettes describing either police-related or police-unrelated scenarios where the protagonist denied having committed a misdeed. Each vignette contained only two pieces of relevant information, one suggesting that the protagonist was lying and one suggesting that she or he was telling the truth. Results: Officers made fewer truth judgments than non-officers in judging police-relevant vignettes, but not in judging police-irrelevant vignettes. Both novice and experienced officers had greater judgmental confidence than non-officers. Conclusions: The findings are consistent with the Adaptive Lie Detection Theory (ALIED). Future research should continue to explore how the police relevance of the situation or task at hand influences novice and experienced officers' veracity judgments. [ABSTRACT FROM AUTHOR]