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Atomic force microscopy was used to “fish” for binding reactions between a fibronectin-coated probe (i.e., substrate simulating an implant device) and each of 15 different isolates of Staphylococcus aureusobtained from either patients with an infected cardiac prosthesis (invasive group) or healthy human subjects (control group). There is a strong distinction (p0.01) in the binding-force signature observed for the invasive versus control populations. This observation suggests that a microorganism's “force taxonomy” may provide a fundamental and practical indicator of the pathogen-related risk that infections pose to patients with implanted medical devices. [ABSTRACT FROM AUTHOR]

The yield of physical qubits fabricated in the laboratory is much lower than that of classical transistors in production semiconductor fabrication. Actual implementations of quantum computers will be susceptible to loss in the form of physically faulty qubits. Though these physical faults must negatively affect the computation, we can deal with them by adapting error-correction schemes. In this paper we have simulated statically placed single-fault lattices and lattices with randomly placed faults at functional qubit yields of 80%, 90%, and 95%, showing practical performance of a defective surface code by employing actual circuit constructions and realistic errors on every gate, including identity gates. We extend Stace et al's superplaquettes solution against dynamic losses for the surface code to handle static losses such as physically faulty qubits [1]. The single-fault analysis shows that a static loss at the periphery of the lattice has less negative effect than a static loss at the center. The randomly faulty analysis shows that 95% yield is good enough to build a large-scale quantum computer. The local gate error rate threshold is , and a code distance of seven suppresses the residual error rate below the original error rate at . 90% yield is also good enough when we discard badly fabricated quantum computation chips, while 80% yield does not show enough error suppression even when discarding 90% of the chips. We evaluated several metrics for predicting chip performance, and found that the average of the product of the number of data qubits and the cycle time of a stabilizer measurement of stabilizers gave the strongest correlation with logical error rates. Our analysis will help with selecting usable quantum computation chips from among the pool of all fabricated chips. [ABSTRACT FROM AUTHOR]

Methicillin-resistant Staphylococcus aureus (MRSA) is a significant pathogen in both human and veterinary medicine. The importance of companion animals as reservoirs of human infections is currently unknown. The companion animals of 49 MRSA-infected outpatients (cases) were screened for MRSA carriage, and their bacterial isolates were compared with those of the infected patients using Pulsed-Field Gel Electrophoresis (PFGE). Rates of MRSA among the companion animals of MRSA-infected patients were compared to rates of MRSA among companion animals of pet guardians attending a ''veterinary wellness clinic'' (controls). MRSA was isolated from at least one companion animal in 4/49 (8.2%) households of MRSA-infected outpatients vs. none of the pets of the 50 uninfected human controls. Using PFGE, patient-pets MRSA isolates were identical for three pairs and discordant for one pair (suggested MRSA inter-specie transmission pvalue = 0.1175). These results suggest that companion animals of MRSA-infected patients can be culture-positive for MRSA, representing a potential source of infection or re-infection for humans. Further studies are required to better understand the epidemiology of MRSA human-animal inter-specie transmission. [ABSTRACT FROM AUTHOR]

: Objectives To evaluate the clinical characteristics, treatment and outcomes of patients with osteoarticular infections (OAIs) associated with Staphylococcus aureus bacteraemia (SAB). : Methods The clinical characteristics and outcomes for patients with OAI were described using a post hoc analysis of an open label, randomized trial comparing daptomycin with standard therapy (vancomycin or anti-staphylococcal penicillin with initial gentamicin) for the treatment of SAB. : Results OAI occurred in 32 of 121 patients (21 daptomycin and 11 standard therapy) with complicated SAB (18 septic arthritis, 9 vertebral osteomyelitis and 7 others). Two patients had osteomyelitis in more than one site. Success rates seen in two groups were as follows: vertebral osteomyelitis [3/5 (60%) daptomycin versus 0/2 (0%) comparator], septic arthritis [7/11 (64%) versus 3/5 (60%)], sternal osteomyelitis [3/3 (100%) versus 1/2 (50%)] and long bone osteomyelitis [0/1 (0%) versus 1/1 (100%)]. Success rates in both treatment groups improved with surgical therapy. Creatine phosphokinase elevations to >500 IU/L occurred in one patient on daptomycin who discontinued therapy, whereas renal impairment developed in three patients on standard therapy, two of whom discontinued therapy. Two patients treated with daptomycin and one patient on vancomycin had increases in S. aureus MICs to daptomycin and vancomycin, respectively. Three patients treated with daptomycin died following completion of therapy, with mortality attributed to multiple co-morbid conditions and inadequate debridement of OAIs in these patients. No deaths were reported in the standard therapy group. : Conclusions Daptomycin may be considered an alternative to standard therapy in the treatment of patients with complicated SAB and OAI. [ABSTRACT FROM AUTHOR]