Search

Objective: Cardiomyopathy (CMP) is a disorder associated with an increased risk of thromboembolism due to blood stasis, platelet activation and altered coagulation status. In this study, we aimed to investigate mean platelet volume (MPV) in patients with idiopathic CMP and ischemic CMP and to compare with those of the controls, and aimed to determine whether there is a relationship between MVP and echocardiographic parameters in patients with CMP. Methods: This study was designed as an observational cross-sectional study. A total of 100 subjects with idiopathic CMP (n=35), ischemic CMP (n=35) and controls (n=30) were included in the study. The MPV values were measured in all participants. All subjects underwent transthoracic echocardiography and angiographic evaluation. We used Chi-square test, one-way ANOVA and Pearson correlation tests for statistical analysis. Results: The MPV values were significantly higher in patients with idiopathic CMP and ischemic CMP than those of the controls (9.03±1.3 and 8.77±0.9 vs. 7.95±1.0 fl, respectively, p<0.001). The MPV values were although not statistically significant also tend to be higher in patients with idiopathic CMP than in patients with ischemic CMP (p=0.328). The MPV values were found to be positively correlated with left ventricular enddiastolic and end-systolic diameters (r=0.369, p<0.0001; r=0.325, p=0.001, respectively), and left atrial diameter (r=0.403, p<0.0001), but inversely correlated with left ventricular ejection fraction (r=-0.392, p<0.0001). Conclusion: Patients with idiopathic or ischemic CMP have higher MPV values indicating tendency to platelet aggregation regardless of the etiology, when compared to controls and an enlarged dysfunctional left ventricle may also be associated with higher MPV values. [ABSTRACT FROM AUTHOR]

Objective: The urocortin (Ucn) hormones have many important roles in the cardiovascular system. Apart from systolic dysfunction (SD), there is no sufficient data on the relationship between serum Ucn-2 and diastolic dysfunction (DD), or coronary artery disease (CAD). We investigated serum Ucn-2 levels in SD, DD, and CAD. Methods: In this observational cross-sectional study, study population was enrolled among outpatients who underwent coronary angiography with the pre-diagnosis of CAD. By examining the echocardiography 86 subjects were selected to study after coronary angiography. The subjects distributed over three groups to investigate the relationship between serum Ucn-2 and SD according to their ejection fraction (EF): subjects with moderate to severe SD (Group A, EF=33.6%), subjects with mild to moderate SD (Group B, EF=46.1%), and those without SD (Group C, EF=64.5%). Apart from these groups, the serum Ucn-2 levels were compared between subjects with and without DD (EF≥45%), and also compared between subjects with and without CAD (EF≥55%). Statistical analyses were performed using one-way ANOVA, Kruskal-Wallis, Chisquare, Mann-Whitney U, Spearman correlation and multiple regression analyses tests. Results: Serum Ucn-2 levels were decreased in Group A and were increased in Group B compared to Group C (9.4±3.4, 12.8±3.6 vs. 10.4±3.9 pg/ mL, respectively, p=0.003). Unlike SD; there was no significant difference in serum Ucn-2 levels between subjects with and without DD (11.4±4.1 vs 11.7±3.9 pg/mL, p=0.8) or CAD (10.7±4.7 vs 10.2±3.2 pg/mL, p=0.7). Conclusion: Ucn-2 is elevated in mild to moderate SD. But, DD (impaired relaxation pattern), or CAD (without myocardial infarction) seems to have no effect on Ucn-2 hormone levels. [ABSTRACT FROM AUTHOR]

Objective: Cardiomyopathy (CMP) is a disorder associated with an increased risk of thromboembolism due to blood stasis, platelet activation and altered coagulation status. In this study, we aimed to investigate mean platelet volume (MPV) in patients with idiopathic CMP and ischemic CMP and to compare with those of the controls, and aimed to determine whether there is a relationship between MVP and echocardiographic parameters in patients with CMP. Methods: This study was designed as an observational cross-sectional study. A total of 100 subjects with idiopathic CMP (n=35), ischemic CMP (n=35) and controls (n=30) were included in the study. The MPV values were measured in all participants. All subjects underwent transthoracic echocardiography and angiographic evaluation. We used Chi-square test, one-way ANOVA and Pearson correlation tests for statistical analysis. Results: The MPV values were significantly higher in patients with idiopathic CMP and ischemic CMP than those of the controls (9.03±1.3 and 8.77±0.9 vs. 7.95±1.0 fl, respectively, p<0.001). The MPV values were although not statistically significant also tend to be higher in patients with idiopathic CMP than in patients with ischemic CMP (p=0.328). The MPV values were found to be positively correlated with left ventricular end-diastolic and end-systolic diameters (r=0.369, p<0.0001; r=0.325, p=0.001, respectively), and left atrial diameter (r=0.403, p<0.0001), but inversely correlated with left ventricular ejection fraction (r=-0.392, p<0.0001). Conclusion: Patients with idiopathic or ischemic CMP have higher MPV values indicating tendency to platelet aggregation regardless of the etiology, when compared to controls and an enlarged dysfunctional left ventricle may also be associated with higher MPV values. [ABSTRACT FROM AUTHOR]