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BACKGROUND: Nowadays, there are increasing reports on the digitization and visualization system of acupuncture points for adults in traditional Chinese medicine, and the digitization and visualization system of acupuncture points for children in traditional Chinese medicine and the simulation system of acupuncture manipulation for Mongolian medicine training have been reported. However, there are no reports on relevant systems for children in Mongolian medicine. OBJECTIVE: To develop a simulation system of acupuncture points for children in Mongolian medicine, in the hope that it can be used for clinical teaching, manipulation practice and research on acupuncture safety. METHODS: Based on the tomographic anatomical dataset of preschool boys, a three-dimensional (3D) digital virtual anatomical model of children with multiple internal organs and tissues was constructed by using PhotoShop.2021 and Digihuman Reconstruction System software. The relevant annotation information database of 27 acupoints such as Dinghui acupoint of Mongolian medicine was compiled by the Unity database language. The Mongolian gold needle and silver needle were selected to record the acupuncture point teaching video on the 3D printed head and neck resin model of children. In Unity3D software, children’s anatomical model, acupoint annotation information database and acupuncture operation video were integrated and coded, and a 3D digital children’s Mongolian acupuncture acupoint visualization system integrating simulation acupuncture training, clinical teaching and acupuncture safety research was successfully created. RESULTS AND CONCLUSION: This study was based on real children’s specimens. In order to reduce the error of two-dimensional segmentation, the manual layer-by-layer segmentation section image method was used to ensure the accuracy of the 3D model to the greatest extent. The Digihuman Reconstruction System was used to extract and save the individual segmentation data while maximizing the accuracy of the 3D model. PhotoShop.2021 software was used to complete the 3D reconstruction of the outer skin of the head and neck of children and the internal bony structure, cervical spinal cord, blood vessels and nerves, muscles and ligaments. After 3D reconstruction, the basic morphology of each independent structure and the integrity of the overall contour were verified in MeshLab software and the final fine adjustment and anatomical position confirmation were conducted using 3-matic research 13.0 software. The real anatomical morphology of the head and neck of preschool children was successfully simulated and restored. Unity3D software was used to integrate the 3D model of children, acupuncture operation video and acupoint annotation database, and the 3D digital Mongolian acupuncture acupoint visualization system for children was successfully constructed. Based on the real continuous fault ultra-thin dataset of preschool boys in China, China’s first 3D digitization and visualization system of acupuncture points in the head and neck of children in Mongolian medicine was developed. Compared with the previous acupuncture soft works, this system is more suitable for the anatomical morphological development characteristics of Asian children, and has a high value of application in the fields of research on the safety of acupuncture in Mongolian medicine, clinical teaching and acupuncture simulation training. [ABSTRACT FROM AUTHOR]

Aiming at the problems of poor accuracy and narrow applicability of the existing key acupoint mining algorithms, a high specificity acupoint mining algorithm based on a 3‐node motif is proposed by introducing higher‐order interactions between multiple acupoints in the acupoint‐disease network. Comparing this algorithm with five other acupoint importance assessment algorithms in terms of resolution, network loss, and accuracy, the results show that the key acupoints identified by this algorithm have obvious destructive effects on the connectivity of the network, which indicates that the key acupoints are the core of the topology of acupoint‐disease network and have high synergistic co‑operation with other acupoints. The stability of this algorithm ensures the reliability of the key acupoints. From the perspective of the network topology and the high synergy between acupoints, the key acupoints found by the algorithm can be used as the core acupoints in the acupoint network, helping researchers to explore targeted and highly effective combinations of acupoints. [ABSTRACT FROM AUTHOR]

There are a variety of acupoint stimulation method for acupuncture and moxibustion to treat irritable bowel syndrome ( IBS ), involving 58 acupoints, but the main acupoints used have some commonalities. Ten of the most commonly used acupoints are mainly distributed in the dominant area of nerve segments closely related to the colon. The segmental connection between the acupoints and target organs determines the specificity of the acupoint effect. There is a limit to the number of acupoints in a prescription; selection of more acupoints will not necessarily lead to better effects. The acupuncture and moxibustion treatment effect in IBS did not show a significant improvement as the number of acupoints increased, it has little advantages to selected more than 6 acupoints, so the number of main acupoints used for acupuncture and moxibustion treatment of IBS can be controlled at 4 ~ 6. The significance of the compatibility of Tianshu(ST25) and Zusanli(ST36) may lie in some complementary effects produced by their different action targets, rather than the enhancement or superposition of the effect on common action targets. [ABSTRACT FROM AUTHOR]

BACKGROUND: Preliminary studies have found that peripheral facial nerve injury can cause changes in the expression of nerve growth factor, but the mechanism of electroacupuncture in the expression of nerve growth factor is unclear. OBJECTIVE: Based on a model of peripheral facial nerve injury in rabbits, to observe the effects of electroacupuncture on facial paralysis symptoms, morphology of facial nerve nuclei and expression of nerve growth factor and its receptor and to explore the mechanism of electroacupuncture in the treatment of peripheral facial nerve injury. METHODS: Forty-two New Zealand white rabbits (n=66) were randomized into normal group (n=6), model group (n=30) and electroacupuncture group (n=30). A crushing injury model of superior buccal branch of the right facial nerve was established in the latter two groups. There was no deal with normal group. After successful modeling, a needle was imbedded at Hegu in the electroacpuncture group, followed by electric stimulations with dilatational wave at Jiache, Dicang, Sibai, Yangbai, Yifeng, and Quanliao. No treatment was done in the model group. At 28 days of electroacupuncture, morphological changes of facial nerve nuclei were observed using hematoxylin-eosin staining and the expression of nerve growth factor, TrkA and p75NTR in facial nerve nuclei was detected using immunohistochemical staining. The expression of nerve growth factor, TrkA and p75NTR mRNA was detected using fluorescent quantitative PCR. The study protocol was approved by the Animal Ethics Committee of Southwest Medical University, with an approval No. 20170120001. RESULTS AND CONCLUSION: Hematoxylin-eosin staining results showed that the morphology of neurons recovered faster and more completely in the electroacupuncture group than the model group after surgery. The results of immunohistochemical staining showed that the average absorbance value of nerve growth factor in the electroacupuncture group was higher than that in the model group at every time point (P < 0.05), and the average absorbance value of TrkA and p75NTR in the electroacupuncture group was higher than that in the model group on the 7th, 14th, and 28th days after surgery (P < 0.05). Fluorescent quantitative PCR results revealed that the relative expression of nerve growth factor and p75NTR mRNA in the electroacupuncture group was higher than that in the model group on the 14th and 28th days after surgery (P < 0.05). The TrkA mRNA expression in the electroacupuncure group was higher than that in the model group on the 7th, 14th, and 28th days after surgery (P < 0.05). To conclude, electroacupuncture can improve the expression of nerve growth factor, TrkA, and p75NTR in facial nerve nuclei, and may promote the binding between nerve growth factor with TrkA and p75NTR, which may be the mechanism by which electroacupuncture promotes the repair of facial nerve injury. [ABSTRACT FROM AUTHOR]

The concepts "deqi"(literally, obtaining qi) and "qizhi"(literally, arrival of qi) are not unique to acupuncture, but also relevant in moxibustion. They refer to two characteristic manifestations in the process of moxibustion therapy. "Deqi" is mainly characterized by reddening of local skin accompanied with aching distention and hot pain caused by moxibustion, but these sensations might indicate the arrival of healthy qi or pathogenic qi, and thus may not necessarily suggest the arrival of qi that cures. On the other hand, "qizhi" often involves effective relief of superficial symptoms and improvement of pulse manifestation on the basis of "deqi" clinically. For different patterns, and with different moxibustion methods, acupoints, and supplementation/drainage manipulations, the characteristics and relationships between "deqi" and "qizhi" may vary. Understanding such subtle differences helps practitioners select the appropriate acupoints and methods according to different patterns during clinical moxibustion, and also assess the efficacy of moxibustion. [ABSTRACT FROM AUTHOR]

BACKGROUND: Increasing studies have shown that acupuncture has a significant effect on the treatment of neurogenic bladder after spinal cord injury, but there is no uniform acupuncture prescription standard for the treatment of this disease. OBJECTIVE: To investigate the rules of selecting acupoints in the treatment of neurogenic bladder after spinal cord injury with acupuncture and moxibustion. METHODS: Clinical literatures related to acupuncture treatment of neurogenic bladder after spinal cord injury were retrieved in China Knowledge Network, WanFang Data, VIP database and China Biology Medicine disc from 1989 to January 2020. Then, we established a database to perform descriptive analysis, relevance principle analysis and cluster analysis of the collected acupuncture prescriptions. RESULTS AND CONCLUSION: A total of 93 articles were included. Data collection and analysis showed that the acupoints and meridians with the highest frequency of neurogenic bladder after acupuncture treatment of spinal cord injury were Zhongji (CV3) (with the frequency of 55) and Bladder Meridian of Foot Taiyang (with the frequency of 161). Relevance principle analysis showed that combination of acupoints with strongest support is Guanyuan (CV4) and Zhongji (CV3). Cluster analysis of acupoints with the frequency ≥ 10 showed that acupoints could be divided into two categories. All these findings indicate that when acupuncture and moxibustion is used to treat neurogenic bladder after spinal cord injury, most of the acupoints along the meridians and local acupoints are selected. The results of relevance principle analysis and cluster analysis obtained from data mining can be used to select acupoints, match acupoints and reuse specific acupoints to improve the therapeutic efficacy. [ABSTRACT FROM AUTHOR]

Objective To observe the clinical effect of acupuncture plus acupoint application in treating post-cold cough.Methods Eighty outpatients conforming to the diagnostic criteria of post-cold cough in the outpatientd department of this hospital from January 2014 to May 2017 were selected and randomly divided into the treatment group and control group,40 cases in each group.The treatment group was coordinated by acupoint application after acupuncture,while the control group adopted Xuanfei Cough Mixture Syrup as the positive control drug.The cough VAS scores and efficacies were compared between the two groups.Results The cough VAS scores after 1,5 d treatment in the two groups were decreased compared with before treatment,the difference was statistically significant(P<0.05).The cough VAS score after 1 d treatment was significant lower than that in the control group,the difference between two groups was statistically significant(P<0.05),while the cough VAS score after 5 d treatment had no statistical difference between two groups(P>0.05).The effective rate in the treatment group was slightly higher than that in the control group,but the difference had no statistical significance(P>0.05).Conclusion Acupuncture plus acupoint application has rapid onset of effect and significant effect in treating post-cold cough. [ABSTRACT FROM AUTHOR]

目的　对比观察穴位电刺激与传统针刺疗法治疗青少年近视的效果。方法　将120例(229眼)青少年 近视患者随机分为两组，Ａ组60例(115眼)行穴位电刺激治疗，穴位包括攒竹、鱼腰、丝竹空、承泣、睛明、太阳、瞳 子#，每次治疗30ｍｉｎ，10次为一疗程。Ｂ组60例(114眼)行传统针刺治疗，主穴为攒竹、鱼腰、丝竹空、太阳、承 泣、睛明，配穴为风池、足三里、三阴交、光明。两组均以10次为一疗程，均治疗3个疗程。检查两组治疗前后视力、 屈光度、调节幅度和调节敏感度，并对比分析其疗效。结果　与治疗前比较，治疗后两组患者裸眼视力增加、近视 度数降低、调节幅度及灵敏度均增高(Ｐ均<0.01)。两组患者裸眼视力、屈光度、调节幅度、调节灵敏度治疗前后 差异无统计学意义(Ｐ均>0.05)。Ａ组显效19例、有效35例、无效6例，Ｂ组分别为24、31、5例，两组临床疗效差 异无统计学意义(Ｐ>0.05)。结论　穴位电刺激与传统针刺疗法均能显著改善青少年患者的近视病情，二者疗效 并无明显差别，但前者更简便易行。 [ABSTRACT FROM AUTHOR]

Objective To observe the clinical effect of acupuncture at Du Meridian on the cognitive dysfunction in delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) to provide a new method for treating this disease. Methods Fifty cases of DEACMP in our hospital from October 2011 to April 2014 were selected and randomly divided into the treatment group and control group,25 cases in each group. The control group was treated with the routine therapy of hyperbaric oxy-gen, hormone and cerebral protection, while on this basis the treatment group was given the acupuncture at Du Meridian. The treatment in the two groups lasted for continuous 8 weeks , with 6 d treatment and 1 d rest per week; the Mini-Mental State Examination(MMSE),Montreal Cognitive Assessment(MoCA) and latent period and amplitude of P300 were adopted to evaluate their cognition status after and before treatment. Results The scores of MMSE and MoCA after treatment in both groups were in-creased significantly, and the difference was statistically significant (P<0.05), moreover the treatment group was superior to the control group with statistical difference (P<0.05). The latent period of P300 after treatment in the two groups was significantly shortened, and the wave amplitude was significantly increased, the difference was statistically significant (P<0.05), moreover the treatment group was superior to the control group with statistical difference (P<0.05). The total effective rate in the acupuncture group was 88.00% (22/25), which in the control group was 68.00% (17/25),the difference between the two groups was statistically significant(P<0.05). Conclusion Acupuncture at Du Meridian can improve the cognitive dysfunction in DEACMP, P300 can serve as an evaluation index of cognitive dysfunction in DEACMP. Acupuncture at Du Meridian is a simple and effect method for treating DEACMP and is worthy of being clinically promoted and applied. [ABSTRACT FROM AUTHOR]