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Objective: To investigate the effects of Zhibai Dihuang Pill on the ovarian volume, follicular diameter and secondary sexual characteristics of ICPP girls. Results: From February 2019 to February 2021, 86 girls with ICPP treated in our hospital were ran- domly divided into control group (n=43) and observation group (n=43). The control group was given tripriline acetate, and the observa- tion group was given Zhibaidihuang pill in addition to the control group. Compare two groups clinical curative effect, the volume of uterus, ovarian volume and follicle diameter, sex hormone levels [follicle stimulating hormone (FSH), estradiol (E2) and luteinizing hor- mone (LH)], bone metabolism index level [ I type collagen amino peptide (P1NP), osteocalcin in the n-terminal molecular fragment (N-MID), collagen type I carboxyl end peptide crosslinking (beta CTX)] Adverse reactions. Results: After treatment, compared with the control group, the total effective rate of observation group was significantly higher (P<0.05), the uterine volume, ovarian volume and fol- licular diameter were significantly smaller (P<0.05), the levels of FSH, E 2, LH, P1NP, N-mid and β -CTX were significantly lower (P<0.05). There was no difference in the total incidence of adverse reactions between the two groups ( P>0.05). Conclusions: Zhibaidihuang pill has good clinical efficacy in the treatment of children with ICPP. It can reduce the advance changes of ovary and uterus, reduce the level of sex hormone, improve the level of bone metabolism index, and has good safety. [ABSTRACT FROM AUTHOR]