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In order to explore the pathogenicity and drug resistance mechanism of Proteus penneri from Cervus nippon, a pathogenic strain of Proteus penneri was isolated from the lung organs of dead Cervus nippon in Yunnan Wildlife Park. The whole genome of the isolated strain F2d was sequenced by the second generation sequencing technology, and the whole genome sequence of F2d obtained by sequencing was annotated into the databases of virulence factor, drug resistance gene, and metabolic pathway. The results of virulence factor database annotation showed that the strain contained virulence factors of adherence, nutritional/metabolic factor, motility, immune modulation and other types. The annotation results of the comprehensive antibiotic research database showed that strain F2d was resistant to many antibiotics such as β-lactams, aminoglycosides, tetracyclines and fluoroquinolones, and had many genes encoding the mechanism of antibiotic efflux. The annotation results of metabolic pathway database showed that the annotated genes were enriched in 42 pathways, and the number of metabolism related annotated genes was the largest, with a total of 2, 250 genes distributed in 12 pathways. Using whole genome sequencing technology to analyze the metabolic characteristics, pathogenicity and drug resistance of Proteus penneri F2d from deer can provide a theoretical basis for the prevention of Proteus penneri infection and the development of related drugs. [ABSTRACT FROM AUTHOR]