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In view of the high concentration of conventional pollutants in breeding wastewater, including heavy metals, antibiotics, hormones, and other toxic and harmful pollutants, microalgae transformation technology has shown great potential. In order to explore the effect, mechanism, and influencing factors of microalgae treatment of breeding wastewater, this paper summarized the removal effect and removal mechanism of microalgae on the main pollutants in breeding wastewater, analyzed the different influencing factors on the treatment effect of microalgae on breeding wastewater, and focused on the mechanism of microalgae and the removal efficiency of pollutants during different treatment process. The results showed that microalgae can remove conventional pollutants such as carbon, nitrogen, and phosphorus, from breeding wastewater through photosynthesis and assimilation and can remove heavy metals, antibiotics, suspended solids, hormones, and pathogenic bacteria through a series of biological processes. Meanwhile, the removal effect of microalgae on pollutants was restricted by the algae species type, inoculation concentration, temperature, light, and wastewater properties. Multi-algae coordination and immobilization treatment both improved the removal ability of microalgae, and algal bacteria symbiosis technology could make microalgae and bacteria mutually symbiosis, which could achieve the purpose of more efficient removal of pollutants. In summary, microalgae has great potential in the treatment of breeding wastewater, and optimal environmental conditions and appropriate treatment technology should be considered during the actual treatment process, so as to construct an efficient microalgae breeding wastewater purification system. [ABSTRACT FROM AUTHOR]

Based on the density functional theory (DFT), the surface properties of a single-atom Y adsorption on ITO (Indium Tin Oxide, ITO) surface were studied by first - principles calculations. According to the calculated results of total energy about the system, the stability adsorption site of single-atom Y (Single - atom Y supported on ITO, Y/ITO) is hole site. So, the model structure was designed based on the total energy. The adsorption properties of NO and CO gas molecules on ITO and Y/ITO surfaces were studied by first - principles calculations. The calculated results of adsorption energy and density of states for NO and CO gas molecules on ITO and Y/ITO surfaces suggests that the single-atom Y can improve the stability and adsorption property of ITO surface, and the adsorption behavior for NO and CO gas molecules on Y/ITO surfaces is a spontaneous exot hermic process. Also, the NO gas molecule is easy to be absorbed to Y/ITO surface. Therefore, the Y/ITO surface shows certain selectivity for NO. [ABSTRACT FROM AUTHOR]

The spatiotemporal pattern of non-agriculturalization can be accurately and rapidly captured for the rational formulation of land use and cultivated land protection. Remote sensing imagery has been more precise and efficient for the large-scale dynamic monitoring of cultivated land, with the advancements in feature extraction and classification. There are also different and feature variables during dynamic monitoring of cultivated land. In this study, Sentinel-2 satellite imagery was employed to monitor the non-agriculturalization of cultivated land. The experimental and validation zones were selected from the northern part of Xinjiang, a vital agricultural production base in China. The reclaimed areas were also in the Eighth Division of the Xinjiang Production and Construction Corps in Shihezi City. The data source was comprised of Sentinel-2 remote sensing images, covering the research area as of July 17, 2022, and August 16, 2020. The images were improved to facilitate the automatic extraction of information, according to the non-agricultural land use on cultivated land. Initially, the spectral indices and gray-level co-occurrence matrix were calculated to obtain 31 features, including spectral, spectral index, and texture features. Subsequently, Pearson correlation coefficients were computed for the eight band features, seven non-red edge spectral indices, and eight red edge spectral indices, leading to the removal of redundant features with weak classification and high correlation. Principal component analysis (PCA) was applied to extract the first three components of eight texture features. Feature importance scores were ranked using the random forest (RF) with the Gini index, resulting in the selection of optimal features: red, green, blue, narrow NIR (B8A), normalized difference vegetation index (NDVI), modified soil adjusted vegetation index (MSAVI), red-edge chlorophyll index (Clre), red-edge vegetation index (REDVI), triangular vegetation index (TVI), PCA1, PCA2 and PCA3 of texture features. 12 features and the original were selected to construct five classification schemes, including four optimal combinations (Scheme 1-3 and Scheme 5) and the original (Scheme 4). Seven classification algorithms were then utilized to evaluate: RF, artificial neural network (ANN), minimum distance (MID), maximum likelihood (MAL), mahalanobis distance (MAD), support vector machine (SVM), and Softmax. The results included: 1) The importance ranking of feature variables was as follows: band features, red edge spectral index features, non-red edge spectral index features, texture features. 2) Accuracy improvement depended mainly on the effective selection of multiple feature variables and algorithms. The two-stage model was constructed using Softmax. The highest accuracy was achieved with the optimal combination of feature variables, namely band + spectral index + texture features. The dimensionality of the feature variable was reduced to 12. The overall accuracy, average user's accuracy, average producer's accuracy, and Kappa coefficient were 94.92%, 95.16%, 93.15%, and 0.88, respectively. 3) A comparison of 2020 and 2022 data revealed that there was an area of 146.153 km² transitioning from cultivated land to non-agricultural use, while an area of 123.074 km² was transitioned from nonagricultural to cultivated land. Overall, the cultivated land decreased by 23.079 km² . In conclusion, the non-agriculturalization of cultivated land can provide technical support and references for the extraction of land cover information, particularly for the resource protection and sustainable utilization of cultivated land. [ABSTRACT FROM AUTHOR]

To explore the best intercropping method of millet and soybean under interfilm cultivation conditions in the loess hilly-gully region of northern Shaanxi, a single-factor randomized block experimental design was used to set up 5 treatments,including 2 rows of millet with 2 rows of soybean intercropping(I22), 2 rows of millet with 4 rows of soybean intercropping(I24),4 rows of millet with 2 rows of soybean intercropping(I42), millet in single cropping（SG）, and soybean in single cropping（SD）.Characteristics such as dry matter accumulation and distribution, interspecific competitiveness, and their effects on the yield of millet and soybean under different intercropping patterns were analyzed. The results showed as follows. The dry matter accumulation of millet was significantly increased by the three intercropping treatments, and it was significantly higher in the I24treatment than that in the I42 treatment. At the booting stage, the dry matter allocation ratio to leaves was greater than that to stems. At the maturity stage, the dry matter allocation ratio to spikes was greater than that to leaves and stems. The dry matter allocation ratios of the three intercropping treatments were significantly higher than those of the single cropping, with I24 and I22treatments being significantly higher than the I42 treatment. The dry matter accumulation of soybean was significantly increased by the three intercropping treatments. At the flowering stage, the dry matter allocation ratio to leaves was greater than that to stems.At the maturity stage, the allocation ratio to pods was greater than that to the stems and leaves. Among the three intercropping treatments, the pod allocation ratios were significantly higher than those of the single cropping, with no significant differences observed among the intercropping treatments themselves. The land equivalent ratio for the I24 and I42 intercropping treatments was 1.10 and 1.06, respectively, increasing land productivity by 6%-10% and highlighting the benefits of intercropping. The I22intercropping treatment had a land equivalent ratio of 1.00, indicating no intercropping advantage. Under the intercropping treatments, millet demonstrated stronger interspecific competitiveness（AG＞0） and a higher yield nutrient competition ratio（CRG＞1） than soybean. The I24 treatment had significantly lower interspecific competition than the I42 and I22 treatments. In conclusion,the 2 rows of millet with 2 rows of soybean intercropping was the most effective millet soybean intercropping method in the loess hilly-gully region of northern Shaanxi. MoreReset [ABSTRACT FROM AUTHOR]

To study the damage mechanism and ultrasonic properties of thermal-damaged engineered cementitious composites（ECC）, ultrasonic monitoring and compression tests were performed on ECC specimens exposed to high temperatures（20, 105, 250, 400, 600 and 800 ℃）. Results indicate that the changes in waveform amplitude, main frequency amplitude, energy, and compressive strength of thermal-damaged ECC are the same; the energy ratio in the 40～50 kHz band is the largest, which is about 15% of the total energy in the 0～300 kHz band. The wave velocities of ECC specimens heated from 20 to 250 ℃ show no significant changes, and decrease when heated above 400 ℃. The reason can be relate to free water vaporizes, hydration products decompose, and aggregate physical properties change at high temperature, which leads to the increasing of pore vapor pressure and damaging to the aggregate interfaces, thus the internal cracks in the ECC are generated and expanded. Scanning electron microscopy test results indicate that PVA fiber softens, melts, and vaporizes with increasing temperature. Voids and pores are generated in the ECC matrix and connect with cracks forming into networks, which are beneficial to the releasing of the pore vapor pressure and reducing the thermal damage of ECC. Results also show that the ultrasonic characteristics can effectively reflect the thermal damage evolution process in the ECC. [ABSTRACT FROM AUTHOR]

Objective·To investigate the anti-cancer effects of DNA nanoflowers (DF) loaded with horseradish peroxidase (HRP) and doxorubicin (DOX) on mice Lewis lung carcinoma (LLC) cells. Methods·The DF loaded with HRP (HRP-DF) was synthesized by rolling circle amplification (RCA) reaction and DOX was loaded to prepare DOX/HRP-DF, the physical properties of which were detected by scanning electron microscopy and laser particle sizer. In vitro drug release capacity of DOX/HRP-DF was tested with acid buffer solution. The safety of DOX/HRP-DF was evaluated by CCK-8 assay to detect the cytotoxicity of 16HBE cells treated with DOX/HRP-DF and free DOX at different time points. Under anoxic conditions, the oxygen production capacity of DOX/HRP-DF in LLC cells was detected by using the oxygen-sensitive probe, and the effects of different dosages of free DOX, DOX-DF and DOX/HRP-DF on the proliferation capacity of LLC cells were examined by CCK-8 assay. The effects of DOX/HRP-DF on the migration and invasion of LLC cells were detected by scratching assay and Transwell assay in the experimental group treated with different dosages of DOX/HRP-DF and the control group treated with Phosphate Buffered Saline (PBS). Results·DOX/HRP-DF were successfully prepared and observed as flower-like structures under scanning electron microscopy with uniform size. The average diameter and potential of DOX/HRP-DF were (415.90±9.32) nm and (-17.43±1.20) mV, respectively. DOX/HRP-DF had a DOX loading of (38.19±0.39)% with good pH-sensitive drug release properties. DOX/HRP-DF could significantly reduce the toxic effect of DOX on human normal cells. The results of Laser confocal microscopy showed that DOX/HRP-DF could effectively alleviate the hypoxic condition of LLC cells. CCK-8 assay results showed that the proliferation rate of LLC cells in the DOX/HRP-DF group was significantly lower in a dose-dependent manner, compared to the free DOX and DOX-DF groups (P<0.05). The results of scratching assay showed that the scratch healing rate of the DOX/HRP-DF group was lower than that of PBS group in a dose-dependent manner (P<0.05). Transwell experiments showed the number of LLC cells passing through Matrigel gel in the DOX/HRP-DF group was reduced in a dose-dependent manner, compared with the PBS group (P< 0.05). Conclusion·The successfully prepared DOX/HRP-DF could effectively deliver drugs, and alleviate hypoxia in the tumor microenvironment, and significantly inhibit the proliferation, migration and invasion ability of LLC cells, which is expected to provide new ideas for lung cancer treatment. [ABSTRACT FROM AUTHOR]

Achieving the goals of peaking carbon dioxide emissions and carbon neutrality is the requirement of the new era to improve the implementation of the Mineral Resources Law. As the basic law for the development, utilization, and protection of mineral resources in China, the Mineral Resources Law is currently under major revision, which would be supplemented to provide strong legal support for the realization of the 'dual carbon' goals. The revision of the Mineral Resources Law provides legislative options to respond to the realization of the 'dual carbon' goals from legislative concepts, mineral resource exploration, mining, and ecological restoration of mining areas. In terms of legislative concepts, the implications of the 'dual carbon' goals contained in the idea of ecological civilization construction have a fundamental impact on the revision and application of the Mineral Resources Law. The realization of the 'dual carbon' goals is a necessity of the application of the Xi Jinping Thought on Ecological Civilization in the mining field, and it is the basic requirement for the high-quality development of mineral resources. In terms of exploration, ensuring investment in mineral resource exploration and determining the list of important mineral resources are key institutional starting points. The former highlights the modification of the rules for transferring the mineral exploration right to the mining right rule and the simplification of the transferring process, thus resetting the revenue system for the assignment of mineral exploration right and highlighting the competitive cost. The latter clarifies the identification of associated mineral resources, avoids the transformation of 'comprehensive utilization' into 'illegal mining', and pays attention to the system optimization of fiscal and taxation support for the comprehensive utilization of mineral resources. In terms of mining, although carbon emissions during the mining of mineral resources cannot be avoided, the improvement of resource utilization is a key measure to reduce carbon emissions and improve the safety of mineral resources, and an important path to promote the achievement of the 'dual carbon' goals from the perspectives of the environment and resources. In terms of ecological restoration of mining areas, it is necessary to positively respond to the negative externalities that are unavoidable in the development and utilization of mineral resources. It is also the focus of China' s mining administration practice and the construction of the mineral resource laws. It is of great importance to highlight the construction of a diversified and multi-layered legal system for the ecological restoration of mining areas, maintain interaction with other legal sources, and pay specific attention to the compilation of the Environmental Code. [ABSTRACT FROM AUTHOR]

目的通过分析上海市医疗机构药学人员的学历、专业、岗位职能情•况, 了解医疗机掏药学人员的学历、 专业结构与岗位要求的匹配度及其变化趋势, 为提高上海市药学人员岗位适应水平和岗位职能培训提供参考。 方法采用自拟的"2020年上海市医疗机构药学人员信息调查表", 由上海市16个区的医院(含市级医疗机构)和 社区卫生服务中心电子填报本机枸内药学人员的数据信息。结果上海市药学人员入职时学历普遍较低, 以矢专 为主(3 526人, 33.15%),近半数的药学人员进入机构后学历水平有不同程度的提升, 专业仍以药学为主, 入职后 药学、临床药学、应用药学、药事管理4个专业的药学人员比例有所增加。临床药师在学历、专业的要求比较高, 超过80%的临床药师均具有本科及以上学历。结论需加强药学人员的培训, 以更加适应实际的岗位工作要求。艦 床药师对学历水平要求较高, 入职后的药学人员仍要通过继续教育等方式不斷提高专业知识水平. [ABSTRACT FROM AUTHOR]

Accurate and rapid acquisition of crop and weed category information has been one of the most important steps for automatic weeding operations. In this research, a weed recognition model was proposed using improved DenseNet, particularly for the efficient and accurate identification of weeds in crop fields under complex environments. Firstly, data augmentation was utilized to expand the number of images for the collected crop and weed pictures, thereby increasing the diversity of data, but avoiding network learning irrelevant features, and finally enhancing the recognition ability of the model. Secondly, Efficient Channel Attention (ECA) was introduced into the DenseNet-121 network after each convolutional layer. As such, the accuracy of weed recognition was improved to effectively focus the attention on the weeds in the main part of images, where the weight of important features increased further to strengthen the weed features, but to suppress the extraction of background features. At the same time, DropBlock regularization was also added after each DenseBlock block, further to randomly hide some feature maps and noise. Correspondingly, the generalization, robustness, and adaptability of the model were improved to identify different types of weeds. Finally, taking corn seedlings and six types of associated weeds in natural environments as samples, a comparison test was performed on the test set using VGG-16, ResNet-50, and the unimproved DenseNet-121 model, where the batch size was 64, and the initial learning rate was 0.01. More importantly, an SGD optimizer was used to train the CNN model, and the batch size was set to 64, the initial learning rate was set to 0.01, and the VGG-16, ResNet-50 and the unimproved DenseNet-121 model was compared and tested on the test set.. The results show that the improved DenseNet model presented the best performance, where the model size was 26.55 MB, the single image took 0.23 s, and the average recognition accuracy reached 98.63%, increased by 2.09% before the improvement. It infers that the overall performance of improved DenseNet-121 was significantly higher than that of VGG-16 and ResNet-50. Class Activation Mapping (CAM) was also used to visualize the heat map for the subsequent comparison. The improved DenseNet decision was obtained, where the important weight position of classification was more focused on the main part of weeds than before. Specifically, the category judgment probability was 0.99, significantly higher than that of the unimproved model, further verifying the effectiveness of the improved model. Consequently, the DenseNet network with ECA attention and DropBlock regularization can widely be expected to improve the recognition accuracy and the generalization of the model, further to ensure the efficient and accurate recognition of weeds in complex environments. The findings can provide a strong reference for the accurate identification of other crops and associated weeds. The versatility of the model in weed identification can also be improved for the technical development of intelligent weeding robots. [ABSTRACT FROM AUTHOR]

Metabolomics of biological sample has been a hot topic in the field of mass spectrometry in recent years. The components of biological samples are complex, among which alcohols are very important. Alcohol metabolites mainly include fatty alcohols, sugars, phenols, glycerides and sterols. These metabolites undertake crucial physiological functions in vivo. However, due to the low polarity of most alcohol metabolites and the lack of ionizable groups, their research is relatively less than other types of metabolites such as amines and acids in mass spectrometry field. Chemical derivatization is a powerful sample pre-treatment technology, which through the design of organic chemical reagents targeting a functional group to react with the metabolites of interest in the sample, so as to load the derivatization reagent group into the molecular skeleton of the analyte. The addition of derivatization reagent group can change the physicochemical properties of the analyte, greatly improve its ionization efficiency in mass spectrometry. As a result, a rapid and sensitive method for the detection of metabolites can be established. The application of chemical derivatization technology in the detection and analysis of alcohol metabolites by mass spectrometry can greatly improve their mass spectrometry behavior, and offer help for the physiological and pathological research of alcohol metabolites. With the consistent efforts of researchers, mass spectrometry derivatization methods for alcohol metabolites are emerging, and these proposed methods have been applied into various types of mass spectrometry instruments, including gas chromatography-mass spectrometry (GC-MS), liquid chromatography-mass spectrometry (LC-MS), matrix assisted laser desorption mass spectrometry (MALDI-MS) and direct analysis mass spectrometry. The limit of detection (LOD) and limit of quantification (LOQ) of alcohol metabolites were also significantly reduced by the establishment of various mass spectrometry derivatization methods. In this paper, the chemical derivatization reactions for alcohol metabolites published in recent years were summarized, and the qualitative and quantitative methods and rapid screening methods for alcohol metabolites based on these derivatization reactions were briefly introduced. [ABSTRACT FROM AUTHOR]

The Zr'1+-NiJ+ co-doped barium ferrites (Ba(ZrNi)xOu)无=;0.6-0・9) were prepared by solgel method and sintered at 1 200-1 400 °C. The influences of doping ratio and sintering temperature on crystal structure, micro morphology, electromagnetic performance and micro wave absorption property of M-type barium ferrite have been studied in detail. The results show that the crystal structure has no change with the increment of doping amount and sintering temperature. All the samples form single-phase flake Zr1+-Ni'+ co-doped barium ferrite. The grain size barely changes with the increasing Zr1+-NiJ+ content whereas increases from 1 00一300 nm to 1一2 mm by improving the sintering temperature. The natural resonance peak can be observed in all the samples, and the intensities of the peaks are seen to diminish gradually with the doping amount increasing. Meanwhile, the permittivity enhances obviously with the sintering temperature improving. Eventually, the sample with x =0.6 sintered at 1 400 °C achieves the best micro wave absorption performance with broad bandwidth of 5.22 GHz (8.62-1 3.84 GHz) and reflection loss of --1 6.4 dB at matching thickness of 3.25 mm. [ABSTRACT FROM AUTHOR]

BACKGROUND: Swimming is an important non-pharmacological treatment for knee osteoarthritis, which can effectively alleviate the disease. However, the effect and mechanism of swimming on senile knee osteoarthritis are still unclear. OBJECTIVE: To investigate the effect of swimming exercise on the articular cartilage of aged mice with knee osteoarthritis. METHODS: Six 3-month-old male C57BL/6 mice were selected as the young group, and twelve 18-month-old male C57BL/6 mice were randomized into the aged group and the swimming group, with six mice in each group. Mice in the swimming group received adaptive swimming for 1 week and formal swimming for 8 weeks. After the intervention, stride length analysis and sampling were performed in each group. The total number of leukocytes and lymphocytes in peripheral blood was detected by blood routine examinations. The morphology of the articular cartilage was observed by hematoxylin-eosin and safranin O-fast green staining. Chondrocyte counts and the modified Mankin’s score were used to evaluate the degree of articular cartilage damage. The protein and mRNA expressions of type II collagen, aggrecan and matrix metalloproteinase 13 in articular cartilage were detected by immunohistochemical staining and RT-qPCR. RESULTS AND CONCLUSION: Compared with the young group, the mice in the aged group showed significantly decreased stride length (P < 0.05), significantly increased numbers of peripheral leukocytes and lymphocytes (P < 0.05), significantly decreased count of chondrocytes (P < 0.05), significantly increased modified Mankin’s score (P < 0.05), significantly decreased protein and mRNA expression of type II collagen and aggreca (P < 0.05), and significantly increased matrix metalloproteinase 13 expression (P < 0.05). Moreover, hematoxylin-eosin and safranin O-fast green staining showed the uneven surface of the articular cartilage, abnormal chondrocytes, and proteoglycan loss in the aged group. Compared with the aged group, swimming exercise significantly improved the stride length of mice (P < 0.05), decreased the count of peripheral blood lymphocytes (P < 0.05), increased the count of chondrocytes (P < 0.05), decreased the modified Mankin’s score (P < 0.05), increased the protein and mRNA expression of type II collagen and aggrecan (P < 0.05), and decreased the expression of matrix metalloproteinase 13 (P < 0.05). Hematoxylin-eosin and safranin O-fast green staining showed that the articular surface of mice in the swimming group was smooth, chondrocytes were normal, and proteoglycan loss was less. All these findings indicate that swimming exercise can reduce the number of inflammatory cells in the blood of aged mice, improve articular chondrocytes, matrix composition and cartilage tissue morphology; thus, it has a protective effect on the cartilage of aged mice with knee osteoarthritis. [ABSTRACT FROM AUTHOR]

Corrosion defects of various forms can occur over time in pipelines, and the interaction between adjacent corrosion defects can impact the pipeline’ s failure pressure. However, there has been no comprehensive study on the interaction limit spacing of pipelines with asymmetric corrosion defects. In light of this, the finite element method was employed to investigate the interaction limit spacing of pipes with asymmetric double corrosion defects. Initially, the reliability of the finite element modeling of multi-corrosion defects was validated through the Benjamin blasting test. Building upon this, length asymmetric corrosion defects and depth asymmetric corrosion defects in the axial direction, as well as length asymmetric corrosion defects and depth asymmetric corrosion defects in the circumferential direction was examinesd. The findings indicate that the interaction limit spacing of asymmetric corrosion defects obtained in this article is more accurate in evaluating asymmetric corrosion defects. [ABSTRACT FROM AUTHOR]

Objective: To explore the application method and effect of ultrasound-guided epidural block in elderly hip replacement surgery. Methods: From June 2017 to May 2020, 112 cases of elderly patients who underwent hip replacement surgery in our hospital were selected as the research object, and the patients were divided into study group and control group of 56 cases in each groups accorded to the random number table method. The study group was given ultrasound-guided epidural block, and the control group was given traditional intravenous continuous analgesia. The two groups were given general anesthesia induction and maintenance, and the analgesic effects and patient's postoperative recovery were recorded. Results: There were no significant difference in gender, age, anesthesia time, operation time and intraoperative bleeding compared between the two groups (P>0.05). The postoperative hospital stay in the study group were significantly shorter than that in the control group (P<0.05). The visual analogue scale/score (VAS) scores of pain in the two groups at 1 d, 3 d and 7 d after surgery were significantly lower than those at 1d before operation, and the study groups were lower than the control group(P<0.05). The hip joint mobility of the study group at 1 d, 3 d and 7 d after surgery were significantly higher than that of the control group (P<0.05). The contents of Substance P (SP) and Prostaglandin E2 (Prostaglandin E2, PGE2) in the two groups at 1 d, 3 d and 7 d after surgery were significantly higher than those at 1 d before operation, and the study groups were lower than the control group(P<0.05). Conclusion: The application of ultrasound-guided epidural block in elderly hip replacement surgery can inhibit the release of serum SP and PGE2, can relieve postoperative pain, promote the recovery of hip function, and shorten the recovery time of patient [ABSTRACT FROM AUTHOR]

bjective To investigate HBV RNA level in patients with HBV-related hepatocellular carcinoma after long-term antiviral therapy and its clinical significance. Methods A total of 60 patients with HBV-related hepatocellular carcinoma who were admitted to Tianjin Second People's Hospital from June 2019 to August 2020 were enrolled in this study. These patients received antiviral therapy with nucleos(t)ide analogues (NAs) for at least two years, and high-sensitivity HBV DNA detection showed a HBV RNA level of < 20 IU/mL at least twice at an interval of 3 months. Liver function, HBV serum markers, and HBV RNA level were measured for all patients. The Kruskal-Wallis H test was used for comparison between multiple groups, and the Wilcoxon rank-sum test was used for comparison between two groups; a Pearson correlation analysis was used to investigate the influencing factors for HBV RNA. Results Among the 60 patients with HBV-related hepatocellualr carcinoma who received long-term antiviral treatment, 9 (15%) tested positive for HBV RNA. According to the level of alpha-fetoprotein (AFP), the patients were divided into AFP positive group and AFP negative group, and there was no significant difference in HBV RNA level between the two groups [0(0-3.57) vs 0(0-2.00), Z=-1.474, P=0.141). According to Barcelona Clinic Liver Cancer (BCLC) stage, they were divided into BCLC stage A group and BCLC stage B+C+D group, and there was no significant difference in HBV RNA level between the two groups [0(0-2.0) vs 0(0-2.0), Z=-0.607, P=0.544]. According to HBeAg level, the patients were divided into HBeAg positive group and HBeAg negative group, and there was a significant difference in HBV RNA level between the two groups [2.99(0-4.80) vs 0(0-0.50), Z=-3.400, P=0.001]. According to the titer of HBsAg, they were divided into HBsAg≤100 IU/mL group, 100 IU/mL < HBsAg < 1500 IU/mL group, and HBsAg ≥1500 IU/mL group, and there was a significant difference in HBV RNA level between the three groups [0(0-0.0) vs 0(0-0.20) vs 2.00(0.0-4.54), H=-7.899, P=0.019]. A Pearson correlation analysis was performed for age, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transpeptidase, alkaline phosphatase, alpha-fetoprotein, HBsAg, and HBeAg, and the results showed that HBsAg level was correlated with HBV RNA quantification (r=0.292, P < 0.05). Conclusion In patients with HBV-related hepatocellualr carcinoma receiving long-term antiviral therapy with NAs, HBV RNA can still be detected after HBV DNA is lower than the lower limit of detection. HBsAg titer may be correlated with serum HBV RNA level. [ABSTRACT FROM AUTHOR]

g-C3N4(CN(32))was prepared by mixing urea and melamine, and then a series of Ag3VO4/CN(32) composites were successfully synthesized by chemical precipitation method. The crystalline and composition, morphology, functional groups and optical absorption performance of the synthesized samples were characterized by XRD, SEM, FT-IR and UV-Vis. Their photocatalytic performance in visible light was investigated through the experiment of microcystins（MC-LR） degradation. The results showed that Ag3VO4 was successfully loaded on the surface of CN(32), and the light absorption intensity of the composites was significantly improved compared with that of CN（32）. The photocatalytic activity of Ag3VO4/CN(32) for MC-LR degradation was optimized. When the mass percentage of Ag3VO4 was 20% in the Ag3VO4/CN(32)composite, the degradation rate reached 85.4% within 100 min, which was 10 times higher than that of CN(32). Furthermore, MC-LR degradation by Ag3VO4/CN(32) showed a good compliance with the pseudo-first-order kinetic model. The enhanced photocatalytic performance of Ag3VO4/CN(32)composite was ascribed to the highly separation rate of electrons and holes. [ABSTRACT FROM AUTHOR]

Copper oxide nanowires were synthesized on copper foil substrate by anodic oxidation method followed by a simple annealing process. The lithium-ion battery without binder was prepared by using it as anode material. The effect of the anodizing time on the morphology and electrochemical properties of the materials was studied. At the rate of 1 C, the CuO nanowires array with anodizing time of 1000 s showed the highest first discharge specific capacity of 1172 mAh/g and the reversible specific capacity of 594 mAh/g. The reversible specific capacity after 500 circles was 607.6 mAh/g, and the reversible capacity retention rate was 102.3%. It proves that the cross-linked 3D CuO nanowire network could provide a stable structure for lithium ion insertion and removal, which could effectively solve the volume expansion problem of copper oxide materials as anode materials for lithium ion batteries, and exhibit excellent rate performance and cycle life. [ABSTRACT FROM AUTHOR]

Based on the first principle calculation method, the relevant properties of V2C（MXene） containing vacancy defects modified with monoatomic Al at different sites were systematically studied. The results showed that after geometric optimization, the surface energy of stable V2C containing vacancy defects was-3075.53 J/m~2, the adsorption energy of monoatomic Al-modified intrinsic V2C monoatomic was 1.5511 eV, and the adsorption energy of monoatomic Al-modified V2C containing vacancy defects was-2.0763 eV, suggesting that the structural stability of V2C containing vacancy defects can be improved significantly due to the modification of monatomic Al. Further study on the density of states（DOS）, partial density of states（PDOS） and hydrogen absorption capacity revealed that the DOS and PDOS of all systems crossed the Fermi level, presenting high metallicity. The adsorption energy of V2C for H2 gas molecules was-7.5867 eV, while that of V2C containing vacancy defects and monatomic Al-modified V2C containing vacancy defects for H2 gas molecules was only-0.9851eV and-2.7130 eV respectively, indicating that the adsorption performance of V2C for H2 gas molecules is not further improved. This study provides certain theoretical guidance for the research and development of hydrogen storage materials. [ABSTRACT FROM AUTHOR]

Myocardial Fibrosis（MF） seriously endangers human health. Extracorporeal Shock Wave Therapy can lead to a variety of biochemical functions, by promoting angiogenesis factor and its receptor in vivo expression， promoting the establishment of angiogenesis and collateral circulation in ischemic tissue，inhibiting the oxidative stress in ischemic tissue, and relieving the ventricular remodeling process after acute myocardial infarction （AMI）， and by reducing the fiber cell number to influence the myocardial fibrosis after myocardial infarction. Extracorporeal Shock Wave Therapy can achieve the aim of relieving cardiac remodeling. A large number of previous studies has reported that CSWT showed good tolerance in CAD patients . In the process of shock wave treatment and after treatment, patients had no aggravated angina symptoms, no complications such as worsening heart failure or myocardial injury, and no thoracotomy or interventional surgery is required. Extracorporeal Shock Wave Therapy is easy to repeat and easy for the patient to accept. CSWT has been confirmed as a noninvasive, safe, operatable, effective and repeatable repeat newtherapy to alleviate myocardial fibrosis. [ABSTRACT FROM AUTHOR]

Based on the First-principle calculation method, the models of intrinsic graphene, vacancy graphene and yttrium (Y) doped vacancy graphene were established. The adsorption processes of CO and NO on the surface of the above mentioned three types of graphene were calculated. The influence of doping Y on the adsorption performance of CO and NO gas was studied from surface energy, adsorption structure, adsorption energy and state density. The results showed that the adsorptions of CO, NO on intrinsic graphene are weak physical adsorptions. After Doping Y, the adsorption effect of CO and NO on its surface are markedly enhanced, and the maximum adsorption energies are 7.414 eV and 6.702 eV respectively, and the adsorption type changed to chemical adsorption. The doping Y increases the number of active electrons near the Fermi level of the vacancy graphene, and the system changes from semi-metal to metal after NO adsorption, which can provide theoretical support for the development of better graphene gas sensitive materials. [ABSTRACT FROM AUTHOR]

Diesel pool fire experiments on different diesel water ratios were conducted under various ventilation conditions. The flame temperature， the radiation heat flux and the mass loss rate were measured， and the fire splash phenomenon was observed in order to analyze the combustion characteristics and the diesel pool fire spread rules. Results show that the diesel pool fire with 1∶1 diesel water ratio is always in the boilover status and the splash continuously occurs in the fire developed stage under natural ventilation conditions; both the temperature and the radiant heat flux reach the maximum value in the continuous splash. With the decreasing of the diesel water ratio， the flame temperature and the radiant heat flux are reduced and the frequency and the intensity of splashing are reduced either. If the air velocity is increased to 1.0m/s， the combustion is intensified significantly by the ventilation speed and the duration time of the developed stage of fire is increased. When the air velocity is further increased to 1.5m/s， the pool fire is hard to reach the developed stage or only last for a short time， which illustrates the negative impact of ventilation velocity increasing. [ABSTRACT FROM AUTHOR]

The arthropod in eight typical campus vegetations of Neosinocalamus affinis, Fatsia japonica, Prunus cerasifera, Osmanthus fragrans, Cycas revoluta Thunb, Loropetalum chinense, Ligustrum quihoui and Rhododendron pulchrum was investigated and identified to provide the basic data for protection of arthropod diversity in urban ecosystem. Results: There were 934 arthropods(91 groups, 77 families, 17 orders and 3 classes) in eight typical campus vegetations of Guiyang University and the dominant groups were Araneae and Cicadellidae. There are significant differences(P < 0. 01) in group number, individual number, Shannon-Wiener index(H), diversity index(D) and Simpson index(C) among different vegetations but there is no difference(P > 0. 05) in Pielou index(E) among different vegetation variation had great influence on the similarity of common arthropod groups and rare arthropod community composition. There was significant difference in community composition and diversity of arthropod among different vegetations. Vegetation variation and human disturbance were the key factors to arthropod distribution in Guiyang university. [ABSTRACT FROM AUTHOR]

Objective To assess the bone thicknesses of the infrazygomatic crest in the adult patients with different vertical skeletal patterns of skeletal classⅠmalocclusion based on cone-beam computed tomography (CBCT), and to provide the basis for the choice of clinical treatment methods for the orthodontists. Methods A total of 90 adult patients with skeletal class I malocclusion were selected and divided into low angle group, average angle group, and high angle group, and there were 30 patients in each group. The buccal bone thickness of the patients at different vertical levels and proximal, distal and mesial levels were detected on the CBCT images and the effective bone volume was measured at buccal alveolar bone thickness ≥ 3 mm with the 50°, 60°and 70° implantation angles. Results In different vertical sections, except for the proximal mesiobuccal root level of the maxillary first molar (U6mb), the buccal alveolar bone thickness was increased gradually from the top of the alveolar ridge to the root side (P<0.05) . At different proximal, distal and mesial levels, the buccal bone thickness of the patients was gradually increased from the proximal to the distal mesial direction in all levels except U6mb (P<0.05) . The maximum buccal bone thickness of the patients was 11 mm from the top of the alveolar ridge at the proximal mesiobuccal root of the maxillary second molar (U7mb) ； the minimum buccal bone thickness was 7 mm from the top of the alveolar ridge at U6mb.There was significant difference in the buccal bone thickness of the patients with different vertical bone facial types (P<0.05), the buccal bone thickness of the patients in low angle group was higher than those in average angle group and high angle group (P<0.05), and the buccal bone thickness of the patients in average angle group was higher than that in high angle group (P<0.05) .Among the patients in low angle group, there were significant differences in bone thicknesses between the distal mesiobuccal root of the maxillary first molar and the proximal mesiobuccal root of the maxillary second molar (U6db-U7mb) at from the top of the alveolar crest was 7 mm, at U7mb when the distance from the top of the alveolar crest was 7 mm and 9 mm, at U6mb-U6db when the distance from the top of the alveolar crest was 11 mm at three angles (P<0.05) .The bone thickness was ≥6 mm at U6db-U7mb, when the distance from the top of the alveolar crest was 7 mm at three angles, and when the distance from the top of the alveolar crest was 9 mm at 70° at U7mb.Among the patients in average angle group, there were significant differences in the bone thicknesses between U6db-U7mb at 9 mm from the top of the alveolar crest, U7mb at 9 mm and 11 mm from the top of the alveolar crest at three implantation angles, and the bone thickness ≥6 mm at U7mb when the distance from the top of the alveolar crest at three angles was 7 mm and at U7mb when the distance from the top of the alveolar crest was 9 mm at 70° (P<0.05). Among the patients in high angle group, there were significant differences in bone thickness between U6db-U7mb 11 mm from the top of the alveolar ridge and U7mb 11 mm from the top of the alveolar ridge at three implantation angles (P<0.05) . The thicknesses of bone implantation at different angles could be ranked as follows, 70°>50°>60° in all dimensions. Conclusion There are differences in the buccal bone thickness in the zygomatic crest area among the adult patients with different vertical facial bone patterns. The patients in low angle group have more options for the implantation sites, while the patients in high angle group are more prone to maxillary sinus perforation.Therefore, when placing dental implants and designing orthodontic treatment plans in this area, the vertical facial bone pattern should be taken into consideration. [ABSTRACT FROM AUTHOR]

Novel oil-soluble fluorescent carbon quantum dots (o-CDs) are prepared by pyrolysis with citric acid， glutathione and oleamine as raw materials. The o-CDs have good photochemical properties and optical stability. The maximum excitation wavelength and emission wavelengths are located at 375 and 440 nm， respectively， and the fluorescence quantum yield is 0. 48. A fluorescence sensor with high sensitivity and selectivity for detection of oxytetracycline is established based on the fluorescence quenching effect. The o-CDs based fluorescence sensor exhibits a good linear relationship between the relative fluorescence intensity and the concentration of oxytetracycline (0. 77~16. 12 µg/mL) with the detection limit of 0. 14 µg/mL. Furthermore， the sensor has the potential to determine oxytetracycline in milk samples. The spiked recoveries are in the range of 97. 13%~104. 18%， and the RSD value is less than 5%. The accuracy of the method is verified. The o-CDs is capable of monitoring oxytetracycline in food industry. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the efficacy and safety of Escitalopram oxalate tablets combined with Quetiapine fumarate tablets in treatment of depression. METHODS: 100 patients with depression admitted into Jinzhou Kangning Hospital from Oct. 2013 to Oct. 2015 were selected to be divided into observation group and control group via the random number table,with 50 cases in each. The control group were treated with Escitalopram oxalate tablets, while the observation group received Escitalopram oxalate tablets combined with Quetiapine fumarate tablets. The efficacy and adverse drug reactions of two groups were observed. RESULTS: The total effective rate of observation group was 84. 0% (42/50), significantly higher than that of control group [54. 0% (27/50) ], with statistically significant difference (P < 0. 05). After treatment of 2 weeks, 4 weeks and 8 weeks, the HAMD score of two group of patients were significantly lower than those of before treatment,with statistically significant difference (P < 0. 05); while there was no difference between two groups (P > 0. 05). The incidence of adverse drug reactions in observation group and control group were respectively 12. 0% (6/50) and 14. 0% (7/50), without any statistically significant difference (P < 0. 05). CONCLUSIONS: The effects of Escitalopram oxalate tablets combined with Quetiapine fumarate tablets in treatment of depression is effective,with few adverse drug reactions and high safety. [ABSTRACT FROM AUTHOR]

To investigate the effect of recycled tyre polymer fiber (RTPF) on the drying shrinkage properties of concrete， dry shrinkage tests and analysis of the mechanism of fiber action were carried out on plain concrete， RTPF (volume fraction is 0.1%， 0.2%， 0.4% and 0.8%，respectively) concrete and 0.1%polypropylene fiber (PPF) concrete. Results indicated that the slump of RTPF concrete with different contents decreases by 8.1%~62.2%， and the air fraction increases by 11.2%~47.9% as compared with plain concrete. The drying shrinkage rate of RTPF concrete increases rapidly at 0~7d and then tends to be stabilized. The addition of RTPF reduces the early growth rate of the drying shrinkage of concrete. The drying shrinkage rate of concrete decreases initially and then increases with the increase of RTPF content. When the volume fraction of RTPF is 0.2%， the concrete shows the minimum drying shrinkage rate. The drying shrinkage rates of RTPF concrete with different contents at 7d and 28d are 14.2%~36.0% and 2.9%~27.2%， respectively， which are lower than those of plain concrete. The drying shrinkage rate of PPF concrete is lower than that of RTPF concrete at the same volume fraction (0.1%). In terms of the inhibiting concrete drying shrinkage， RTPF with a volume fraction of 0.2% could replace PPF with a volume fraction of 0.1%. The scanning electron microscope showed that RTPF could bond well with the concrete matrix and transfers the shrinkage stress of the concrete matrix. Finally， by comparing the test data and fitting value of drying shrinkage rate， a drying shrinkage calculation model suitable for RTPF concrete was obtained. [ABSTRACT FROM AUTHOR]

Smart home uses Internet of Things technology to provide users with automatic intelligent services, but the traditional centralized architectures have security problems such as confidentiality and integrity, while the existing distributed architectures have problems such as repeated authentication and high latency. To solve these problems, based on blockchain and elliptic curve integrated encryption technology, this paper proposed a smart home authentication and access control scheme. At the same time, it introduced edge computing to reduce the delay of the system. It also combined the capability based access control with the blockchain, stored the capability token on the blockchain, and designed the corresponding smart contract to achieve secure access control. Security analysis showed that the scheme had the security characteristics of decentralization, tamper proof, confidentiality, integrity and scalability. Simulated experiment was carried out on Ethereum blockchain, and the performance of the scheme was evaluated according to computing overhead, communication overhead and response time. The evaluation results show that compared with other schemes, this scheme has less computational and communication overhead and shorter response time, has obvious advantages. [ABSTRACT FROM AUTHOR]

The results of hydrodynamic model experiment of otter board will have different degree of test deviation due to various factors such as processing method and structure simplification. In order to explore the influence mechanism of the processing materials of the otter board model on the hydrodynamic experiment, the double-slit rectangular curved otter board was selected as the research object. Based on the fluid-structure coupling algorithm combined with the flume tank model experiment, the influence on the hydrodynamic experiment and its structural response difference between the three 3D printing materials otter board and the traditional steel materials otter board was analyzed. The results show that there are significant differences in structural response and hydrodynamic performance between the traditional metal (Steel) and non-metal (ABS) models. With the increase of the angle of attack and the flow rate, the maximum deformation of the otter board increases, and the difference of lift coefficient and drag coefficient also increases. Due to the large elastic modulus and strong rigidity of PVC material, the structural response is close to that of metal material, so it has little influence on the results of hydrodynamic experiment. Based on the above results, PVC can be used as the 3D printing material to ensure the accuracy of the model and reduce the influence of the model material on the accuracy of the hydrodynamic experiment results. [ABSTRACT FROM AUTHOR]

Objective To investigate the long-term safety and effectiveness of withdrawal of hepatitis B immuneglobulin (HBIG) and/or nucleos(t)ide analogues (NAs) to prevent hepatitis B virus (HBV) reinfection in liver transplant recipients with hepatitis B-related diseases after successful vaccination. Methods Baseline data of 76 liver transplant recipients undergoing hepatitis B immune reconstitution after receiving hepatitis B vaccines were retrospectively analyzed. The vaccination and response, the follow-up results of respondents with HBIG and/or NAs withdrawal, and the reinfection of HBV after withdrawal of HBIG and/or NAs were analyzed. Results The time interval from liver transplantation to hepatitis B vaccination was 26 (20, 40) months. The time interval from vaccination to response was 15 (8,27) months. Initially, 76 recipients withdrew HBIG, and 36 recipients withdrew HBIG and NAs. During the follow-up, 12 of 76 recipients who withdrew HBIG resumed use of HBIG, and 16 of 36 recipients who withdrew HBIG and NAs resumed use of NAs. The withdrawal time of HBIG and NAs was 135 (98,150) and 133 (34,149) months, respectively. Sixteen respondents did not receive booster, and 36 respondents received boosters on a regular basis. The time interval between the first booster and HBIG withdrawal was 44 (11,87) months. No significant differences were observed in baseline data between the respondents with and without boosters (all P>0.05). During the follow-up, 9 recipients were lost to follow-up, 5 were re-infected with HBV, 3 died, and 1 recipient developed graft loss and underwent secondary liver transplantation. Among 5 recipients re-infected with HBV, 4 cases had virus mutation. Significant differences were found between re-infected and uninfected patients regarding withdrawal of NAs and hepatitis B e antigen (HBeAg) positive before transplantation (both P<0.05). Conclusions Long-term withdrawal of HBIG is feasible and safe for recipients with successful hepatitis B immune reconstitution after liver transplantation for hepatitis B-related diseases. Nevertheless, whether antiviral drugs can be simultaneously withdrawn remains to be validated. [ABSTRACT FROM AUTHOR]

Objective To observe the expression changes of long non-coding RNA (lncRNA)Zinc finger antisense 1 (ZFAS1) in serum of colon cancer patients and its clinical significance. Methods Totally 102 patients with colon cancer (colon cancer group)and 54 volunteers (control group) were selected. Serum lncRNA ZFAS1 expression was detected by real-time fluorescence quantitative polymerase chain reaction (qRT-PCR). We analyzed the relationship between lncRNA ZFAS1 expression and clinicopathological features and prognosis of colon cancer patients. Results The relative expression of lncRNA ZFAS1 in serum of the colon cancer group was higher than that of the control group (P<0. 01). Expression of lncRNA ZFAS1 was related to the degree of differentiation, T stage and N stage of colon cancer (all P<0. 01). Kaplan-Meier survival curve analysis showed that the 3-year progression-free survival (PFS) and overall survival (OS) of patients with high lncRNA ZFAS1 expression were lower than those with low lncRNA ZFAS1 expression (both P<0. 05). Multivariate Cox proportional risk regression analysis showed that N1- N2 and high expression of lncRNA ZFAS1 were risk factors for poor prognosis of patients with colon cancer (both P<0. 01). Conclusions The expression of lncRNA ZFAS1 in serum increases in patients with colon cancer. The expression of lncRNA ZFAS1 is related to the degree of differentiation, T stage, N stage and prognosis of colon cancer, and can be used as a potential marker for prognosis evaluation of colon cancer. [ABSTRACT FROM AUTHOR]

目的了解上海审医疗机狗药学人员配置现状和队伍结构, 为优化上海市药学人员合理配置、提离药学 服务水平提供参考。方法采用自行设计的"2020年上海市医疗机构药学人员信息调查表", 由上海市16个区的医 院（含辖区内的市级医院）和社区卫生服务中心在调查表（电子版）中填报本机构内药学人员的数据信息。结果 2020年上海市10 635名药学人员中超过70%分布在医院, 其中近50%在三级医院, 社区卫生服务中心药学人员 数量最少。中心城区医疗机构药学人员数量最多的为5 352人（50.32%）,远郊地区医疗机构药学人员数量最少的 为1 695人（15.94%）。药学人员的平均年龄为（37.6±9.31）岁, 30~39岁人员占49.61%。医疗机构药学人员的职 称汉初、中级职称为主, 近50%的药学人员是调剂药师, 有近30%的药学人员文化程度为大专及以下, 远郊区脸 床药师占比最高。结论 上海市医疗机构药学人员多集中在二、三级医院, 基层药学力量较为薄弱;区域分布较 为不均衡, 临床药师整体数量不足, 药学人员专业能力还有待提升. [ABSTRACT FROM AUTHOR]

The accurate prediction of tensile strain capacity (TSC) is the key to the strain-based design and assessment of buried pipelines. Various TSC prediction models were proposed by research institutions such as the Pipeline Research Council International and the Center for Reliable Energy Systems were not applicable to the pipelines with corrosion defects. In view of this, a new TSC prediction model for corroded pipes was proposed based on the extensive parametric finite element analysis validated by full-size pipe tensile tests. In the proposed model, a defect geometry factor function was constructed to describe the effect of defect depth, width, and length on strain capacity based on the correlation between the TSC and the influence parameters. The accuracy and reliability of the proposed model were verified by the nonlinear regression analysis and the error analysis. The results show that the average prediction error of the proposed model is 5. 78% compared to the finite element results. Compared with the experimental test results, the minimum and maximum prediction errors of the proposed model are 3. 68% and 24. 51%, respectively. The predicted range of the proposed model can meet the needs of the actual safety assessment of the corrosion pipelines in the strain-design lot. [ABSTRACT FROM AUTHOR]

The hydrodynamic model experiment results of trawling otter board often have different degrees of deviation due to various experimental factors such as Reynolds number and model scale ratio. To understand the Influence mechanism in the hydrodynamic model experiment of otter board, this paper selects vertical cambered V-Type otter board as the research object, bases on the flume tank model experiment combined with computational fluid dynamics (CFD) numerical simulation method, the hydrodynamic performance and flow field distribution were compared and analyzed, aims to explore the influence of model scale ratio, board thickness and model material on its hydrodynamic performance experiment. The results show that the change of model scale ratio has no significant effect on the curve shape of lift coefficient and drag coefficient, but excessive reduction of model scale ratio (20 ∶1) will lead to significant deviation of lift coefficient at the small angle of attack ( α < 30°). The change of the board thickness will lead to a significant change of the lift coefficient at the large angle of attack (α> 30°), while the influence on the drag coefficient mainly reflects on the small angle of attack ( α < 30°). Non-metallic material model is insufficient rigidity, and it is easy to produce certain displacement and deformation after obtaining stress in the flume tank model experiment process, which will cause the deviation of experimental results. Based on the above results, the model scale should be as large as possible to reduce the influence of model scale on the accuracy of experimental results. The structure stability of the model can be improved by increasing the board thickness, but the thickening range should not be more than double of the prototype. [ABSTRACT FROM AUTHOR]

As one of the typical geological hazard, landslide seriously threatens the safe operation of buried pipelines. If the limit landslide displacement that the pipeline can bear can be accurately predicted, the pipeline failure accident can be effectively predicted combined with advanced landslide monitoring technology. In view of this, firstly, a pipe-soil interaction model with nonlinear contact was established and verified. Then, the effects of model parameters and boundary conditions on simulation results were discussed. Finally, the prediction method of the limit landslide displacement for stress/ strain criterion is researched. The conclusions are as follows. The nonlinear contact pipe-soil interaction model with infinite boundaries on both sides is more suitable for the mechanical response analysis of pipeline under real landslide conditions. Using this model, the large deformation and separation of pipeline and soil can be effective simulated by that model, the limit landslide displacement based on stress and strain criteria can also be predicted. This paper provides an effective technical means for the safety design of pipelines in mountainous areas and the prevention and control of landslide accidents. [ABSTRACT FROM AUTHOR]

Objective To observe the safety and clinical effect of the application of levosimendanin to advanced aged patients with acute decompensated chronic heart failure. Method 45 acute decompensated chronic heart failure patients more than 85 years old with low cardiac output （Cardiac function ：Ⅲ-Ⅳ level ，left ventricular ejective fraction≤40%and high blood plasma NT-ProBNP≥500 ug/L），experimental group （23 cases） were given levosimendan treatment， and control group （22 cases） were given dobutamine treatment. Vital signs， general clinical status，LVEF， and blood plasma NT-ProBNP changes were monitored before and after drug use. Results No statistical difference between the two groups was observed before treatment（ P＞0.05） . At different time points after treatment， compared with the control group， the experimental group were statistically significant （ P＜0.05 orP ＜0.01） in relieving clinical status of heart failure， raising LVEF and reducing blood plasma NT-ProBNP.Incidence of adverse reactions is 22.7%in the experimental group and 42.9% in the control group， no serious adverse reactions in either group. Conclusion Levosimendan can improve heart failure symptoms， raise heart function level in advanced aged patients with acute decompensated chronic heart failure. It is safe and effective with no serious adverse reactions. [ABSTRACT FROM AUTHOR]

A nitrogen sulfur co-doped fluorescent carbon dot（N，S-CDs）is synthesized by pyrolysis from citric acid and glutathione as starting materials. The morphology and properties of synthesized N，S-CDs are characterized by transition electron microscopy（TEM），UV-Vis absorption，fluorescence spectroscopy，and X-ray photoelectron spectroscopy（XPS）. The N，S-CDs has an average particle size of（2. 55 ± 0. 75）nm， and is also highly fluorescent at about 440 nm with excitation at 360 nm，respectively，and a relative fluorescence quantum yield as 0. 46. The presence of oxytetracycline can effectively quench the fluorescence of N，S-CDs with a good selectivity. The N，S-CDs is applied for the detection of oxytetracycline in milk，and the linear relationship is found in the range of 0. 77~18. 40 μg/mL，with the detection limit as 0. 09 μg/mL. And the regression equation is y=0. 02282x+0. 02913. The preparation is straightforward and the detection of oxytetracycline is also less complicated. [ABSTRACT FROM AUTHOR]

Graphene quantum dots（GODs）are a kind of novel carbon-based zero-dimensional materials, which can be regarded as extremely small graphene fragments. GQDs possess unique 2D structure，quantum confinement effect and edge effect，which is similar to graphene materials. GQDs have many advantages, such as unique photoluminescence property，low toxicity，high fluorescent stability and high biocompatibility, which result in extensive applications of GQDs，including detection，sensing，catalysis，cellular-imaging, drug delivery and pollution control. The synthesis methods of GQDs could be divided into top-down and bottom-up. The mechanism of the top-down method is cutting large-size materials like graphene，graphite and carbon materials into smaller sizes to obtain GQDs，while the mechanism of the bottom-up method is synthesizing GQDs using different precursors through the hydrothermal method or pyrolysis. Citric acid（CA） is a kind of the most popular precursors used in synthesis of GQDs through the bottom-up method. In the recent years，lots of research related to synthesis of GQDs by using CA as precursors are published. In this study，many CA-based synthesis methods of heterogeneous GQDs and their applications are introduced. [ABSTRACT FROM AUTHOR]

Ice and snow disasters are the main factors affecting the efficiency of road transportation and the safety of life and property in our country. The salt storage anti-icing pavement technology that actively solves this problem is widely used, but there are few studies on long-term evaluation. The ice-interface bonding force of the salt storage anticoagulant ice asphalt mixture was investigated from the mechanical perspective, and the critical effective chloride ion concentration of the ice removal performance failure of the salt storage anticoagulant ice asphalt mixture was proposed. Through the whole simulation vehicle load and environment under the condition of rainfall release characteristic of chlorine ion, chlorine ion was tested by ISE single release concentration and cumulative release concentration, according to determine the critical concentration of available chlorine ion release effective salt effective cycle of asphalt mixture, and the failure of the regenerative asphalt mixture of salt slice processing, the actual release depth of chlorine ion in the mixture. Finally, the simulated precipitation in the test box was converted into the annual average precipitation in different regions of the country, and the actual service life of salt storage and anti-freezing ice asphalt pavement was estimated. The results show that the critical effective chloride ion concentration is 0. 000 9 mol/ L at the test temperature. Under the full simulation state, the effective action period of salt storage asphalt mixture is 45 cycles, and the effective action depth of chloride ion in the mixture is about 2 cm. The effective total rainfall of snow melting and ice suppression for anti-condensing ice asphalt pavement is 2 245. 5 mL. According to the ratio of the effective total rainfall to the annual rainfall in different regions, the effective action period of snow melting and ice suppression for anticondensing ice pavement is 1. 79 ~3. 72 years. [ABSTRACT FROM AUTHOR]

Objective To screen the pathogenic mutations in the four generations of a proband with atrial septal defect, so as to analyze the relationship between genotype and phenotype by whole exon sequencing and Sanger sequencing. Methods Retrospectic analysis of the clinical data on a child with atrial septal defects treated in the Department of Cardiovascular Surgery, the First People’s Hospital of Yunnan Province was conducted in tandem with genetic tests for the sick child, his younger brother and mother by means of whole-exome sequencing to find out the genetic causes of the family in combination with bioinformatics analysis. Meanwhile, sporadic ASD patients and healthy people were screened for the Caudal Homebox Gene 4 (CDX4) mutation found in the family. Results The cardiac ultrasound results of the sick child and the intraoperative findings conformed with ASD diagnosis. The genetic tests suggested that CDX4 gene c.C233T homozygous mutation occurred to the child, his mother carries heterozygous mutation of the gene and his younger brother homozygous mutation of it. Codon 233 of exon 1 of CDX4 gene mutated from C to T (c.C233T), leading to conversion of amino acid 78 from proline to leucine ( p.P78L). Multi-species comparison showed that the locus was highly conserved. The three software programs PROVEAN, Mutation Taster and Mutation Assessor suggested that the mutation was harmful. Of the 198 patients with sporadic atrial septal defects, 5 suffered this gene mutation, but that was not found in the 265 healthy people. According to the Fischer’s Exact Test, CDX4 gene c.C233T homozygous mutation was associated with congenital heart diseases (P = 0.014). Conclusion CDX4 gene c.C233T (p.P78L） homozygous mutation is the highly likely the pathogenic mutation of the family. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of epidural anesthesia on the coagulation function of patients with pregnancy thrombocytopenia. Methods: 86 patients with pregnancy-induced thrombocytopenia admitted to our hospital from June 2018 to June 2019 were enrolled in the study. According to the random number table method, divided into study group and control group, with 43 cases in each group. The study group was given epidural anesthesia, and the control group was given general anesthesia, the changes of various indicators of maternal coagulation system before and after anesthesia were observed and compared. Results: The APTT of the study group before the anesthesia, at 0.5 h after anesthesia, at 0.5 h, 24 h, and 48 h after surgery were longer than those of the control group (PO.OS). The average blood loss and the average blood loss after 24 hours were significantly lower in the study group that in the control group (P<0.05). There was no significant difference in the Apgar scores between the two groups at 1 min and 5 min (P>0.0 5) . Conclusions: Epidural anesthesia has little effect on the coagulation function of pregnant women with thrombocytopenia, but the anesthesia has a fast onset and effective effect, and can reduce the amount of surgery and postoperative bleeding to some extent. [ABSTRACT FROM AUTHOR]

In order to ensure the successful smooth implementation of cultivated land fallow project and long-term preservation of its effectiveness, China has been developing reasonable subsidy policy of cultivated land fallow in recent years. Excessive agricultural intensification and chemical agricultural production has caused a series of problems in China, such as soil productivity deterioration pressure, soil pollution, soil degradation etc.. These problems restrict the farmland sustainable use and agricultural sustainable development. At the same time, the overall supply of China's grain is relatively abundant, and there is a phenomenon of price inversion in the international grain market. Farmland fallow refers to the measures taken by land owners or users to replace crops or not to farm in a certain period for the purpose of improving farming efficiency and promote sustainable use of land. It is important to select some area as a pilot area in China, and implement cultivated land fallow project, because this not only can maintain the sustainable development, the restoration of soil fertility, and improve the quality of cultivated land, but also can balance the grain supply and demand contradiction to ensure food security and stable income of farmers. In this article, we selected the United States, Japan, the European Union, China Taiwan and other countries and regions as the study areas. It is mainly because these areas have many years of experience in fallow practice, and have developed the policy of subsidy to the farmers. The agricultural development in the United States and the European Union have a large scale farm, which is characterized by large scale of operation, high degree of mechanization and professional farmers. But the characteristics of farm in Japan and China are small both in size and economic scale, which is known for low mechanization, high specialization of agricultural management, and scattered farmers. In this paper, we reviewed the literature and used comparative analysis and induction to analyze the practice of fallow subsidy in these countries and regions, then summarized the purpose of the fallow subsidy, the model of implementation, the form of subsidies (the basis of subsidy and the fund of subsidy). In addition, China has practiced a pilot project in fallow of cultivating arable land for one year. During that time, there are a few areas in fallowing, they are mainly in the areas of groundwater funnel, heavy metal pollution, serious ecological degradation, continuous cropping and other ecological environment. Overall, the cultivated land fallow system pilot area has achieved good results, food production capacity has improved, ecological environment has also been improved. However, since the fallow system in China is only in the exploratory stage, the implementation of the fallow subsidy policy may also have many potential problems, including the insufficient motivation of compensation subject, the lack of flexibility in the subsidy standard, the single source of subsidy funds and the weakness of subsidy systems. Finally, in view of these problems in the subsidy policy of cultivated land fallow in China, in this paper, we put forward some suggestions on how to improve the subsidy policy in the future, those include developing dynamic goals, maximizing the subsidy benefit, making different types of subsidy, and diversifying the source of funds. According to the principle of differentiation and diversification, we also attempted to construct the conceived framework of China's fallow subsidy policy in order to provide reference for the establishment of the subsidy policy framework of cultivated land fallowing in China. [ABSTRACT FROM AUTHOR]

Objective To explore the relationship between acute exacerbation of chronic obstructive pulmonary disease （AECOPD） and pulmonary hypertension （PH） in patients with chronic obstructive pulmonary disease （COPD） . Methods Using retrospective analysis，we collected from March 2015 to March 2016 in the department of respiratory internal medicine （ward two） in our hospital， 38 cases of AECOPD combined with pulmonary hypertension patients as a experimental group， 46 cases of simple AECOPD patients in the same period as the control group. And we collected basic data. The serum of Interleukin- 6 （IL- 6）， Procalcitonin （PCT）， High sensitive C reactive protein （hs- CRP）， N- Terminal pro- Brain natriuretic peptide （NT- proBNP） were collected after admission within 24 hours， the results of Chest CT and Ultrasonic echocardiography. Compared with the control group and experimental group of two groups in the above indicators. Results AECOPD combined with PH group of the smoking index， hs- CRP， PCT， NT- proBNP were higher than the simple AECOPD group （P＜ 0.05），and had positive correlation with pulmonary artery systolic pressure （P＜0.05） . Logistic regression analysis showed that NT- proBNP was an independent risk factor for pulmonary arterial hypertension （OR=1.89，P＜0.01） . Clolusions Smoking and serum hs- CRP， PCT， NT- proBNP are positively correlated with elevated pulmonary artery pressure，NT- proBNP is an independent risk factor for pulmonary arterial hypertension. Smoking and systemic inflammation are involved in the formation of pulmonary hypertension in COPD. [ABSTRACT FROM AUTHOR]

Objective To establish retroperitoneal orthotopic renal transplantation model in Diannan small-eared swine. Methods Ten pairs of Diannan small-eared swines， which with the same ABO blood type ， the negative of cross matching and complement-dependent cytotoxicity (CDC) cross reaction were performed with retroperitoneal orthotopic renal transplantation， end-to-end anastomosis method was implemented between the donor's and the receptor's renal artery，vein and ureter. Results One case appeared renal vein thrombosis，1 case appeared acute renal tubular necrosis， both resulted in the dysfunction of transplanted kidney， 8 cases of postoperative graft function gradually returned to normal. No complications such as severe hemorrhage，infection， ureteral obstruction， urinary leakage ， intestinal obstruction happened， the graft survival rate was 80%. Conclusions Swine retroperitoneal orthotopic renal transplantation model is stable and reliable， with easier operational procedure， less complications and higher graft survival rate. [ABSTRACT FROM AUTHOR]

A first-principles method based on the density functional theory is used to calculate the formation energies, densities of states, and charge densities of Si and Ga doped diamond/copper composite interface structures in order to study the interface property of diamond/copper composite.The results show that because the lower the formation energy, the more stable the interface structure, the interface models with stable structures are Si doped diamond (100)/copper (111) into interval ІІ, Si doped diamond(111)/copper(111) into the first layer of copper atom, Ga doped diamond (100)/copper (111) into interval І and Ga doped diamond(111)/copper(111) into the first layer of copper atom. Because of the decrease of formation energy in Si and Ga doped diamond/copper composites interfaces, the density of state in Fermi level increases and the chemical bond is formed, the interface models of Si and Ga doped diamond/copper composites are the stable structure. Therefore, the Si and Ga doped is an effective means to improve the interface property of diamond/copper composite. [ABSTRACT FROM AUTHOR]