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Objective The co-cracking technology of ethane and propane is optimized. Methods The BSPA ethylene cracking evaluation test equipment of KBR company is used to optimize the separate cracking of ethane and propane and the blending cracking technology according to different ratios in the laboratory. Results When the blend proportion of ethane is 20 %- 90 %, t he yields of ethylene, diene and triene are increased. When the blend proportion of ethane is 80%-90%, the highest yields of ethylene, diene and triene are 55. 28 %, 56. 05 % and 58. 01 %, respectively. Conclusion T he optimized result is applied in industrial ethylene cracking plant, the total ethylene yield and the diene yield don't decrease when the proportion of light cracking feedst0ck in t he whole cracking feedstock reduced more than 10%, and the remarkable industrial application effect has been obtained. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the potential mechanism of Huazhi Rougan Granules in the treatment of non-alcoholic fatty liver disease(NAFLD) based on network pharmacology and molecular docking. METHODS: The drug compound targets were screened by using the Traditional Chinese Medicine Systematic Pharmacology Database and Analysis Platform and the Encyclopedia of Chinese Medicine database, the disease targets of NAFLD were screened by using the GeneCards database and DigSee database, so that the related networks were constructed. Gene ontology function enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed for the shared targets by using R language. Finally, the molecular docking verification of key compounds and core targets was conducted, and the results were visualized by using Pymol software. RESULTS: The predicted core compounds were quercetin, kaempferol, luteolin and wogonin, the core targets were signal transduction and activating transcription factor 3, JUN, interleukin-6, tumor necrosis factor, CXCL8, vascular endothelial growth factor A, epidermal growth factor, interleukin-1β, chemokine ligand 2 and TP53. The results of KEGG pathway enrichment analysis showed that the pathways were associated with infectious diseases, immune system, endocrine and metabolic diseases, such as the AGE-RAGE signaling pathway, human cytomegalovirus infection and other signaling pathways in diabetic complications. CONCLUSIONS: The results of this study have initially validated and predicted the mechanism of Huazhi Rougan granules in the treatment of NAFLD, which laid a good foundation for further insight into its mechanism of action. [ABSTRACT FROM AUTHOR]

Septic shock is a common acute and critical disease in the emergency department. It refers to the persistent hypotension caused by severe infection, and the acute circulatory failure that is difficult to correct after adequate fluid resuscitation, which can quickly lead to severe damage of tissues and organs. The main cause of death is multi-organ failure, with a higher fatality rate. Anisodamine, an anticholinergic drug extracted from Chinese Solanaceae, can dilate the blood vessels, improve the microcirculation, improve the cardiovascular function, protect cells and reduce the blood lactic acid concentration, and decrease the mortality of septic shock. It is an important auxiliary means for the treatment of septic shock and is worthy of clinical application. This study systematically collected and reviewed the related literature on the treatment of septic shock with anisodamine by searching the databases of CNKI, Wanfang database and VIP database. The results showed that anisodamine was effective in the treatment of septic shock, and its main anti-shock mechanisms included relieving vasospasm, improving microcirculation, inhibiting platelet aggregation, blocking M-cholinergic receptor, stimulating the respiratory center of the body, regulating the vagus nerve and inhibiting the gland secretion. It is hoped that this review can provide a reference for the clinical application of anisodamine in the treatment of septic shock. [ABSTRACT FROM AUTHOR]

Anisodamine is an anticholinergic drug isolated from the Chinese Solanaceae. It is an M choline receptor blocker and is mainly used in the treatment of septic shock, smooth muscle spasm, peripheral vascular disease(thromboangiitis obliterans, diabetic peripheral vascular disease, etc.), various neuralgia, vertigo and fundus diseases(central retinitis, retinal arterial thrombosis). In this study, the clinical application literature of anisodamine was reviewed and analyzed by systematically searching databases such as CNKI, Wanfang database and VIP database. The results showed that anisodamine was mainly used for septic shock, smooth muscle spasm, vertigo, acute pancreatitis, calculous renal colic and bronchial asthma; in the meantime, anisodamine was also used in diabetic foot, gestational hypertension, anesthesia and endoscopy. It is hoped that this study can provide reference for the clinical application and further study of anisodamine. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To tentatively investigate the mechanism of Ruyi Zhenbao tablets in treatment of stroke. METHODS: Protein-protein interaction (PPI) network related to stroke was constructed, and targets related to 112 active chemical components from Ruyi Zhenbao tablets were predicted. Active ingredients-predieted targets network of Ruyi Zhenbao tablets was established, active ingredients-potential targets network of Ruyi Zhenbao tablets related to stroke was established, enrichment analysis of gene ontology (GO) was performed, and the enrichment analysis of the biological pathways of Kyoto encyclopedia of genes and genomes (KEGG) was conducted to study the mechanism of Ruyi Zhenbao tablets in treatment of stroke. RESULTS: The active ingredients-potential targets network of Ruyi Zhenbao tablets related to stroke contained 29 targets, and the key targets were inducible nitric oxide synthase, endothelial nitric oxide synthase, phosphatidyl Inositol-4, 5-diphosphate 3-kinase catalytic subunit, sodium channel protein type 5 alpha subunit, transcription factor AP-1, Gaspase-3, estrogen receptor Body, etc. In GO enrichment analysis, there were 12 GO terms, mainly including protein binding, enzyme binding and positive regulation of transcription Irom RNA polymerase II promoter. There were 13 KEGG pathways, mainly involved in tumor signaling pathways, focal adhesions and proteoglycans in tumors. CONCLUSIONS: The findings preliminarily verify and predict the basic pharmacological ellects and relevant mechanisms of Ruyi Zhenbao tablets in treatment of stroke,which lay a solid foundation for further studies on the mechanism of Ruyi Zhenbao Tablets in the treatment of stroke. [ABSTRACT FROM AUTHOR]

Objective The aim is to analyze the optimal allocation of domestic ethylene cracking feedstock, and provide relevant information and technical reference for refining and chemical enterprises. Methods After rational analysis of the investment heat of ethylene production from ethane cracking, it was pointed out that the feedstock of ethylene production from steam cracking in China was still mainly naphtha with a small amount of low-carbon hydrocarbon and low-octane oil. The important roles of naphtha separation technology and cracking evaluation test in the optimization of ethylene feedstock were described. The physical properties and cracking properties of coal-based naphtha and petroleum-based cracking feedstock were compared and analyzed. Results The hot investment of the cracking of ethane to ethylene should be cautious and rational, while actively activating naphtha resources, the by-products such as low-carbon hydrocarbons and low-octane oil products, which were suitable for ethylene cracking feedstock, should be selected and used reasonably. The mass fraction of N-alkanes in coal-based naphtha was 72.83%, and the yields of ethylene, propylene, diene and triene were 18.33%-26.27%, 5.92%-12.34%, 16.50%-21.41%, 12.66%-17.53% higher than those of petroleum-based naphtha, respectively. The ethylene yield of coal-based naphtha was 10.95% and 10.74% higher than that of topped oil and light hydrocarbon of oil field, respectively. The yield of diene was 4.28% and 4.09% higher than that of topped oil and light hydrocarbon of oil field respectively. The yield of triene was 6.89% higher than that of topped oil and 6.22% higher than that of light hydrocarbon. Conclusions Based on the actual domestic energy structure of rich coal, poor oil and lack gas, the superiority of refining and chemical integration to be brought into full play, and the cracking feedstock of petroleum-based ethylene to be brought into active play, taking coal-based naphtha as a breakthrough to develop new sources of cracking feedstock was an effective way to solve the problem of shortage of domestic ethylene cracking feedstock, to improve the quality and efficiency of refining and chemical plants, to promote the high-quality development of refining and chemical industry, and to ensure energy security and realize the sustainable development of ethylene industry. [ABSTRACT FROM AUTHOR]

Objective The aim is to analyze the optimal allocation of domestic ethylene cracking feedstock, and provide relevant information and technical reference for refining and chemical enterprises. Methods After rational analysis of the investment heat of ethylene production from ethane cracking, it was pointed out that the feedstock of ethylene production from steam cracking in China was still mainly naphtha with a small amount of low-carbon hydrocarbon and low-octane oil. The important roles of naphtha separation technology and cracking evaluation test in the optimization of ethylene feedstock were described. The physical properties and cracking properties of coal-based naphtha and petroleum-based cracking feedstock were compared and analyzed. Results The hot investment of the cracking of ethane to ethylene should be cautious and rational, while actively activating naphtha resources, the by-products such as low-carbon hydrocarbons and low-octane oil products, which were suitable for ethylene cracking feedstock, should be selected and used reasonably. The mass fraction of N-alkanes in coal-based naphtha was 72.83%, and the yields of ethylene, propylene, diene and triene were 18.33%-26.27%, 5.92%-12.34%, 16.50%-21.41%, 12.66%-17.53% higher than those of petroleum-based naphtha, respectively. The ethylene yield of coal-based naphtha was 10.95% and 10.74% higher than that of topped oil and light hydrocarbon of oil field, respectively. The yield of diene was 4.28% and 4.09% higher than that of topped oil and light hydrocarbon of oil field respectively. The yield of triene was 6.89% higher than that of topped oil and 6.22% higher than that of light hydrocarbon. Conclusions Based on the actual domestic energy structure of rich coal, poor oil and lack gas, the superiority of refining and chemical integration to be brought into full play, and the cracking feedstock of petroleum-based ethylene to be brought into active play, taking coal-based naphtha as a breakthrough to develop new sources of cracking feedstock was an effective way to solve the problem of shortage of domestic ethylene cracking feedstock, to improve the quality and efficiency of refining and chemical plants, to promote the high-quality development of refining and chemical industry, and to ensure energy security and realize the sustainable development of ethylene industry. [ABSTRACT FROM AUTHOR]

Objectives The on-line sampling device for cracking gas in ethylene cracking furnace was developed, and an on-line sampling device for cracking gas was obtained with compact structure, sufficient gas-liquid separation, and small sampling and analysis error, which can improve the accuracy of cracking gas analysis. Methods After analyzing the shortcomings of the existing cracking gas sampling devices, it is determined that the newly developed sampling device should have the advantages of full- component sampling, sufficient gas-liquid separation, small sampling and analysis errors, compact structure, easy movement, and convenient assembly and maintenance. It is an on-line sampling device for cracking gas with two-step condensation, sufficient gas- liquid separation, and real and reliable analysis data. Results The volume of the condensing shell I and cryogenic shell II of the formed cracking gas on-line sampling device are not less than 140 L and 130 L, respectively, the produced cracked gas flow rate is 15-25 L/min, and the produced cracking gas outlet temperature is not more than 550 °C, under the above conditions, the temperature of the gas-phase material after gas-liquid separation is not higher than 25 °C, which can realize the full-component sampling of the cracking gas, and the gas-liquid separation is sufficient. Conclusions After sampling and analysis of the developed cracking gas on-line sampling device, the water-oil ratio of the cracking furnace deduced is 0. 498, which is very close to the actual operation water-oil ratio of 0. 50, indicating that the sampling method and data processing algorithm used by the cracking gas online sampling device have high performance scientific rationality. The industrial cracking furnace was calibrated by using the on-line sampling device of cracking gas, and the calibration data were used to guide the optimization and control of the outlet temperature (COT) of industrial cracking furnace. With the gradual increase of COT from 845 °C to 855 °C, the yield of propylene and butadiene did not change much, but the ethylene yield increased from 27. 78% to 30. 31%, with an increase of 2. 53 percentage points, and the effect was remarkable. In general, the yield of diene and triene decreased slightly at first and then increased with the increase of outlet temperature of cracking furnace, the increase range reached 5. 83% and 5. 42%, respectively, which effectively improved the efficiency of the plant. [ABSTRACT FROM AUTHOR]

目的 探讨两组种根管封闭剂AH-Plus、iRoot SP根尖封闭性能的差异。方法将80颗离体单根管牙以Protaper镍钛机用锉冠向下法根管预备至F2，随机分为A、B、C 、D组，每组20颗。 A、B组分别使用AH-Plus、iRoot SP根管封闭剂以热牙胶连续波垂直加压技术进行根管充填，C组使用iRoot SP根管封闭剂以单尖法进行根管充填，D组不做任何充填。用染料渗入法和透明牙法对标本进行处理后，测量染料渗入根管的长度。结果 A、B、C、D组染料渗入长度分别为（0．81±0．27）、（0．75±0．23）、（0．97±0．12）、（11．32±0．45）mm。 A、B、C 组染料渗入长度与D组比较差异有统计学意义（ P均＜0．05）；A、B、C 三组比较染料渗入长度差异无统计学意义（ P＞0．05）。结论 根管封闭剂iRoot SP的根尖封闭性能与 AH-Plus相似，单尖法根管充填iRoot SP的根尖封闭性能有待进一步研究。 [ABSTRACT FROM AUTHOR]

Objective In order to improve the operational efficiency of ethylene cracking unit, a fast and efficient technical solution for the optimized operation of ethylene cracking furnaces was provided. Methods The on-site calibration test plan for ethylene cracking furnace was established, the physical properties and composition of cracking raw materials were analyzed. Taking naphtha cracking furnace and hydrogenation tail oil (HTO) cracking furnace as examples, self-developed online sampling devices were utilized to conduct on-site calibration tests for guiding the optimization and adjustment of cracking furnace outlet temperature (COT) for ethylene cracking furnace. Results The calibration test showed that the optimal COTs for the naphtha cracking furnace and the HTO cracking furnace were 855 ℃ and 830 ℃, respectively. Under the above control temperatures, the yield of diene (ethylene+propylene) and trienee (ethylene+propylene+1,3-butadiene) in the naphtha cracking furnace reached the highest values of 45.53% and 49.15%, respectively. The yield of diene and triene in the HTO cracking furnace reached the highest values of 52.10% and 59.21%, respectively. A significant improvement in yield was obtained. Conclusions An independently developed online sampling device was used, and the calibration test plan described in this paper was implemented. At production capacity of 800×10³ t/a ethylene cracking unit, on-site calibration tests were conducted on different raw material cracking furnaces to optimize the cracking process, which could effectively improve the yield of cracking target products and achieve the goal of improving the operational efficiency of the ethylene cracking unit. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To explore the mechanism of Jinteng Qingbi granules in the treatment of gout based on network pharmacology and molecular docking technology. METHODS: Active components and effect targets were collected through Traditional Chinese Medicines Systems Pharmacology Platform and literature retrieval. Disease genes related to gout were retrieved by DisGeNET and GeneCards database. Drug-component-predicted target network, gout related protein-protein interaction network, drug-component-target-pathway network were constructed by Cytoscape 3. 9. 0. Gene Ontology (GO) function enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed for potential targets by using R software R Studio. Pathway Builder Tool software was used to draw the partial pathway diagram. Autodock software was used to conduct molecular docking on the screened key components and core targets. RESULTS: A total of 153 active components and 873 predicted targets were screened from 11 drugs of Jinteng Qingbi granules, and 148 potential targets of gout were selected. GO enrichment analysis involved 2 378 biological processes, 118 cell components and 159 molecular functions, with a total of 2 655 entries. Totally 162 pathways including cancer pathway, C-type lectin receptor signaling pathway, phosphatidylinositol 3 kinase-protein kinase B signaling pathway, tumor necrosis factor signaling pathway and Toll-like receptor signaling pathway were obtained by KEGG pathway enrichment analysis. Molecular docking results showed that the binding energy between key components and related targets was low and the affinity was considerable. CONCLUSIONS: The study verifies and predicts that active components of Jinteng Qingbi granules can achieve the treatment efficacy of gout by acting on multiple targets and regulating multiple pathways, and provides ideas for the study of mechanism and clinical application. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To systematically review the clinical efficacy and safety of Aidi injection combined with taxotere + cisplatin (TP) chemotherapy in the treatment of non-small cell lung cancer (NSCLC). METHODS: CNKI, VIP, CBM, Wanfang Data, PubMed and the Cochrane Library were retrieved ( the search time was from database establishment to Jan. 15th, 2023) to collect the clinical randomized controlled trials ( RCT) of Aidi injection combined with TP chemotherapy in the treatment of NSCLC ( the control group was treated with TP chemotherapy, while the research group received Aidi injection on the basis of the control group). Relevant data were extracted and Meta-analysis was performed by using RevMan 5. 4 and Stata software. RESULTS: Totally 16 articles were enrolled, including 1 131 patients (570 cases in the research group and 561 cases in the control group). Results showed that the effective rate of research group was significantly higher than that of the control group (RR = 1. 42,95%CI = 1. 26-1. 61, P<0. 000 01), and the Kanofsky performance score was significantly higher than that of the control group (RR = 1. 76, 95%CI = 1. 52-2. 04,P<0. 000 01), the differences were statistically significant. In terms of adverse reactions, the incidence of leukopenia, thrombocytopenia, erythrocytopenia, gastrointestinal reactions and liver injury in the research group was lower than that in the control group, with statistically significant difference (P<0. 05). CONCLUSIONS: Aidi injection combined with TP chemotherapy in the treatment of NSCLC can significantly improve the overall efficacy, improve the quality of life, and reduce adverse drug reactions in patients. However, the randomized controlled trials on which the conclusions of this study are based cannot confirm whether the requirements such as double blindness are strictly implemented, and more research is needed to confirm them. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the mechanism of Qihuang Tongmi soft capsules in the treatment of constipation through network pharmacology and molecular docking. METHODS: Based on Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and TCM Database@ Taiwan and other databases, the chemical components and its targets of the 11 traditional Chinese medicines in Qihuang Tongmi soft capsules were retrieved, the component-target network was constructed, the constipation-related targets were retrieved through DrugBank, GeneCards and other databases, the protein-protein interaction (PPI) network was constructed by STRING database, the Gene Ontology (GO) functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis on key targets were conducted by using DAVID database, the results visualization was performed by using R language, the key chemical components and core targets were imported into the AutoDockTools 1. 5. 7 software to calculate its binding energy and molecular docking. RESULTS: A total of 124 chemical components and 113 disease targets were screened out, the quercetin and kaempferol were the key components in the network; the top 3 proteins ranked by degree value in the PPI network were protein kinase B1, tumor protein p53 and epidermal growth factor receptor, respectively. The GO functional enrichment analysis showed that, of the 102 entries, 55 were related to biological processes, 31 were related to molecular functions, and 16 were related to cellular components. KEGG pathways enrichment analysis showed that 115 pathways were mainly concentrated on endocrine drug-resistance and mitogen-activated protein kinase signaling pathways; all the binding energy of molecular docking were < - 20. 92 kJ/ mol. CONCLUSIONS: This research reveals partial mechanism of Qihuang Tongmi soft capsules in the treatment of constipation, which provides references for the in-depth development of clinical research and application of Qihuang Tongmi soft capsules [ABSTRACT FROM AUTHOR]

OBJECTIVE: To analyze the active components and mechanism of Danbai granules in the treatment of pelvic inflammatory diseases. METHODS: CNKI, PubMed, traditional Chinese medicine systems pharmacology database and analysis platform, GeneCards and other databases were retrieved to collect the corresponding targets and related targets of pelvic inflammatory disease. The intersection of chemical component targets and disease targets was analyzed using STRING database. The above analysis results were based on Cytoscape to construct the compositiontarget map and protein-protein interaction network map of Danbai granules. Cytoscape was used to draw the composition-target map and protein-protein interaction network map of Danbai granules. The gene ontology ( GO) function enrichment analysis and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis were performed for intersection targets by using R language. The molecular docking was verified by AutoDockTools software. RESULTS: Totally 70 compounds and 377 compound targets, 240 compound and disease intersection targets in Danbai granules were obtained by screening. According to relevant parameters, the key targets of Phosphatidylinositol-3-kinase catalytic subunit alpha isoform (PIK3CA), sarcoma gene (SRC), tumor protein 53 (TP53), heat shock protein 90α (HSP90AA), protein kinase B1 (Akt1), mitogen activated protein kinase 3 (MAPK3), MAPK1, estrogen receptor 1(ESR1), epidermal growth factor receptor (EGFR), tumor necrosis factor α (TNF-α), v-rel reticuloendotheliosis viral oncogene homolog A (RELA) and interleukin 6 (IL-6) further screened. Enrichment analysis showed that 186 KEGG pathways and 3 730 GO functional items were obtained. GO function entries contained 3 324 items related to biological processes, 166 items related to cell components, and 240 items related to molecular functions. Results of molecular docking verification showed that quercetin, luteolin, kaempferol, naringenin and other compounds had strong binding ability with SRC, TP53, HSP90AA, Akt1, MAPK1, ESR1, EGFR, TNF-α and IL-6. CONCLUSIONS: Danbai granules may act on key target genes such as TNF-α, IL-6 and EGFR through NF-κB signaling pathway, MAPK signaling pathway, and PI3K-Akt signaling pathway to play its role in the treatment of pelvic inflammatory disease. [ABSTRACT FROM AUTHOR]

To probe into the active ingredients and possible mechanism of Jinteng Qingbi granules in the treatment of rheumatoid arthritis. METHODS: The chemical ingredients and rheumatoid arthritis-related targets in Jinteng Qingbi granules were obtained through traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP), DisGeNET, GeneCards and other databases. Intersection targets of the two were imported into the STRING database for analysis, and the results were imported into Cytoscape software to draw the protein interaction ( PPI) network map, the ingredients target network map of Jinteng Qingbi granules, and the drug-ingredient-target-pathway network map. Gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed on key targets by R software. Active ingredients in Jinteng Qingbi granules and the corresponding key targets were verified by molecular docking using AutoDockTools software. RESULTS: There were 153 compounds, 399 compound-related targets and 131 intersection targets in Jinteng Qingbi granules. Key targets such as protein kinase B1 (Akt1), cystatin protease 3 ( CASP3), epidermal growth factor receptor ( EGFR), interleukin 6 ( IL-6), sarcoma gene ( SRC), estrogen receptor 1 ( ESR1), hypoxia-inducible factor 1 (HIF1), and amino-terminal protein kinase ( JUN) were screened according to network topology parameters. PPI network analysis yielded 151 KEGG pathways and 2 567 GO functional entries. Totally 2 294 items related to biological process, 119 items related to cellular component and 154 items related to molecular function were included in the GO items. Molecular docking results showed that quercetin, luteolin, beta-sitosterol, 3, 8- dihydroxyquinoline, paeoniflorin and other compounds had good binding activity to Akt1, CASP3, EGFR, IL-6, SRC, ESR1, HIF1 and JUN. CONCLUSIONS: Jinteng Qingbi granules in the treatment of rheumatoid arthritis is based on the multi-component and multi-target mechanism of action. This study provides a theoretical basis for the next step to verify the relevant mechanism. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the potential active components and possible mechanism of Mailuo Shutong pills in the treatment of hemorrhoids. METHODS: Chemical constituents of Mailuo Shutong pills and the related targets of hemorrhoids were obtained by Traditional Chinese medicine systems pharmacology database and analysis platform, DisGeNET, GeneCards and other databases. The intersection targets were imported into STRING database for analysis, and the analysis results were imported into Cytoscape software to construct protein-protein interaction (PPI) network diagram, Mailuo Shutong pills chemical components-target network diagram and drug-component-target-pathway network. The key targets were analyzed by gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Gene and Genome (KEGG) pathway enrichment analysis by R language. AutoDockTools software was used to verify the molecular docking between the active components of Mailuo Shutong pills and the corresponding key targets. RESULTS: A total of 215 compounds, 310 related targets, and 148 compound and disease intersection targets were screened. Key targets including protein kinase B (Akt) 1, tumor protein p53 (TP53), interleukin (IL) 6, epidermal growth factor receptor (EGFR), vascular endothelial growth factor A (VEGFA), ESR1, HIF1A and tumor necrosis factor (TNF) were identified. Based on the analysis of PPI network, there were 161 KEGG pathways and 3 041 GO functional entries were obtained. In the GO functional items, there were 2 706 biological process related items, 140 cellular components, and 195 molecular function related items. The results of molecular docking showed that quercetin, formononetin, luteolin, wogonin, kaempferol and other compounds had good binding activity with Akt1, TNF, TP53, IL-6, EGFR, VEGFA and ESR1. CONCLUSIONS: Mailuo Shutong pills in the treatment of hemorrhoids is based on the mechanism of multi-components and multi-targets. This study provides theoretical basis for further verification of related mechanisms. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To explore the mechanism of Jingfang granules in the treatment of influenza based on network pharmacology and molecular docking technology. METHODS: The components and targets of Jingfang granules were investigated by traditional Chinese medicine systems pharmacology database and analysis platform（ TCMSP）.GeneCards database was used to retrieve the targets of influenza,and the potential targets of Jingfang granules in the treatment of influenza were obtained. Protein-protein interaction（ PPI） network analysis was performed on the potential targets through the STRING database. Gene ontology（ GO） and Kyoto encyclopedia of genes and genomes（ KEGG）enrichment analysis of potential targets were performed by R software RStudio． “Drug-component-potential targets” network was constructed by using Cytoscape 3. 7. 2. Autodock was used to carry out the molecular docking of important active components and key targets. RESULTS: A total of 159 components that met the screening criteria（ OB≥30%,DL≥0. 18） of Jingfang granules were retrieved, and 2 574 targets for influenza were collected, and 54 targets were obtained as potential targets for the treatment of influenza with Jingfang granules by taking the intersection. GO and KEGG enrichment analysis showed that Jingfang Granule played an essential role in the treatment of influenza mainly through acting on influenza A signaling pathway, MAPK signaling pathway, TNF signaling pathway. Quercetin, luteolin, beta-sitosterol, kaempferol, naringin and wogonin were important effective components of Jingfang granules in the treatment of influenza. PTGS2,PRSS1,ADRB2,MAPK14 and RELA were key targets in the treatment of influenza. Through molecular docking, it was found that quercetin, luteolin, beta-sitosterol, kaempferol and wogonin had low binding energy and good affinity with related targets. CONCLUSIONS: Jingfang granules may inhibit influenza virus and regulate immune response of the body by acting on targets such as PTGS2,PRSS1,ADRB2,MAPK14 and RELA and regulating influenza A signaling pathway, TNF signaling pathway, MAPK signaling pathway and IL-17 signaling pathway. [ABSTRACT FROM AUTHOR]

For the optimum selection and utilization of ethlene pyrolysis materials, the thermal pyrolysis tests of hydrocracked naphtha, coal chemical naphtha, straight run naphtha, diesel hydrogenated naphtha, and coking hydrogenated naphtha were carried out. The pyrolysis yields of ethylene, propylene, butadiene, methane, residual C4 and pyrolysis liquid phase products were compared and analyzed. The results showed that the distribution and yield of pyrolysis products of different kinds of naphtha were very different. For example, coal chemical naphtha and coking hydrogenation naphtha pyrolysis produced more ethylene, the hydrocracked naphtha pyrolysis produced more propylene, the butadiene yields of the straight-run naphtha pyrolysis was up to 6.11%, and the coking hydrogenated naphtha pyrolysis residual C4 yield was as low as 2.73%, diesel hydrogenated naphtha pyrolysis liquid phase product ratio was high. Therefore, combined with pyrolysis product yield, the raw material cost and supply, and the olefin market situation, rational selection of naphtha for pyrolysis and effective use of its pyrolysis liquid product can greatly reduce the ethylene production costs, improve the comprehensive competitiveness of naphtha pyrolysis ethylene. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To tentatively investigate the mechanism of functional material basis and compatibility mechanism of Renqingmangjue capsules in treatment of metabolic disease based on network pharmacology. METHODS: Traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP) was retrieved for the chemical constituents and action targets of 12 traditional Chinese medicines in Renqingmangjue capsules. The therapeutic target database (TTD) was used to retrieve the metabolic disease targets. The compound-target network and target-pathway network were constructed to study the mechanism of Renqingmangjue capsules in treatment of metabolic disease, and finally the possible active components and targets of Renqingmangjue capsules were screened out. RESULTS: A total of 38 potential targets of Renqingmangjue capsules in treatment of metabolic disease were retrieved, including 1 target related to hyperlipidemia (3-hydroxy 3-methvl glutaryl coenzyme A reductase), 1 target related to hyperuricemia (xanthine dehydrogenase), and 36 targets related to diabetes. There were 8 pathways involved, including Chagas disease, Toll-like receptor signaling pathway, tumor necrosis factor signaling pathway, insulin resistance, legion Bacterial disease, nonalcoholic latty liver, T cell receptor signaling pathway and influenza A. CONCLUSIONS: The results of this study preliminarily verify the basic pharmacological action and mechanism of Renqingmangjue capsules in treatment of metabolic disease, which lav a solid foundation for lurther studies on the mechanism of action. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To tentatively investigate the mechanism of Safflower Kuyi pills in treatment of gynecological diseases based on network pharmacology. METHODS: Traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP), traditional Chinese medicine database @ Taiwan (TDT) and CNKI were retrieved for the chemical components, corresponding targets and diseases related to Safflower Kuyi pills. Compound-target network, target-disease network, TCM-compound-target-disease network, protein interaction (PPI) network, and target-pathway network were established to explore the mechanism of Safflower Kuyi pills in treatment of gynecological diseases. RESULTS: The compound-target network included 73 chemical components and 99 targets, the hub targets involved prostaglandin G/H synthase 2(PTGS2), prostaglandin G/H synthase 1 (PTGS1) and heat shock protein HSP 90(HSP90), etc. The PPI network contained 97 proteins, in which the hub proteins involved mitogen-activated protein kinase 1(MAPK1), mitogen-activated protein kinase 8(MAKP8) and tumor protein p53(TP53), etc. Totally 37 GO terms were gene ontology (GO), among them, there were 22 items related to biological processes, 7 items related to molecular function, and 8 items related to cell composition. The Kyoto encyclopedia of genes and genomes (KEGG) pathway contained 14 pathways, including neuroactive ligand-receptor interaction, pathways in cancer, estrogen signaling pathways and calcium signaling pathways, etc. CONCLUSIONS: The results of this study preliminarily elucidate the basic pharmacological action and its mechanism of Safflower Kuyi pills in treatment of gynecological diseases, which lay a solid foundation for further studies on the mechanism of action. [ABSTRACT FROM AUTHOR]

Reducing the ratio of diesel to gasoline is an effective measure for refining chemical companies to meet market demand, improve quality, increase efficiency, and maintain sustainable development. The co-pyrolysis of light diesel oil and heavy vacuum gas oil(HVGO) can be used as one of the important ways to reduce the ratio of diesel to gasoline. The pyrolysis performance tests of light diesel oil and HVGO were performed in a laboratory pyrolysis evaluation device, and the copyrolysis calibration tests of light diesel oil and HVGO with different pyrolysis furnace outlet temperatures and mixing ratios were conducted in the USC industrial pyrolysis furnace. The results showed that the total product yield of low-carbon olefins and C5 & C+ was more than 76%. Comparing with HVGO, the yield of low-carbon olefins which were pyrolyzed by light diesel oil was much lower, while the yield of high value-added pyrolysis C5 & C+ was higher of 10% to 15%. The yields of ethylene, propylene, and triene by co-pyrolysis of light diesel oil mixed with HVGO (2 : 5) were 31.48%, 15.29%, and 53.05% respectively at 835 °C of the pyrolysis furnace outlet temperature. The olefins yield of co-pyrolysis of light diesel oil mixed with HVGO by ratio of 1 : 3 is higher at 841 C. In summary, it is economically reasonable by using co-pyrolysis of light diesel oil and HVGO to reduce the ratio of diesel to gasoline. [ABSTRACT FROM AUTHOR]

The physical properties analysis results show that the content of paraffin in the coal chemical naphtha is high (>90 wt%), the content of naphthenes and aromatics is less, while the content of latent aromatic is low. By comparing the pyrolysis gas/liquid product yield of coal chemical naphtha at 860-900 ℃, it shows that the coal chemical naphtha is a high quality pyrolysis raw material, which is suitable for pyrolysis at high temperature (900 ℃). With the increase of pyrolysis temperature, the pyrolysis liquid phase product yield decreases and the content of aromatics in the pyrolysis liquid phase product increases. The pyrolysis liquid phase product is based on C5-205 ℃ component as the main component (>75 wt%), of which benzene, toluene, xylene together account for more than 70 wt%. Compared with the refinery head oil and naphtha, the price of coal chemical naphtha is low, the output will increase year by year, the yield of pyrolysis ethylene and triene is high and the yield of pyrolysis liquid phase product is slightly lower. Therefore it will be a new path to solve the shortage of ethylene raw materials and enhance the benefits of deep processing of coal resources by taking the coal chemical naphtha to be a reasonable supplement of ethylene enterprise raw material resources. [ABSTRACT FROM AUTHOR]

Period verification of equipment is an important part in national laboratories. The verification is carried out between two calibration, it target is to keep credibility of equipment calibration. The paper researches the aim, object, method and operation effect of the equipment period verification of the Lab of Pressurization Feed System. It provides period verification metliod of comparison and verification which is used frequently in the lab. It also offers judgment basis. The lab gets important effect in equipment management after the period verification runs. Firstly, the change of the equipment state can be discovered in advance, so it offers judgment for taking preventive measure. Secondly, it offers originate judgment for non-qualified equipment, so it ensures correct testing dates. Thirdly, it makes reasonable equipment management procedure, so it conserves management cost. [ABSTRACT FROM AUTHOR]

A series of co-pyrolysis tests of naphtha and methyl cyclohexane were carried out to study the products yield changes in pyrolysis of different proportions and at different temperatures. The result showed that comparing with the naphtha pyrolysis alone, the yield of co-pyrolysis ethylene decreased while the yield of butadiene substantially increased. Relatively high temperatures are benefit for high butadiene yield while smaller drop of ethylene yield. The co-pyrolysis of naphtha and methyl cyclohexane can optimize the pyrolysis gas product distribution and improve the comprehensive added value of products. It can fully rely on existing ethylene pyrolysis unit and subsequent separation system. Meanwhile, co-pyrolysis has the advantages of high feasibility, lower investment and stable operation, which can meet the requirements of industrial production. [ABSTRACT FROM AUTHOR]