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Objective: To investigate the prevalence of peripheral neuropathy (DPN) in community patients with type 2 diabetes mellitus (T2DM) in Yangpu District of Shanghai, and to analyze its influencing factors. Methods: From March 2019 to March 2020, five communities were randomly selected from the communities under the jurisdiction of Yangpu District, Shanghai. 100 patients with T2DM were selected from each community by stratified random sampling. The prevalence of DPN in patients with T2DM was counted, and the influencing factors of DPN were analyzed by multivariate logistic regression. Results: Univariate analysis results showed that there were differences between DPN group and non DPN group in waistline, combined diabetic retinopathy (DR), combined peripheral vascular disease (PVD), smoking history, hypertension, history of cerebral infarction, education level, marital status, systolic blood pressure (SBP), fasting blood glucose (FPG), time in range (TIR), apolipoprotein B and lithic acid (P<0.05). Further multivariate logistic regression analysis showed that combined DR, combined PVD, have a history of smoking, have a history of cerebral infarction, unmarried/divorced/widowed marital status and higher FPG level were the risk factors of DPN in T2DM patients (P<0.05). Conclusions: The prevalence of DPN is high in patients with T2DM, combined with DR, PVD, smoking history, cerebral infarction history and marital status are the influencing factors of DPN, we should pay attention to DPN screening and intervention, and carry out health education for T2DM patients according to the above influencing factors to reduce the occurrence of DPN. [ABSTRACT FROM AUTHOR]