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Your search keyword '"Wiesmann, Marion"' showing total 2 results
Start Over Author "Wiesmann, Marion" Topic vascular endothelial growth factor (vegf) Database Academic Search Index
2 results on '"Wiesmann, Marion"'

1. Design and structure–activity relationship of 3-benzimidazol-2-yl-1H-indazoles as inhibitors of receptor tyrosine kinases

Author

McBride, Christopher M., Renhowe, Paul A., Heise, Carla, Jansen, Johanna M., Lapointe, Gena, Ma, Sylvia, Piñeda, Ramon, Vora, Jayesh, Wiesmann, Marion, and Shafer, Cynthia M.

Subjects
*GROWTH factors, *CYTOKINES, *PEPTIDES, *TYROSINE
Abstract

Abstract: 3-Benzimidazol-2-yl-1H-indazole analogs were developed as inhibitors of receptor tyrosine kinases (RTK). The synthesis and SAR of this series is reported. [Copyright &y& Elsevier]

Published
2006
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2. Design and structure–activity relationship of heterocyclic analogs of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones as inhibitors of receptor tyrosine kinases

Author

Frazier, Kelly, Jazan, Elisa, McBride, Christopher M., Pecchi, Sabina, Renhowe, Paul A., Shafer, Cynthia M., Taylor, Clarke, Bussiere, Dirksen, He, Molly Min, Jansen, Johanna M., Lapointe, Gena, Ma, Sylvia, Vora, Jayesh, and Wiesmann, Marion

Subjects
*PROTEIN-tyrosine kinase inhibitors, *CHEMICAL inhibitors, *PHARMACOKINETICS, *CHEMICAL kinetics
Abstract

Abstract: Herein are described a series of novel heterocyclic analogs of the 4-amino-3-benzimidazol-2-ylhydroquinolin-2-one scaffold. These compounds are potent inhibitors of receptor tyrosine kinases and exhibit favorable pharmacokinetic profiles. The synthesis and SAR of these compounds are described. [Copyright &y& Elsevier]

Published
2006
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