1. Tertiary lymphoid structures associate with improved survival in early oral tongue cancer.
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Almangush, Alhadi, Bello, Ibrahim O., Elseragy, Amr, Hagström, Jaana, Haglund, Caj, Kowalski, Luiz Paulo, Nieminen, Pentti, Coletta, Ricardo D., Mäkitie, Antti A., Salo, Tuula, and Leivo, Ilmo
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TERTIARY structure , *TONGUE cancer , *ORAL cancer , *OVERALL survival , *SQUAMOUS cell carcinoma , *PROGNOSIS - Abstract
Background: The clinical significance of tertiary lymphoid structures (TLSs) is not well-documented in early oral tongue squamous cell carcinoma (OTSCC).Methods: A total of 310 cases of early (cT1-2N0) OTSCC were included in this multicenter study. Assessment of TLSs was conducted on hematoxylin and eosin-stained sections. TLSs were assessed both in the central part of the tumor and at the invasive front area.Results: The presence of TLSs associated with improved survival of early OTSCC as presented by Kaplan-Meier survival analyses for disease-specific survival (P = 0.01) and overall survival (P = 0.006). In multivariable analyses, which included conventional prognostic factors, the absence of TLSs associated with worse disease-specific survival with a hazard ratio (HR) of 1.96 (95% CI 1.09-3.54; P = 0.025) and poor overall survival (HR 1.66, 95% CI 1.11-2.48; P = 0.014).Conclusion: Histological evaluation of TLSs predicts survival in early OTSCC. TLSs showed superior prognostic power independent of routine WHO grading and TNM staging system. [ABSTRACT FROM AUTHOR]- Published
- 2022
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