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1. Molecular mechanism of HIV-1 resistance to 3′-azido-2′,3′-dideoxyguanosine.

Author

Meteer, Jeffrey D., Schinazi, Raymond F., Mellors, John W., and Sluis-Cremer, Nicolas

Subjects
*MOLECULAR biology, *HIV infections, *THERAPEUTICS, *DEOXYGUANOSINE, *DRUG resistance, *PYROPHOSPHATES, *NUCLEOSIDES
Abstract

Highlights: [•] The mechanism of HIV-1 resistance to 3′-azido-ddG is defined. [•] Kinetic characterization of HIV-1 RT containing L74V, F77L, V106I, L214F, R277K, and K476N. [•] The L74V mutation allows RT to discriminate between dGTP and 3′-azido-ddGTP. [•] K476N partially restored RT’s ability to excise 3′-azido-ddGMP on an RNA/DNA T/P. [Copyright &y& Elsevier]

Published
2014
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