6 results on '"Greenberg, Andrew S."'
Search Results
2. Association of betatrophin with metabolic characteristics in overweight/obese and lean women with PCOS.
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Li, Linxia, Zhang, Feng, Cui, Jingjing, Shi, Yu, Xiang, Jiangdong, Wang, Xuejiao, Zhao, Naisi, Yan, Qingwu, Greenberg, Andrew S., Peng, Yongde, and Ding, Xiaoying
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INSULIN resistance , *POLYCYSTIC ovary syndrome , *HORMONES , *DIABETES , *OBESITY in women , *THIN people - Abstract
As a new hormone, betatrophin has gained attention as a potential new target to combat insulin resistance (IR) and diabetes. Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder among women of the reproductive age with long term sequelae which include IR and metabolic syndrome. The aim of this study is to evaluate the circulating plasma betatrophin levels in overweight/obese or lean women with or without PCOS and also to elucidate possible correlations with anthropometric and metabolic parameters. Thirty-two patients with PCOS as well as fifty-three control subjects were enrolled after obtaining informed written consent. Clinical and biochemical parameters of all subjects were determined. Plasma adiponectin, GLP-1 and betatrophin levels were measured by ELISA. Plasma betatrophin levels were significantly increased in lean patients with PCOS compared with lean and obese controls. Moreover, in PCOS group, betatrophin levels were significantly negatively correlated with waist hip ratio (WHR), fasting insulin level (FINS) and HOMA-IR, whereas, significantly positively correlated with adiponectin level. Multiple regression analysis showed that HOMA-IR was an independent factor influencing serum betatrophin levels. Further follow-up studies are needed to highlight whether and how increased betatrophin secretion play an important role in IR and carbohydrates metabolism in patients with PCOS. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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3. Subcutaneous Adipose Tissue Macrophage Infiltration Is Associated With Hepatic and Visceral Fat Deposition, Hyperinsulinemia, and Stimulation of NF-κB Stress Pathway.
- Author
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Lê, Kim-Anne, Mahurkar, Swapna, Alderete, Tanya L., Hasson, Rebecca E., Adam, Tanja C., Kim, Joon Sung, Beale, Elizabeth, Xie, Chen, Greenberg, Andrew S., Allayee, Hooman, and Goran, Michael I.
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KUPFFER cells , *LIVER cells , *INSULIN resistance , *GENE expression , *ADIPOSE tissues - Abstract
OBJECTIVE--To examine in obese young adults the influence of ethnicity and subcutaneous adipose tissue (SAT) inflammation on hepatic fat fraction (HFF), visceral adipose tissue (VAT) deposition, insulin sensitivity (SI), β-cell function, and SAT gene expression. RESEARCH DESIGN AND METHODS--SAT biopsies were obtained from 36 obese young adults (20 Hispanics, 16 African Americans) to measure crown-like structures (CLS), reflecting SAT inflammation. SAT, VAT, and HFF were measured by magnetic resonance imaging, and SI and β-cell function (disposition index [DI]) were measured by intravenous glucose tolerance test. SAT gene expression was assessed using Illumina microarrays. RESULTS--Participants with CLS in SAT (n = 16) were similar to those without CLS in terms of ethnicity, sex, and total body fat. Individuals with CLS had greater VAT (3.7 ± 1.3 vs. 2.6 ± 1.6 L; P = 0.04), HFF (9.9 ± 7.3 vs. 5.8 ± 4.4%; P = 0.03), tumor necrosis factor-α (20.8 ± 4.8 vs. 16.2 ± 5.8 pg/mL; P = 0.01), fasting insulin (20.9 ± 10.6 vs. 9.7 ± 6.6 mU/mL; P < 0.001) and glucose (94.4 ± 9.3 vs. 86.8 ± 5.3 mg/dL; P = 0.005), and lower DI (1,559 ± 984 vs. 2,024 ± 829 x 10-4 min-1; P = 0.03). Individuals with CLS in SAT exhibited upregulation of matrix metalloproteinase-9 and monocyte antigen CD14 genes, as well as several other genes belonging to the nuclear factor-κB (NF-κB) stress pathway. CONCLUSIONS--Adipose tissue inflammation was equally distributed between sexes and ethnicities. It was associated with partitioning of fat toward VAT and the liver and altered β-cell function, independent of total adiposity. Several genes belonging to the NF-κB stress pathway were upregulated, suggesting stimulation of proinflammatory mediators. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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4. Dietary Blueberry Attenuates Whole-Body Insulin Resistance in High Fat-Fed Mice by Reducing Adipocyte Death and Its Inflammatory Sequelae.
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deFuria, Jason, Bennett, Grace, Strissel, Katherine J., Perfield II, James W., Milbury, Paul E., Greenberg, Andrew S., and Obin, Martin S.
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LABORATORY mice , *FAT cells , *ADIPOSE tissues , *INSULIN resistance , *METABOLIC disorders , *TUMOR necrosis factors , *METALLOENZYMES , *INTERLEUKIN-6 , *CONNECTIVE tissue cells - Abstract
Adipose tissue (AT) inflammation promotes insulin resistance (IR) and other obesity complications. AT inflammation and IR are associated with oxidative stress, adipocyte death, and the scavenging of dead adipocytes by proinflammatory CD11c+ AT macrophages (ATMΦ). We tested the hypothesis that supplementation of an obesitogenic (high-fat) diet with whole blueberry (BB) powder protects against AT inflammation and 18. Male C57BI/6j mice were maintained for 8 wk on 1 of 3 diets: low-fat (10% of energy) diet (LFD), high-fat (60% of energy) diet (HFD) or the HFD containing 4% (wt:wt) whole BB powder (1:1 Vaccinium ashei and V. corymbosum) (HFD+B). BB supplementation (2.7% of total energy) did not affect HFD-associated alterations in energy intake, metabolic rate, body weight, or adiposity. We observed an emerging pattern of gene expression in AT of HFD mice indicating a shift toward global upregulation of inflammatory genes (tumor necrosis factor-α, interleukin-6, monocyte chemoattractant protein 1, inducible nitric oxide synthase), increased M1-polarized ATMΦ (CD11c+), and increased oxidative stress (reduced glutathione peroxidase 31. This shift was attenuated or nonexistent in HFD+B-fed mice. Furthermore, mice fed the HFD+B were protected from IR and hyperglycemia coincident with reductions in adipocyte death. Salutary effects of BR on adipocyte physiology and ATMΦ gene expression may reflect the ability of BB anthocyanins to alter mitogen-activated protein kinase and nuclear factor-κB stress signaling pathways, which regulate cell fate and inflammatory genes. These results suggest that cytoprotective and antiinflammatory actions of dietary BB can provide metabolic benefits to combat obesity-associated pathology. [ABSTRACT FROM AUTHOR]
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- 2009
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5. Adipocyte Death, Adipose Tissue Remodeling, and Obesity Complications.
- Author
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Strissel, Katherine J., Stancheva, Zlatina, Miyoshi, Hideaki, Perfield II, James W., DeFuria, Jason, Jick, Zoe, Greenberg, Andrew S., and Obin, Martin S.
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CELL death , *ADIPOSE tissues , *OBESITY , *FAT cells , *INSULIN resistance , *LIVER , *GENE expression - Abstract
OBJECTIVE--We sought to determine the role of adipocyte death in obesity-induced adipose tissue (AT) inflammation and obesity complications. RESEARCH DESIGN AND METHODS--Male C57BL/6 mice were fed a high-fat diet for 20 weeks to induce obesity. Every 4 weeks, insulin resistance was assessed by intraperitoneal insulin tolerance tests, and epididymal (eAT) and inguinal subcutaneous AT OAT) and livers were harvested for histological, immunohistochemical, and gene expression analyses. RESULTS--Frequency of adipocyte death in eAT increased from <0.1% at baseline to 16% at week 12, coincident with increases in 1) depot weight; 2) AT macrophages (ATMΦPs) expressing F4/80 and CD11c; 3) mRNA for tumor necrosis factor (TNF)-α, monocyte chemotactic protein (MCP)-1, and interleukin (IL)-10; and 4) insulin resistance. ATMΦs in crown-like structures surrounding dead adipocytes expressed TNF-α and IL-6 proteins. Adipocyte number began to decline at week 12. At week 16, adipocyte death reached ∼80%, coincident with maximal expression of CD11c and inflammatory genes, loss (40%) of eAT mass, widespread collagen deposition, and accelerated hepatic macrosteatosis. By week 20, adipocyte number was restored with small adipocytes, coincident with reduced adipocyte death (fourfold), CD11c and MCP-1 gene expression (twofold), and insulin resistance (35%). eAT weight did not increase at week 20 and was inversely correlated with liver weight after week 12 (r = -0. 85, P < 0.001). In iAT, adipocyte death was first detected at week 12 and remained ≤3%. CONCLUSIONS--These results implicate depot-selective adipocyte death and MΦ-mediated AT remodeling in inflammatory and metabolic complications of murine obesity. Diabetes 56: 2910-2918, 2007 [ABSTRACT FROM AUTHOR]
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- 2007
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6. A Low-Glycemic Load Diet Facilitates Greater Weight Loss in Overweight Adults With High Insulin Secretion but Not in Overweight Adults With Low Insulin Secretion in the CALERIE Trial.
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Pittas, Anastassios G., Das, Sai Krupa, Hajduk, Cheryl L., Golden, Julie, Saltzman, Edward, Stark, Paul C., Greenberg, Andrew S., and Roberts, Susan B.
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PULLULANASE , *INSULIN resistance , *INSULIN antibodies , *METABOLIC syndrome , *OVERWEIGHT persons - Abstract
This article discusses research being done on the use of amylopectin starch in promoting the development of insulin resistance. It references a study by S. E. Byrnes et al published in a 1995 issue of the Journal of Nutrition. It compares the effect of a low-glycemic load hypocaloric diet and high-glycemic load diet on healthy overweight men and women.
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- 2005
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