1. Associations of body mass index with glycated albumin and glycated albumin/glycated hemoglobin A1c ratio in Chinese diabetic and non-diabetic populations.
- Author
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He, Xingxing, Mo, Yifei, Ma, Xiaojing, Ying, Lingwen, Zhu, Wei, Wang, Yufei, Bao, Yuqian, and Zhou, Jian
- Subjects
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GLYCOSYLATED hemoglobin , *BODY mass index , *ALBUMINS , *GLUCOSE tolerance tests , *MULTIPLE regression analysis , *ABSOLUTE value - Abstract
Background Recent studies have discussed the relationship between body mass index (BMI) and glycated albumin (GA) level. However, the extent of the influence of BMI on GA remains uncertain. We investigated the associations between BMI and GA, glycated hemoglobin A 1c (HbA 1c ) and GA/HbA 1c , and to analyze the influence of obesity on GA, HbA 1c , and GA/HbA 1c in both Chinese diabetic and non-diabetic populations. Methods A total of 2562 participants, including 1177 men and 1385 women (age 20–80 y), were enrolled. Each subject underwent a 75-g oral glucose tolerance test. Serum GA was detected using a liquid enzyme method, and HbA 1c was assayed using high-performance liquid chromatography. Results In the diabetic patients ( n = 1223), the GA, HbA 1c, and GA/HbA 1c levels were 16.7 ± 3.0%, 6.6 ± .9% (49 ± 9 mmol/mol), and 2.51 ± .33, respectively. In the non-diabetic subjects ( n = 1339), the GA, HbA 1c, and GA/HbA 1c concentrations were 13.8 ± 1.7%, 5.6 ± .4% (38 ± 4 mmol/mol), and 2.47 ± .31, respectively. Decreasing trends in the GA and GA/HbA 1c concentrations and an increasing trend in the HbA 1c concentration (all P for trend <.05) were found to accompany with the increase in BMI, regardless of diabetes status. Multiple regression analysis revealed that BMI was independently related to HbA 1c in the non-diabetic population (standardized β = .158, P < .001); however, the relationship disappeared in the diabetic population ( P > .05). Moreover, in the diabetic and non-diabetic populations, BMI was negatively correlated with GA (standardized β = −.167 and − .231, both P < .001) and GA/HbA 1c (standardized β = −.273 and − .310, both P < .001). Further analysis showed that a 1 kg/m 2 increment in BMI was associated with a .13% decrease in the absolute value of GA. Conclusions In both diabetic and non-diabetic populations, GA and GA/HbA 1c levels are independently and negatively associated with BMI. For every 1 kg/m 2 increment in BMI, the absolute value of GA decreases approximately .13%. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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