1. Role of systemic T-cells and histopathological aspects after subcutaneous implantation of various carbon nanotubes in mice
- Author
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Koyama, Shozo, Endo, Morinobu, Kim, Yoong-Ahm, Hayashi, Takuya, Yanagisawa, Takashi, Osaka, Kazumasa, Koyama, Haruhide, Haniu, Hisao, and Kuroiwa, Naomi
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CARBON , *NANOTUBES , *MAJOR histocompatibility complex , *HLA histocompatibility antigens , *IMMUNOMODULATORS - Abstract
Abstract: We have evaluated the biological responses to four different types of carbon nanotubes (CNTs), by measuring CD4+ and CD8+ T-cells in peripheral blood, and by the histopathological study on tissues surrounding subcutaneously implanted CNTs for up to 3 months. All mice survived, and no large changes in their weights were observed within our experimental period. After 1 week, only single-walled carbon nanotubes (SWNTs) activated major histocompatibility complex (MHC) class I pathway of antigen–antibody response system (higher CD4+/CD8+ value), resulting in the appearance of an edematous aspect. After 2 weeks, significantly high values in CD4+ and CD4+/CD8+ without change in CD8+ signified an activated MHC class II for all samples. It is worth noting that the toxicological response of CNTs was absolutely lower than that of asbestos. As a result, we envisaged that our result (relatively low toxicity of CNTs) will spur the mass-production, as well widespread application of CNTs in the near future. [Copyright &y& Elsevier]
- Published
- 2006
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