1. To Decipher the Mycoplasma hominis Proteins Targeting into the Endoplasmic Reticulum and Their Implications in Prostate Cancer Etiology Using Next-Generation Sequencing Data.
- Author
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Zakariah, Mohammed, Khan, Shahanavaj, Chaudhary, Anis Ahmad, Rolfo, Christian, Ben Ismail, Mohamed Maher, Alotaibi, Yousef Ajami, Zeng, Xiangxiang, Rodríguez-Patón, Alfonso, and Zou, Quan
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PROSTATE cancer , *MYCOPLASMA diseases , *CARCINOGENESIS , *CANCER cells , *DISEASE prevalence - Abstract
Cancer was initially considered a genetic disease. However, recent studies have revealed the connection between bacterial infections and growth of different types of cancer. The enteroinvasive strain of
Mycoplasma hominis alters the normal behavior of host cells that may result in the growth of prostate cancer. The role ofM. hominis in the growth and development of prostate cancer still remains unclear. The infection may regulate several factors that influence prostate cancer growth in susceptible individuals. The aim of this study was to predictM. hominis proteins targeted into the endoplasmic reticulum (ER) of the host cell, and their potential role in the induction of prostate cancer. From the whole proteome ofM. hominis , 19 proteins were predicted to be targeted into the ER of host cells. The results of our study predict that several proteins ofM. hominis may be targeted to the host cell ER, and possibly alter the normal pattern of protein folding. These predicted proteins can modify the normal function of the host cell. Thus, the intercellular infection ofM. hominis in host cells may serve as a potential factor in prostate cancer etiology. [ABSTRACT FROM AUTHOR]- Published
- 2018
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