1. A randomized crossover study to assess the effect of an oat-rich diet on glycaemic control, plasma lipids and postprandial glycaemia, inflammation and oxidative stress in Type 2 diabetes.
- Author
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McGeoch, S. C., Johnstone, A. M., Lobley, G. E., Adamson, J., Hickson, K., Holtrop, G., Fyfe, C., Clark, L. F., Pearson, D. W. M., Abraham, P., Megson, I. L., and MacRury, S. M.
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BLOOD sugar analysis , *TYPE 2 diabetes treatment , *OATS , *TYPE 2 diabetes complications , *ACADEMIC medical centers , *GOVERNMENT agencies , *AGE distribution , *BEHAVIOR modification , *CLINICAL trials , *DIABETES , *DIET , *GLYCOSYLATED hemoglobin , *HEALTH behavior , *INFLAMMATION , *INGESTION , *LIPIDS , *METABOLIC regulation , *TYPE 2 diabetes , *VOLUNTEERS , *DATA analysis , *OXIDATIVE stress , *BODY mass index , *DESCRIPTIVE statistics , *THERAPEUTICS - Abstract
Aims In the UK, lifestyle intervention is first-line management in Type 2 diabetes. It is unclear what type of diet is most efficacious for improving glycaemic control. This study investigated the effects of an oat-enriched diet on glycaemic control, postprandial glycaemia, inflammation and oxidative stress compared with standard dietary advice. Methods In a randomized crossover design, 27 volunteers with Type 2 diabetes, managed on diet and lifestyle only, were observed for two consecutive 8-week periods following either the oat-enriched diet or re-enforced standard dietary advice. Volunteers attended at baseline (habitual intake) and 8 and 16 weeks. Measurements included basic clinical measurements and fasted and postprandial (3-h) glucose and insulin in response to a healthy test meal. Markers of inflammation and oxidative stress, including high-sensitivity C-reactive protein, interleukin 6, interleukin 18, tumour necrosis factor-alpha, adiponectin, thiobarbituric acid reactive substances, oxygen radical antioxidant capacity, oxidized LDL and urinary isoprostanes, were also measured at fasting and in the postprandial period. Results There were no diet-related effects on glycaemic control or glycaemic or insulinaemic responses to the test meal. Total cholesterol (5.1 ± 1.0 vs. 4.9 ± 0.8 mmol/l, P = 0.019) concentrations declined following the oat-enriched diet compared with standard dietary advice. There was a postprandial decline in adiponectin concentration ( P = 0.009), but no effect of dietary intervention. None of the measures of oxidative stress or inflammation were altered by the oat-enriched diet compared with standard dietary advice. Conclusion The oat-enriched diet had a modest impact on lipid lowering, but did not impact on oxidative stress or inflammation in these volunteers with Type 2 diabetes. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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