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The study aimed to measure the impact of the financing structure on the profitability of Jordanian Islamic banks for the period 2010-2019, by using the multiple regression analysis model. The study sample included Jordan Islamic Bank, Safwa Islamic Bank, Islamic International Arab Bank. The independent variables included debt ratio, equity ratio, cash liquidity ratio, bank size, while the dependent variables are return on assets (ROA), return on equity (ROE). The results showed that the financing structure measured by the debt ratio has a positive and statistically significant impact on the profitability of both the Jordan Islamic Bank of Jordan and the Islamic International Arab Bank, while it had a statistically significant negative impact on the profitability of Safwa Islamic Bank, as for the financing structure measured by equity ratio; however, it had a statistically significant positive impact on the profitability of all Jordanian Islamic banks. As for the cash liquidity of bank, it had a statistically significant negative impact on the profitability of Jordanian Islamic banks, while the size of the bank had a statistically significant positive impact on the profitability of Jordanian Islamic banks. [ABSTRACT FROM AUTHOR]