1. Isoquinoline derivatives Zn(II)/Ni(II) complexes: Crystal structures, cytotoxicity, and their action mechanism.
- Author
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Huang, Ke-Bin, Mo, Hui-Yan, Chen, Zhen-Feng, Wei, Jian-Hua, Liu, Yan-Cheng, and Liang, Hong
- Subjects
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QUINOLINE derivatives , *ISOQUINOLINE , *ZINC compounds , *TRANSITION metal complexes , *CRYSTAL structure , *CELL-mediated cytotoxicity , *INHIBITION of cellular proliferation , *APOPTOSIS , *THERAPEUTICS - Abstract
Three transition metal complexes with isoquinoline derivatives: [(MPDQ) 2 Zn(C 2 H 5 OH)ClO 4 ]ClO 4 ( 1 ) (MPDQ = 4,5-methylenedioxy-1-pyridinedihydroisoquinoline), [(PYP) 2 Zn(H 2 O)](ClO 4 ) 2 ( 2 ) (PYP = 5-pyridin-2-yl-[1,3]dioxolo[4,5-g]isoquinoline) and [(MPDQ) 2 Ni(CH 3 OH)ClO 4 ]ClO 4 ( 3 ) were synthesized and fully characterized. All complexes exhibited strong proliferation inhibition activity against various tested cancer cells with high selectivity to tumour and normal cells. BEL-7404 cells were found most sensitive to complex 2 by inducing apoptosis. The process involved the mitochondrial membrane potential depolarization, PARP-proteins cleavage, Bcl-2, p53, p21 expression and caspase family members' activation. Taking these findings into account, it can propose that complex 2 induce cancer cell apoptosis via mitochondrial pathways. The interaction of complex 2 with DNA investigated by fluorescence, CD and viscosity indicated that complex 2 interact with DNA mainly via intercalation. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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