1. Discovery of new selective glucocorticoid receptor agonist leads.
- Author
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Berger, Markus, Rehwinkel, Hartmut, Schmees, Norbert, Schäcke, Heike, Edman, Karl, Wissler, Lisa, Reichel, Andreas, and Jaroch, Stefan
- Subjects
- *
GLUCOCORTICOID receptors , *TETRAHYDRONAPHTHALENE , *AMINO alcohols , *ANTI-inflammatory agents , *IN vitro studies - Abstract
We report on the discovery of two new lead series for the development of glucocorticoid receptor agonists. Firstly, the discovery of tetrahydronaphthalenes led to metabolically stable and dissociated compounds. Their binding mode to the glucocorticoid receptor could be elucidated through an X-ray structure. Closer inspection into the reaction path and analyses of side products revealed a new amino alcohol series also addressing the glucocorticoid receptor and demonstrating strong anti-inflammatory activity in vitro . [ABSTRACT FROM AUTHOR]
- Published
- 2017
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