1. Molecular PET Imaging of Cyclophosphamide Induced Apoptosis with 18F-ML-8.
- Author
-
Yao, Shaobo, Hu, Kongzhen, Tang, Ganghua, Gao, Siyuan, Tang, Caihua, Yao, Baoguo, Nie, Dahong, Sun, Ting, and Jiang, Shende
- Subjects
- *
ADENOCARCINOMA , *CANCER treatment , *ANIMAL experimentation , *APOPTOSIS , *BIOLOGICAL models , *BIOPHYSICS , *DEOXY sugars , *HIGH performance liquid chromatography , *IMMUNOASSAY , *INJECTIONS , *INTRAVENOUS therapy , *RESEARCH methodology , *MICE , *PROBABILITY theory , *RADIOPHARMACEUTICALS , *RESEARCH funding , *STAINS & staining (Microscopy) , *POSITRON emission tomography , *TUMORS , *XENOGRAFTS , *CYCLOPHOSPHAMIDE , *DATA analysis software , *DESCRIPTIVE statistics , *IN vitro studies , *ONE-way analysis of variance - Abstract
In this paper, a novel small-molecular apoptotic PET imaging probe, 18F-ML-8 with a malonate motif structure, is presented and discussed. After study, the small tracer that belongs to a member of ApoSense family is proved to be capable of imaging merely apoptotic regions in the CTX treated tumor-bearing mice. The experimental result is further confirmed by in vitro cell binding assays and TUNEL staining assay. As a result, 18F-ML-8 could be used for noninvasive visualization of apoptosis induced by antitumor chemotherapy. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF