1. Macronutrient Intake-Associated FGF21 Genotype Modifies Effects of Weight-Loss Diets on 2-Year Changes of Central Adiposity and Body Composition: The POUNDS Lost Trial.
- Author
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Heianza, Yoriko, Wenjie Ma, Tao Huang, Tiange Wang, Yan Zheng, Smith, Steven R., Bray, George A., Sacks, Frank M., Lu Qi, Ma, Wenjie, Huang, Tao, Wang, Tiange, Zheng, Yan, and Qi, Lu
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GENOTYPES , *WEIGHT loss , *OBESITY , *BODY composition , *DIET , *ADIPOSE tissues , *ALLELES , *HUMAN body composition , *DIET therapy , *CARBOHYDRATE content of food , *FAT content of food , *GENETIC polymorphisms , *GROWTH factors , *INGESTION , *LOW-fat diet , *REDUCING diets , *RESEARCH funding , *STATISTICAL sampling , *RANDOMIZED controlled trials , *TREATMENT effectiveness , *WAIST circumference , *SEQUENCE analysis - Abstract
Objective: Fibroblast growth factor 21 (FGF21) is involved in the regulation of energy balance and adipose metabolism. Our previous genome-wide association study identified genetic variants in the FGF21 region associated with macronutrient intake preference. We investigated whether the FGF21 genotype modified effects of weight-loss diets varying in macronutrient intake on changes in adiposity in a 2-year randomized diet intervention trial.Research Design and Methods: We genotyped FGF21 rs838147 in 715 overweight or obese individuals who were assigned to one of four diets varying in macronutrient contents. A DEXA scan was performed to evaluate body composition.Results: We observed a significant interaction between the FGF21 genotype and carbohydrate/fat intake on 2-year changes in waist circumference (WC), percentage of total fat mass, and percentage of trunk fat (P = 0.049, P = 0.001, and P = 0.003 for interaction, respectively). In response to the low-carbohydrate/high-fat diet, carrying the carbohydrate intake-decreasing C allele of rs838147 was marginally associated with less reduction in WC (P = 0.08) and significantly associated with less reduction of total fat mass (P = 0.01) and trunk fat (P = 0.02). Opposite genetic associations with these outcomes were observed among the high-carbohydrate/low-fat diet group; carrying the C allele was associated with a greater reduction of WC, total body fat mass, and trunk fat.Conclusions: Our data suggest that FGF21 genotypes may interact with dietary carbohydrate/fat intake on changes in central adiposity and body fat composition. A low-calorie, high-carbohydrate/low-fat diet was beneficial for overweight or obese individuals carrying the carbohydrate intake-decreasing allele of the FGF21 variant to improve body composition and abdominal obesity. [ABSTRACT FROM AUTHOR]- Published
- 2016
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