1. Molecular imaging of lymphoid organs and immune activation by positron emission tomography with a new [18F]-labeled 2′-deoxycytidine analog.
- Author
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Radu, Caius G., Shu, Chengyi J., Nair-Gill, Evan, Shelly, Stephanie M., Barrio, Jorge R., Satyamurthy, Nagichettiar, Phelps, Michael E., and Witte, Owen N.
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POSITRON emission tomography , *IMMUNODIAGNOSIS , *IMMUNOLOGIC diseases , *IMMUNE response , *CANCER , *DISEASES , *LYMPHATICS , *DEOXYRIBONUCLEOTIDES , *THERAPEUTICS - Abstract
Monitoring immune function with molecular imaging could have a considerable impact on the diagnosis and treatment evaluation of immunological disorders and therapeutic immune responses. Positron emission tomography (PET) is a molecular imaging modality with applications in cancer and other diseases. PET studies of immune function have been limited by a lack of specialized probes. We identified [18F]FAC (1-(2′-deoxy-2′-[18F]fluoroarabinofuranosyl) cytosine) by differential screening as a new PET probe for the deoxyribonucleotide salvage pathway. [18F]FAC enabled visualization of lymphoid organs and was sensitive to localized immune activation in a mouse model of antitumor immunity. [18F]FAC microPET also detected early changes in lymphoid mass in systemic autoimmunity and allowed evaluation of immunosuppressive therapy. These data support the use of [18F]FAC PET for immune monitoring and suggest a wide range of clinical applications in immune disorders and in certain types of cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2008
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