1. Intelligent controlled release of sodium thioglycolate in poloxamer-cationic surfactant temperature-sensitive hydrogels.
- Author
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Lei, Yue, Zhou, Yue, Li, Yuheng, Liu, Yue, Gao, Haiyan, Lin, LiangLiang, and Xu, Hujun
- Subjects
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THIOGLYCOLIC acid , *HYDROGELS , *SODIUM , *CATIONIC surfactants , *SURFACE active agents , *GELATION - Abstract
This study aimed to develop a temperature-sensitive perm agent that can reduce the risk of the active ingredient sodium thioglycolate (TGA(Na) in the perm agent to humans. We found that the loading of TGA(Na) in the pure poloxamer formulation reduces its gelation temperature and allows it to gel at room temperature, so we added cationic surfactants to increase its gelation temperature. The temperature-sensitive perm agent was prepared by adjusting the ratio of additives to the desired temperature, and it remained liquid below 32 °C and solidified on contact with the scalp (32 °C). The release behavior of sodium thioglycolate was studied by in vitro release studies and rheology, and the perm performance was investigated. The results showed that its perm efficiency was comparable to that of conventional perm agents, but its sodium thioglycolate transdermal volume was much lower than that of conventional perm agents, with a reduction of nearly 62 %. These results suggest the potential of the temperature-sensitive perm as a healthier alternative for perm design products. [Display omitted] [ABSTRACT FROM AUTHOR]
- Published
- 2023
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