Search

Your search keyword '"STATISTICS"' showing total 2 results
2 results on '"STATISTICS"'

1. The Combined Extract of Zingiber officinale and Zea mays (Purple Color) Improves Neuropathy, Oxidative Stress, and Axon Density in Streptozotocin Induced Diabetic Rats.

Author

Jintanaporn Wattanathorn, Paphaphat Thiraphatthanavong, Supaporn Muchimapura, Wipawee Thukhammee, Kamol Lertrat, and Bhalang Suriharn

Subjects
*BLOOD sugar analysis, *DIABETIC neuropathies, *ENZYME metabolism, *ALTERNATIVE medicine, *ANIMAL experimentation, *BIOPHYSICS, *COMBINATION drug therapy, *CORN, *DOSE-effect relationship in pharmacology, *GINGER, *HISTOLOGICAL techniques, *HYPOGLYCEMIC agents, *MATHEMATICS, *RESEARCH methodology, *MEDICINAL plants, *NERVE tissue, *NEURAL conduction, *ORAL drug administration, *PROBABILITY theory, *RATS, *RESEARCH funding, *SCIATIC nerve, *SEEDS, *STATISTICS, *SUPEROXIDE dismutase, *MALONDIALDEHYDE, *PLANT extracts, *DATA analysis, *OXIDATIVE stress, *DATA analysis software, *DESCRIPTIVE statistics, *PAIN threshold, *ONE-way analysis of variance, *PHARMACODYNAMICS, *PHYSIOLOGY, *PREVENTION
Abstract

Based on the protective effect of the combined extract of purple waxy corn and ginger (PWCG) on oxidative stress related disorders in diabetic condition, we aimed to determine the effect of PWCG on the functional, biochemical, and structural change of the lesion nerve in streptozotocin- (STZ-) diabetic rats. PWCG at doses of 100, 200, and 300 mg⋅kg-1 BW were orally given to STZ-diabetic rats which were subjected to chronic constriction (CCI) at right sciatic nerve for 21 days. The blood sugar was assessed before and at the end of study whereas the sciatic function index (SFI), paw withdrawal threshold intensity (PWTI), and paw withdrawal latency (PWL) were assessed every 3 days until the end of study At the end of study, the determination of nerve conduction velocity (NCV), axon density, oxidative stress status, and aldose reductase (AR) activity of the lesion nerve were performed. It was found that PWCG improved SFI, PWTI, PWL, and NCV together with the improved oxidative stress status and the axon density in the lesion nerve. No changes of AR activity or blood sugar level were observed. Therefore, PWCG might improve the functional and structural changes in STZ-diabetic rats plus CCI via the improved oxidative stress status. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

2. Purple Rice Berry Is Neuroprotective and Enhances Cognition in a Rat Model of Alzheimer's Disease.

Author

Wanassanun Pannangrong, Jintanaporn Wattanathorn, Supaporn Muchimapura, Somsak Tiamkao, and Terdthai Tong-un

Subjects
*ALZHEIMER'S disease prevention, *ALTERNATIVE medicine, *ANALYSIS of variance, *ANIMAL experimentation, *BEHAVIOR, *BIOLOGICAL assay, *BIOPHYSICS, *ENZYMES, *HISTOLOGICAL techniques, *LEARNING, *RESEARCH methodology, *MEDICINAL plants, *LIPID peroxidation (Biology), *MEMORY, *RATS, *RESEARCH funding, *RICE, *STAINS & staining (Microscopy), *STATISTICS, *FUNCTIONAL foods, *PLANT extracts, *DATA analysis, *STATISTICAL significance
Abstract

AbstractAlzheimer's disease, a neurodegenerative disease characterized by progressive memory loss and cognitive impairment, is the most common type of dementia in aging populations due to severe loss of cholinergic neurons in a specific area. Oxidative stress is known to be involved in the pathogenesis of this condition. Therefore, the cognition-enhancing and neuroprotective effects of rice berry (Oryza sativa), a purple-pigmented rice that is rich in antioxidant substances, was evaluated. Young adult male Wistar rats, weighing 180–220 g, were orally given rice berry once daily at doses of 180, 360, and 720 mg/kg of body weight for a period of 2 weeks before and 1 week after the induction of memory deficit and cholinergic lesions with AF64A, a specific cholinotoxin, via bilateral intracerebroventricular administration. One week following AF64A administration the rats were evaluated for spatial memory, neuron density, acetylcholinesterase activity, and hippocampal lipid peroxidation products. Our results showed that rice berry could significantly prevent memory impairment and hippocampal neurodegeneration in hippocampus. Moreover, it also decreased hippocampal acetylcholinesterase activity and lipid peroxidation product formation. These results suggest that rice berry has potential as an effective agent for neurodegeneration and memory impairment in Alzheimer's disease. [ABSTRACT FROM AUTHOR]

Published
2011

Catalog

Books, media, physical & digital resources
See catalog results