1. Selective intrathecal enrichment of G1m1-positive B cells in multiple sclerosis.
- Author
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Lossius, Andreas, Tomescu‐Baciu, Alina, Holmøy, Trygve, Vedeler, Christian A., Røsjø, Egil, Lorentzen, Åslaug R., Casetta, Ilaria, and Vartdal, Frode
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IMMUNOGLOBULIN G , *MULTIPLE sclerosis risk factors , *DISEASE susceptibility , *IMMUNOGLOBULIN allotypes , *B cells - Abstract
Immunoglobulin gamma (IgG) heavy chain genes are associated with susceptibility to multiple sclerosis ( MS) and IgG levels in the cerebrospinal fluid ( CSF). However, how these variants are implicated in disease mechanisms remains unknown. Here, we show that proliferating plasmablasts expressing the G1m1 allotype of IgG1 are selectively enriched in CSF of G1m1/G1m3 heterozygous MS patients, whereas plasmablasts expressing either G1m1 or G1m3 are evenly distributed in blood. Moreover, there was a preferential intrathecal synthesis of oligoclonal IgG1 of the G1m1 allotype in heterozygous patients, whereas controls with Lyme neuroborreliosis displayed oligoclonal IgG1 of both allotypes. This points to a disease-specific mechanism involved in B-cell establishment within the central nervous system in MS. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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