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The paper uses the Poverty Analysis Macroeconomic Simulator (PAMS), a World Bank framework and updates its interface with the Cameroon government macroeconomic framework to analyze the potential impact of the implementation of the HIPC initiative on poverty alleviation. According to the main findings, it is very likely that Cameroon would succeed in achieving the poverty Millennium Development Goal. However, this result would be feasible if and only if the Poverty Reduction Strategy Paper (PRSP) is fully implemented. That is not very certain because of the failure already observed during the first year of PRSP implementation. [ABSTRACT FROM AUTHOR]