1. Neurocognitive and behavioural profile in Panayiotopoulos syndrome.
- Author
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Fonseca Wald, Eric L A, Debeij‐Van Hall, Mariette H J A, De Jong, Eline, Aldenkamp, Albert P, Vermeulen, R Jeroen, Vles, Johan S H, Klinkenberg, Sylvia, Hendriksen, Jos G M, and Debeij-Van Hall, Mariette H J A
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VERBAL memory , *ACADEMIC underachievement , *MENTAL arithmetic , *SYNDROMES , *EPILEPSY & psychology , *COGNITION disorders , *RESEARCH , *EPILEPSY , *RESEARCH methodology , *RETROSPECTIVE studies , *EVALUATION research , *MEDICAL cooperation , *NEUROPSYCHOLOGICAL tests , *COMPARATIVE studies , *RESEARCH funding , *EDUCATIONAL attainment , *PSYCHOLOGICAL factors , *DISEASE complications - Abstract
Aim: To determine neurocognitive performance and behavioural problems in children with Panayiotopoulos syndrome.Method: All 18 children (10 females, 8 males; mean age 4y 7mo; SD 1y 10mo) diagnosed with Panayiotopoulos syndrome at the Kempenhaeghe Epilepsy Center in the Netherlands between 2010 and 2017 were analysed retrospectively. All underwent a neuropsychological/behavioural assessment, an academic assessment, and a 24-hour electroencephalogram.Results: Mean full-scale IQ (93.5; range 76-123; p=0.04) and performance IQ (93.2; range 76-126; p=0.04) were within the normal range, although significantly lower compared to the normative mean. Verbal IQ (96.3; range 76-118) and processing speed (96.1; range 74-114) were not significantly lower. Simple auditory/visual reaction times, visual attention, visual-motor integration, and verbal memory were significantly lower compared to normative values. On average, patients with Panayiotopoulos syndrome were 8 months behind in arithmetic speed and 11 months behind in reading speed for the number of months in school. Behavioural questionnaires revealed significantly higher scores on reported internalizing behavioural problems.Interpretation: Children with Panayiotopoulos syndrome demonstrated diffuse cognitive dysfunction in full-scale IQ, performance IQ, visual attention, visual-motor integration, and verbal memory. A high incidence of internalizing behavioural problems was reported. This strongly suggests neuropsychological and behavioural comorbidity in children with Panayiotopoulos syndrome.What This Paper Adds: Children with Panayiotopoulos syndrome are at risk for cognitive deficits in various cognitive domains. Children with Panayiotopoulos syndrome are also prone to internalizing behavioural problems. Mild-to-severe academic underachievement was present in more than half of the children with Panayiotopoulos syndrome. [ABSTRACT FROM AUTHOR]- Published
- 2020
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