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As the number of college students infected with the human immunodeficiency virus (HIV) has increased significantly in China, the risk of occupational exposure to HIV among healthcare workers (HCW) in college campus clinics has also increased. Our study aimed to evaluate the awareness of HCWs in terms of preventing occupational HIV exposure in college campus clinics compared with HCWs in tertiary hospitals. This cross-sectional study was conducted in nine provinces in China from September to October 2019 (10 college campus clinics, 7 tertiary hospitals). The study's response rate was recorded to be at 87.62% (184 of 210). The knowledge score of HIV among all HCWs was determined to be generally low (67.17 ± 11.17 points), and that of college campus clinics and tertiary hospitals showed no significant difference (66.36 ± 10.36 vs. 67.63 ± 11.61 points, P=0.463). Overall, HCWs in both college campus clinics and tertiary hospitals showed inadequate knowledge regarding occupational HIV exposure. Training for the prevention of occupational HIV exposure should be strengthened in both medical institutions. [ABSTRACT FROM AUTHOR]

Macropinocytosis is a normal cellular process by which cells internalize extracellular fluids and nutrients from their environment and is one strategy that Ras-transformed pancreatic cancer cells use to increase uptake of amino acids to meet the needs of rapid growth. Paradoxically, in non-Ras transformed medulloblastoma brain tumors, we have shown that expression and activation of the receptor tyrosine kinase TrkA overactivates macropinocytosis, resulting in the catastrophic disintegration of the cell membrane and in tumor cell death. The molecular basis of this uncontrolled form of macropinocytosis has not been previously understood. Here, we demonstrate that the overactivation of macropinocytosis is caused by the simultaneous activation of two TrkA-mediated pathways: (i) inhibition of RhoB via phosphorylation at Ser185 by casein kinase 1, which relieves actin stress fibers, and (ii) FRS2-scaffolded Src and H-Ras activation of RhoA, which stimulate actin reorganization and the formation of lamellipodia. Since catastrophic macropinocytosis results in brain tumor cell death, improved understanding of the mechanisms involved will facilitate future efforts to reprogram tumors, even those resistant to apoptosis, to die. [ABSTRACT FROM AUTHOR]

A series of annual natural runoff recorded at eight hydrological stations in the Yellow River basin (YRB) and distributed at the main channel and two sub-basins (Weihe basin and Fenhe basin) are studied during the period from 1951 to 1998. The trends and the beginning points (or abrupt changes) of these series are detected with Mann-Kendall test (M-K test) and its progressive application. The results show that there are similar trends for different stations. The annual natural runoff series, except for stations of Lanzhou, Hekouzhen, and Longmen, have a downward tendency at some stations whose beginning points of the trend or abrupt changes occurred in the early or mid 1990s. However, their initial years of decrease are different. The decreasing trend of runoff has led to drying-up in lower reaches of the YRB, a water resources scarcity crisis, and a deterioration of the ecosystem. The reasons for the trends have been analyzed in this paper The trends of precipitation in the corresponding regions are similar to those of annual natural runoff It is an important aspect for runoff decrease. In addition, human activities have changed the hydrological cycle and lead to a reduction in runoff to a certain degree. Finally, two countermeasures for the runoff decrease are put forward. One is to develop water savings in irrigation regions, and the other is to plan South-to-North water transfer projects for the YRB. However the conflict between supply and demand will still exist for a long time because of the water scarcity in the future. [ABSTRACT FROM AUTHOR]