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Introduction: Technology that enables the orthopaedic surgeon to deliver a surgical plan with precision and reproducibility continues to evolve. Robotic TKA represents the next phase of technological development in knee arthroplasty. Multiple propriety robotic platforms are now available for use in TKA, and one such system is the OMNIBotics platform. We conducted a review of this system, reporting its history and principles of use, published outcomes and our own personal experience performing OMNI robotic-assisted TKAs. Materials and methods: A literature review was conducted using the PRISMA guidelines. Thirteen papers were included for the final review. Results: The OMNIBot is an accurate and consistent delivery tool in TKA surgery and compares favourably to instrumented, navigation-assisted and patient-specific cutting guides. The OMNIBot has been shown to be a reliable tool for delivering different alignment philosophies as well as planning and achieving tibio-femoral coronal balancing. The utility of the system is increased when the robot is used in conjunction with a soft-tissue tensioning device—the BalanceBot. Data regarding PROM's are limited, however results to date show reliable outcomes. Survival analysis of RATKA using the OMNIBot is limited to one study which reported 99.26% survivorship at 3 years. We report our own outcomes using the OMNIBot, having performed 766 TKA's using the OMNIBot, since 2014 with 99.48% survivorship at 6 year follow-up. Conclusion: The OMNIBot platform is an imageless, passive robotic system available since 2007, with over 30,000 TKA's being performed with its assistance. It has a small physical footprint, is relatively inexpensive and time efficient. Our review demonstrates a high level of precision of the surgical planning, with a modestly improved accuracy compared to conventional and navigation technology. Published outcomes are limited, however demonstrate good short-term PROM's and survivorship data that compare favourably to other robotic TKA cohorts. [ABSTRACT FROM AUTHOR]

Correction to: Robotic-assisted total knee arthroplasty with the OMNIBot platform: a review of the principles of use and outcomes Correction to: Archives of Orthopaedic and Trauma Surgery https://doi.org/10.1007/s00402-021-... The original version of this article unfortunately contained a mistake. The original article can be found online at https://doi.org/10.1007/s00402-021-04173-8. [Extracted from the article]

The four members of the ErbB family of receptor tyrosine kinases are involved in development and tumorigenesis of the mammary gland. Whereas the epidermal growth factor receptor, ErbB2 and ErbB3 are positively associated with various cancers, clinical studies of ErbB4 in breast cancer are contradictory. Results from tissue culture analyses and some clinical studies suggested that ErbB4 is either a tumor suppressor or is a negative regulator of ErbB2-driven tumors. Neu-Cre-ErbB4flox/null mice in which ErbB4 was inactivated by Cre-lox-mediated recombination in the mammary gland developed MMTV-Neu-driven mammary tumors with a similar latency period to mice with one or two wild-type ErbB4 alleles. Moreover, there was no difference in the histologies of tumors that developed, nor in the propensity to form lung metastases. Taken together these results suggest that ErbB4 is not a potent, highly penetrant tumor suppressor, nor is it a factor in Neu-mediated tumorigenesis in this model.Oncogene (2006) 25, 5664–5672. doi:10.1038/sj.onc.1209574; published online 1 May 2006 [ABSTRACT FROM AUTHOR]