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Despite significant research advances on the seismic response analysis, there is still an urgent need for validation of numerical simulation methods for prediction of earthquake response and damage. In this respect, seismic monitoring networks and proper modelling can further support validation studies, allowing more realistic simulations of what earthquakes can produce. This paper discusses the seismic response of the "Pietro Capuzi" school in Visso, a village located in the Marche region (Italy) that was severely damaged by the 2016–2017 Central Italy earthquake sequence. The school was a two-story masonry structure founded on simple enlargements of its load-bearing walls, partially embedded in the alluvial loose soils of the Nera river. The structure was monitored as a strategic building by the Italian Seismic Observatory of Structures (OSS), which provided acceleration records under both ambient noise and the three mainshocks of the seismic sequence. The evolution of the damage pattern following each one of the three mainshocks was provided by on-site survey integrated by OSS data. Data on the dynamic soil properties was available from the seismic microzonation study of the Visso village and proved useful in the development of a reliable geotechnical model of the subsoil. The equivalent frame (EF) approach was adopted to simulate the nonlinear response of the school building through both fixed-base and compliant-base models, to assess the likely influence of soil–structure interaction on the building performance. The ambient noise records allowed for an accurate calibration of the soil–structure model. The seismic response of the masonry building to the whole sequence of the three mainshocks was then simulated by nonlinear time history analyses by using the horizontal accelerations recorded at the underground floor as input motions. Numerical results are validated against the evidence on structural response in terms of both incremental damage and global shear force–displacement relationships. The comparisons are satisfactory, corroborating the reliability of the compliant-base approach as applied to the EF model and its computational efficiency to simulate the soil–foundation–structure interaction in the case of masonry buildings. [ABSTRACT FROM AUTHOR]