1. Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method.
- Author
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Guangying Guan, Chunhui Li, Yuting Ling, Ying Yang, Vorstius, Jan B., Keatch, Robert P., Ruikang K. Wang, and Zhihong Huang
- Subjects
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COHERENCE (Optics) , *DISEASE progression , *BIOMEDICAL engineering , *ACOUSTIC radiation , *EPIDEMIOLOGY - Abstract
Damage of collagen fibers in tendons is often directly related to changes in a tendon's mechanical properties. Direct quantitative elasticity measurement of tendons will provide important information in tendon dysfunction diagnosis and treatment assessment. A feasibility study of quantifying the mechanical properties of a degenerated tendon model by a nondestructive imagingmodality, which combines optical coherence elastography and acoustic radiation force (ARF) method, is presented. The degenerated tendon model was produced by the partial degradation of chicken tendons through incubation with collagenase at different concentrations and incubation times. A 30-kHz longitudinal ultrasound transducer was used to provide an ARF signal, which was detected by an ultra-high sensitive phase sensitive optical coherence tomography (PhS-OCT) system. The experimental results demonstrate that the combination of ARF method and PhS-OCT can measure the elasticity of tendon quantitatively. The corresponding changes in tendon elasticity due to the application of collagenase have been revealed by this new imaging modality. This method can potentially be used in the assessment of tissue engineering products and in the diagnosis and treatment progression of tendon diseases [ABSTRACT FROM AUTHOR]
- Published
- 2013
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