1. Distinct pattern of lesion distribution in multiple sclerosis is associated with different circulating T-helper and helper-like innate lymphoid cell subsets.
- Author
-
Gross, Catharina C., Schulte-Mecklenbeck, Andreas, Hanning, Uta, Posevitz-Fejfár, Anita, Korsukewitz, Catharina, Schwab, Nicholas, Meuth, Sven G., Wiendl, Heinz, and Klotz, Luisa
- Subjects
- *
MULTIPLE sclerosis , *PRECANCEROUS conditions , *LYMPHOID tissue , *AUTOIMMUNE diseases , *FLOW cytometry - Abstract
Background: Distinct lesion topography in relapsing-remitting multiple sclerosis (RRMS) might be due to different antigen presentation and/or trafficking routes of immune cells into the central nervous system (CNS). Objective: To investigate whether distinct lesion patterns in multiple sclerosis (MS) might be associated with a predominance of distinct circulating T-helper cell subset as well as their innate counterparts. Methods: Flow cytometric analysis of lymphocytes derived from the peripheral blood of patients with exclusively cerebral (n = 20) or predominantly spinal (n = 12) disease manifestation. Results: Patients with exclusively cerebral or preferential spinal lesion manifestation were associated with increased proportions of circulating granulocyte-macrophage colony-stimulating factor (GM-CSF) producing TH1 cells or interleukin (IL)-17-producing TH17 cells, respectively. In contrast, proportions of peripheral IL-17/IL-22-producing lymphoid tissue inducer (LTi), the innate counterpart of TH17 cells, were enhanced in RRMS patients with exclusively cerebral lesion topography. Conclusions: Distinct T-helper and T-helper-like innate lymphoid cell (ILC) subsets are associated with different lesion topography in RRMS. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF