Objective: To retrospect the clinical features and the current situation of the diagnosis of patients with TSC in China to promote the identification, standardized diagnosis and management of patients with TSC. Methods: The literatures related to 3171 Chinese TSC patients selected from among 269 articles for further analysis with reference to the existence of skin lesions, neurological manifestations, renal, cardiac and pulmonary lesions were comprehensively searched in VIP, Wanfang, CNKI, CBM, and PubMed database from 2011 to 2014. Results: Compared to the main indications of the diagnostic criteria in 2012 TSC Diagnosis Guideline, a total of 247 papers described skin lesions on 2607 cases of TSC patients. The 2395 TSC patients from 212 papers were found to bear neurological lesion(s) based upon imaging data. A total of 84 TSC patients were reported to develop multiple retinal hamartoma as revealed by eye fundus examination on 348 patients studied in 55 papers. With color Doppler ultrasonography, 162 cases inflicted with rhabdomyoma of the heart were identified from out of 282 patients reported in 32 papers. X-ray chest film screening was conducted on282 patients in 45 papers and another 20 papers used chest CT scan to examine 36 patients, revealing up to a total of 50 cases of TSC patients with rhabdomyomatosis. Renal ultrasonongraphy was performed on 696 patients presented in 98 papers, while 221 cases in 51 papers had received renal CT scanning, and 2 separate papers described a total of 2 cases with renal MRI procedures, thus leading to the recognition of 416 cases of TSC to have angioleiomyoma in their kidneys. Through hepatic ultrasonography carried out for 586 cases with TSC in 58 papers, abdominal CT scan done on 104 cases in 30 papers and abdominal MRI on 3 cases in 2 papers, a total of 141 cases of TSC were found to have hepatic angioleiomyoma. In the reporting of secondary indications in diagnostic criteria, most of the multiple renal cystic disease were reported, but less oral fibroma and confetti skin lesion were reported. In the study about other clinical manifestations, the most reported were epilepsy, the literature about intelligence assessment still lacks objective intelligence evaluation standard. Genetic gene testing has gradually become the focus in recent years. Conclusion: Over the past 13 years, clinicians in China have done tremendously in diagnosing and treating the disease. However, due to the presence of misdiagnosis or omitted diagnosis,widespread adoption of TSC Diagnosis Guide would be advantageous. [ABSTRACT FROM AUTHOR] more...