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Great efforts have been made to develop precision medicine-based treatments using machine learning. In this field, where the goal is to provide the optimal treatment for each patient based on his/her medical history and genomic characteristics, it is not sufficient to make excellent predictions. The challenge is to understand and trust the model's decisions while also being able to easily implement it. However, one of the issues with machine learning algorithms—particularly deep learning—is their lack of interpretability. This review compares six different machine learning methods to provide guidance for defining interpretability by focusing on accuracy, multi-omics capability, explainability and implementability. Our selection of algorithms includes tree-, regression- and kernel-based methods, which we selected for their ease of interpretation for the clinician. We also included two novel explainable methods in the comparison. No significant differences in accuracy were observed when comparing the methods, but an improvement was observed when using gene expression instead of mutational status as input for these methods. We concentrated on the current intriguing challenge: model comprehension and ease of use. Our comparison suggests that the tree-based methods are the most interpretable of those tested. [ABSTRACT FROM AUTHOR]

Not only the expertise of people but also the collaboration among people are of great importance for a team. Given a set of experts with different skills, a social network that reflects the collaboration among people and a task, the team formation problem in social networks aims at forming a team to complete the task. The team is required to satisfy the skill requirements of the task and collaborates efficiently. Different communication cost functions have been proposed to have a good measure on the collaboration strength of a team in the existing work. However, the grouped organization structure inside team is never considered, which is very common in real life scenarios. In a grouped team, we are more concerned with the collaboration among people in same group and among leaders. In this paper, a novel communication cost function for a grouped team is proposed, and we define the Grouped Team Formation problem. To solve the problem, an exact algorithm is proposed. We further modify the exact algorithm to propose two heuristic algorithms with higher efficiency. Extensive experiments evaluate the effectiveness and efficiency of the proposed methods, and validate the reasonability of our problem definition in practical settings. [ABSTRACT FROM AUTHOR]

The assignment problem is an archetypal combinatorial optimization problem. This paper presents a neural network based on a dynamic model for solving the assignment problem. The main idea is to replace the assignment problem with a linear programming problem. On the basis of the Karush- Kuhn-Tucker optimality conditions, the equilibrium point of the proposed neural network is proved to be equivalent to the optimal solution of the original problem. It is also shown that the proposed neural network model is stable in the sense of Lyapunov and it is globally convergent to an exact optimal solution of the assignment problem. Block diagram of the proposed model is given. Several illustrative examples are provided to show the feasibility and the efficiency of the proposed method in this paper. [ABSTRACT FROM AUTHOR]