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On the southeastern margin of the Tibetan Plateau lies a large region which seismicity and GPS data show to be actively deforming. This paper describes the active faulting in the region, and how it relates to the velocity field observed with GPS. In places the velocity field is accommodated by rotations about vertical axes, and most or all of the strain at the surface in the region appears to be released seismically. GPS velocities are then compared to velocities calculated using a model for deformation driven by gravitational driving forces. Using rheologies estimated from experimentally derived mineral flow laws, the model provides velocities that are in good agreement with observed GPS velocities. It is not possible to uniquely determine the rheology or flow velocity at depth, and there are two forms of model solution which match the observed horizontal surface velocities. In one of these, vertical planes deform by pure shear, and in the other vertical gradients of horizontal velocity are present within the crust. Two distinct regions of normal-faulting earthquakes are present in the region, and have mechanisms which are most easily explained by gravity-driven deformation. [ABSTRACT FROM AUTHOR]