1. Hyperoxic recovery interferes with the metabolic imprint of hypoxic exercise.
- Author
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Burtscher, Johannes, Paglia, Giuseppe, Denti, Vanna, Faulhaber, Martin, Weiss, Günter, Schobersberger, Wolfgang, and Dünnwald, Tobias
- Subjects
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IRON in the body , *METABOLOMIC fingerprinting , *OXYGEN therapy , *PHYSICAL mobility , *ACCLIMATIZATION - Abstract
Supplemental oxygen (hyperoxia) improves physical performance during hypoxic exercise. Based on the analysis of metabolome and iron homeostasis from human athlete blood samples, we show that hyperoxia during recovery periods interferes with metabolic alterations following hypoxic exercise. This may impair beneficial adaptations to exercise and/or hypoxia and highlights risks of oxygen supplementation in hypoxia. [Display omitted] • Hyperoxic recovery does not improve training efficiency of hypoxic exercise in healthy men. • Hyperoxic recovery prevents inter-session improvements of hypoxic exercise. • Hyperoxic recovery abolishes the metabolic fingerprint of hypoxic exercise after one week. • Hyperoxic recovery during hypoxic exercise may reduce hypoxia acclimatization, potentially increasing the risks of hypoxia. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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