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Due to the similarity of the biomarker characteristics of the source rocks of different layers, the progress of the oil source research of the Yanchang Formation in the Ordos Basin is difficult and slow, which highlights the shortcomings of traditional research methods. Given this, this paper uses the gas chromatography-mass spectrometry analysis results of a large volume of samples of the Yanchang Formation in the basin as the dataset, and performs an exploratory application of the factor analysis (FA, a multivariate statistical method) to analyze the molecular geochemical characteristics of organic matter, with an aim to find features that have not been noticed in the past, and give a reasonable explanation for the oil source. The findings are summarized as below: with the help of multivariate (31 molecular geochemical parameters are introduced), FA can quantify many geochemical properties of samples well, which brings convenience to research. Based on the results, it was found that parameters such as C 26 TT/C 25 TT, sterane/hopane, and ΣC 19-26 TT/C 30 αβ can effectively distinguish the samples of different areas and layers, and it is further believed that the Chang 9 source rock has higher contributions to adjacent layers (mainly the Chang 8–Chang 10 oil groups) in areas where it is abundant (mainly the Wuqi-Zhidan area), while in the other areas and layers, oil is mostly attributed to the Chang 7 source rock. •Conventional oil-source research methods are inadequate when facing the Yanchang Fm. of Ordos Basin. •Exploratively combine factor analysis methods to analyze a large amount of GC-MS data. •Factor analysis effectively reveals differences in petroleum geochemistry among different source rocks. • This research has the potential value of promoting the development of petroleum geochemistry technology. [ABSTRACT FROM AUTHOR]

Abstract: Ethnopharmacological relevance: The lateral root of Aconitum has been popularly used in traditional Chinese medicine (TMC) known as Fuzi which is beneficial for the treatment of various diseases, such as rheumatism, painful joints, syncope and bronchial asthma. However, it has a potential carditoxicity with a relatively narrow margin of safety. Aim of the study: This paper was designed to explore the mechanisms of Fuzi's toxicity and find out potential tissue-specific biomarkers of toxic effects. Material and methods: A myocardial lipidomics based on ultraperformance lipid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC/Q-TOF MS) was developed to compare three cardiac lipid extraction methods and investigate the changes of lipids in mice heart of three different dosage groups. In addition, we concurrently inspected the biochemical parameters in plasma, observed the histology of the heart and recorded the electrocardiogram (ECG). Results: The cardiotoxicity of Fuzi was dose-dependent, and the high-dose group obviously manifested the heart damage in histology and a certain degree of arrhythmia. Significant changes of 14 lipid metabolites which primarily involved in phospholipid metabolism, sphingolipid metabolism, saturated fatty acid oxidation and unsaturated fatty acid peroxidation were identified and considered as the potential biomarkers of Fuzi toxicity. Conclusion: The lipidomics approach is helpful to search potential tissue-specific biomarkers and understand the underlying mechanisms of Fuzi toxicity on the heart. [Copyright &y& Elsevier]