1. اثر مکمل پری بیوتیک اینولین غنی شده با الیگو فروکتوز بر سطح لیپیدهای سرم و التهاب در بیماران مبتلا به دیابت نوع 2: یک کار آزمایی بالینی
- Author
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گرگری, بهرام پورقاسم, دهقان, پروین, میرطاهری, الهام, فغفوری, زینب, and کریمی, پوران
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ANALYSIS of covariance , *ANTHROPOMETRY , *C-reactive protein , *DIETARY supplements , *FRUCTOSE , *GLUCANS , *HIGH density lipoproteins , *INFLAMMATION , *LIPIDS , *OLIGOSACCHARIDES , *TYPE 2 diabetes , *PLACEBOS , *T-test (Statistics) , *TRIGLYCERIDES , *RANDOMIZED controlled trials , *PREBIOTICS , *DATA analysis software - Abstract
Background: Considering the high prevalence of diabetes and developing cardiovascular diseases through dyslipidemia and inflammation in type 2 diabetic patients, the aim of the present study was to investigate the effects of oligofructose-enriched inulin on serum lipid concentrations and inflammation in women with type 2 diabetes. Materials and Methods: In this clinical trial, 52 women with type 2 diabetes were randomly assigned to one of two groups. Experimental group (n=27) received 10g/day oligofructose-enriched inulin and control group (n=25) received 10g/day maltodextrin (placebo) for 8 weeks. Dietary intakes, anthropometric indicies, hs-CRP and serum lipids levels were measured at the baseline and at the end of the study. Data were analyzed using SPSS software (verision11.5). Paired, independent t-test and ANCOVA were used to compare comparison of quantitative variables. Results: At the end of study, significant decrease was observed in total cholesterol levels mean (28.00 mg/dL, 14.10%), LDL-c (22.00 mg/dL, 21.70%), TC/HDL-c ratio (0.73, 20.70%) and LDL-c/HDL-c ratio (0.55, 27.50%) in oligofructose-enriched inulin compared with the maltodextrin group (p=0.03). Changes in concentrations of triglycerides, hsCRP and high-density lipoprotein were not significant in oligofructose-enriched inulin compared to maltodextrin group. Conclusions: Oligofructose-enriched inulin supplementation with improving in inflammtion and lipid profile help in management of type 2 diabetes and its complications. [ABSTRACT FROM AUTHOR]
- Published
- 2013