1. microRNAs and the Operon Paper
- Author
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Rajewsky, Nikolaus
- Subjects
- *
RNA , *GENE expression , *GENETIC regulation , *EUKARYOTIC cells , *CARRIER proteins , *GENETIC research , *PERIODICAL articles , *INSIGHT - Abstract
Abstract: The “Operon paper” by F. Jacob and J. Monod started 50 years of research into understanding how the expression of genes is regulated on a molecular level. Ten years ago, microRNAs (miRNAs) emerged as major regulators of eukaryotic gene expression. Here, I will review the basic principles of gene regulation by miRNAs and how these principles can be linked to insights from the Operon paper. A lot of what is understood about miRNAs required a combination of computational and experimental methods. I will discuss some examples that illustrate the power of this approach. [Copyright &y& Elsevier]
- Published
- 2011
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