27 results on '"Dong, Xiang"'
Search Results
2. Sirt5‐mediated lysine desuccinylation regulates oxidative stress adaptation in Magnaporthe oryzae during host intracellular infection.
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Ren, Zhiyong, Dong, Xiang, Guan, Lun, Yang, Lei, Liu, Caiyun, Cai, Xuan, Hu, Hong, Lv, Ziwei, Liu, Hao, Zheng, Lu, Huang, Junbin, Wilson, Richard A., and Chen, Xiao‐Lin
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PYRICULARIA oryzae , *OXIDATIVE stress , *MITOCHONDRIAL proteins , *PATHOGENIC fungi , *PHYTOPATHOGENIC fungi - Abstract
Summary: Plant pathogenic fungi elaborate numerous detoxification strategies to suppress host reactive oxygen species (ROS), but their coordination is not well‐understood.Here, we show that Sirt5‐mediated protein desuccinylation in Magnaporthe oryzae is central to host ROS detoxification. SIRT5 encodes a desuccinylase important for virulence via adaptation to host oxidative stress. Quantitative proteomics analysis identified a large number of succinylated proteins targeted by Sirt5, most of which were mitochondrial proteins involved in oxidative phosphorylation, TCA cycle, and fatty acid oxidation.Deletion of SIRT5 resulted in hypersuccinylation of detoxification‐related enzymes, and significant reduction in NADPH : NADP+ and GSH : GSSG ratios, disrupting redox balance and impeding invasive growth. Sirt5 desuccinylated thioredoxin Trx2 and glutathione peroxidase Hyr1 to activate their enzyme activity, likely by affecting proper folding.Altogether, this work demonstrates the importance of Sirt5‐mediated desuccinylation in controlling fungal process required for detoxifying host ROS during M. oryzae infection. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Assembly and comparative analysis of the initial complete mitochondrial genome of Primulina hunanensis (Gesneriaceae): a cave-dwelling endangered plant.
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Chen, Lingling, Dong, Xiang, Huang, Hang, Xu, Haixia, Rono, Peninah Cheptoo, Cai, Xiuzhen, and Hu, Guangwan
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MITOCHONDRIAL DNA , *PLANT mitochondria , *ENDANGERED plants , *GESNERIACEAE , *CHLOROPLAST DNA , *ORNAMENTAL plants , *COMPARATIVE genomics - Abstract
Background: Primulina hunanensis, a troglobitic plant within the Primulina genus of Gesneriaceae family, exhibits robust resilience to arid conditions and holds great horticultural potential as an ornamental plant. The work of chloroplast genome (cpDNA) has been recently accomplished, however, the mitochondrial genome (mtDNA) that is crucial for plant evolution has not been reported. Results: In this study, we sequenced and assembled the P. hunanensis complete mtDNA, and elucidated its evolutionary and phylogenetic relationships. The assembled mtDNA spans 575,242 bp with 43.54% GC content, encompassing 60 genes, including 37 protein-coding genes (PCGs), 20 tRNA genes, and 3 rRNA genes. Notably, high number of repetitive sequences in the mtDNA and substantial sequence translocation from chloroplasts to mitochondria were observed. To determine the evolutionary and taxonomic positioning of P. hunanensis, a phylogenetic tree was constructed using mitochondrial PCGs from P. hunanensis and 32 other taxa. Furthermore, an exploration of PCGs relative synonymous codon usage, identification of RNA editing events, and an investigation of collinearity with closely related species were conducted. Conclusions: This study reports the initial assembly and annotation of P. hunanensis mtDNA, contributing to the limited mtDNA repository for Gesneriaceae plants and advancing our understanding of their evolution for improved utilization and conservation. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Interactions of the pseudoscalar meson octet and the baryon decuplet in the continuum and a finite volume.
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Ji, Teng, Dong, Xiang-Kun, and Meißner, Ulf-G.
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CHIRAL perturbation theory , *BARYONS , *PARAMETERIZATION - Abstract
This study focuses on the interaction of the pseudoscalar meson octet and the baryon decuplet. In the continuum, it is observed that several J P = 3 2 - baryon resonances can be produced by the Weinberg-Tomozawa interaction in unitarized chiral perturbation theory, including the N(1875), Σ (1670) , Σ (1910) , Ξ (1820) and Ω (2012) . Among them, the Ξ (1820) and Σ (1670) may exhibit a potential two-pole structures. The unitarized chiral perturbation approach is then applied as the underlying theory to predict the energy levels of these systems in a finite volume. These energy levels are well described by the K-matrix parameterization constrained by flavor SU(3) symmetry. With the parameters from the best fits, the poles extracted from the K-matrix parameterization closely correspond to those derived from the underlying chiral effective field theory, as long as they are close to physical region and not significantly higher than the lowest relevant threshold. [ABSTRACT FROM AUTHOR]
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- 2024
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5. miR-30c affects the pathogenesis of ulcerative colitis by regulating target gene VIP.
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Dong, Xiang, Zhan, Yuling, Yang, Minghui, Li, Suwan, Zheng, Hailun, and Gao, Yu
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ULCERATIVE colitis , *VASOACTIVE intestinal peptide , *PATHOGENESIS , *GENE expression , *DEXTRAN sulfate - Abstract
MicroRNAs play a crucial role in regulating the epithelial barrier and immune response, which are implicated in the pathogenesis of ulcerative colitis (UC). This study aimed to investigate the role and molecular mechanism of miR-30c in the pathogenesis of UC using a dextran sulfate sodium salt (DSS)-induced colitis model, which is similar to ulcerative colitis. Wild-type (WT) and miR-30c knockout (KO) mice were assigned to either control or DSS-treated groups to evaluate the influence of aberrant miR-30c expression on UC pathogenesis. The disease activity index, inflammatory factors, and the extent of pathological and histological damage in colon tissues were analyzed. The effect of miR-30c on vasoactive intestinal peptide (VIP) gene expression was validated through luciferase reporter assay, qRT-PCR, Western blotting, and immunohistochemistry. The results showed that miR-30c KO mice with DSS-induced colitis model showed more severe phenotypes: significantly higher disease activity indices, significant body weight loss, reduced length of the colon of mice, increased number of aberrant crypt structures, reduced mucus secretion, and significant differences in inflammatory factors. These findings suggested that the absence of miR-30c might promote DSS-induced colitis, and the targe-regulatory effect of miR-30c on VIP might play an important role in the development of colitis. [ABSTRACT FROM AUTHOR]
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- 2024
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6. APTES modification of ZIF-67@M(OH)(OCH3) for enhanced flame retardancy and mechanical properties of epoxy resins.
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Dong, Xiang, Li, De-long, Xie, Le, Fan, Xiangguang, and Feng, Yu-xin
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FIREPROOFING , *EPOXY resins , *METAL-organic frameworks , *FLAMMABILITY , *THERMAL stability , *ENERGY storage , *COAL combustion - Abstract
In this work, we employed a two-step modification process to improve the properties of 2D bimetallic nanoplates M(OH)(OCH3) (M = Co, Ni), which were recently proven as a promising "nano-flame retardant". The nanoplates were in situ modified with metal-organic framework ZIF-67 first and then silanized with a coupling agent APTES. Epoxy resin (EP) nanocomposites were fabricated using the functionalized M(OH)(OCH3). We investigated the performance of the nanocomposites in flame retardance and thermal stability. The results showed that 3% of APTES@ZIF-67@M(OH)(OCH3) gave the EP nanocomposite the V-1 rating in UL-94 test and the highest limited oxygen index of 27.6%. Moreover, the pHRR value of EP/APTES@ZIF-67@M 3% was reduced by 20.0% and 9.6%, respectively, compared to neat EP and EP/ZIF-67@M 3%. Regarding the mechanical properties, the Tensile properties and energy storage modulus of EP nanocomposite were both improved with 3% of APTES@ZIF-67@M(OH)(OCH3). The GC-MS test results revealed that the functionalized M(OH)(OCH3) significantly increased the cross-linking propensity of the EP matrix upon combustion, leading to the formation of a dense char layer. This study demonstrates the great potential of M(OH)(OCH3) as a highly efficient "nano-flame retardant" with tunable functionality. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Fraction constraint in partial wave analysis.
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Dong, Xiang, Pan, Chu-Cheng, Sun, Yu-Chang, Cheng, Ao-Yan, Wang, Ao-Bo, Cai, Hao, and Zhu, Kai
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PARTICLE physics , *WAVE analysis , *FRACTIONS - Abstract
To resolve the nonconvex optimization problem in partial wave analysis, this paper introduces a novel approach that incorporates fraction constraints into the likelihood function. This method offers significant improvements in the efficiency of pole searching within partial wave analysis. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Small ion pulse ionization chamber for radon measurement in underground space.
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Dong, Xiang-Long, Ma, Zi-ji, Jiang, Zhi-wen, Wang, Qi, and Gou, Rui
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RADON detectors , *NUCLEAR counters , *IONIZATION chambers , *UNDERGROUND areas , *IONIZING radiation - Abstract
Radon, prevalent in underground spaces, requires continuous monitoring due to health risks. Traditional detectors are often expensive, bulky, and ill-suited for humid environments in underground spaces. This study presents a compact, cost-effective radon detector designed for long-term, online monitoring. It uses a small ionization chamber with natural airflow, avoiding the need for fans or pumps, and includes noise filtering and humidity mitigation. Featuring multi-point networking and easy integration capabilities, this detector significantly enhances radon monitoring in challenging, underground conditions. • The structure and characteristics of a small cylindrical ion-pulsed ionization chamber are described. • The detector has mechanical noise filtering, and some measures have been taken to reduce the effect of air humidity. • The design feasibility is discussed from the perspectives of theory, simulation and physical objects. [ABSTRACT FROM AUTHOR]
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- 2024
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9. Destruction mechanism of anterior cervical discectomy and fusion in frontal impact.
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Guo, Li-Xin, Zhang, Dong-Xiang, and Zhang, Ming
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DISCECTOMY , *FINITE element method , *CERVICAL vertebrae , *NECK muscles , *VERTEBRAE , *SPINAL injuries , *SPINAL surgery - Abstract
The aim of this study was to quantitatively study the effect of anterior cervical discectomy and fusion (ACDF) on the risk of spinal injury under frontal impact. A head-neck finite element model incorporating active neck muscles and soft tissues was developed and validated. Based on the intact head-neck model, three ACDF models (single-level, two-level and three-level) were used to analyze the frontal impact responses of the head-neck. The results revealed that various surgical approaches led to distinct patterns of vertebral damage under frontal impact. For single-level and three-level ACDFs, vertebral destruction was mainly concentrated at the lower end of the fused segment, while the other vertebrae were not significantly damaged. For two-level ACDF, the lowest vertebra was the first to suffer destruction, followed by severe damage to both the upper and lower vertebrae, while the middle vertebra of the cervical spine exhibited only partial damage around the screws. Fusion surgery for cervical spine injuries predominantly influences the vertebral integrity of the directly fused segments when subjected to frontal impact, while exerting a comparatively lesser impact on the cross-sectional properties of adjacent, non-fused segments.Graphical abstract: The aim of this study was to quantitatively study the effect of anterior cervical discectomy and fusion (ACDF) on the risk of spinal injury under frontal impact. A head-neck finite element model incorporating active neck muscles and soft tissues was developed and validated. Based on the intact head-neck model, three ACDF models (single-level, two-level and three-level) were used to analyze the frontal impact responses of the head-neck. The results revealed that various surgical approaches led to distinct patterns of vertebral damage under frontal impact. For single-level and three-level ACDFs, vertebral destruction was mainly concentrated at the lower end of the fused segment, while the other vertebrae were not significantly damaged. For two-level ACDF, the lowest vertebra was the first to suffer destruction, followed by severe damage to both the upper and lower vertebrae, while the middle vertebra of the cervical spine exhibited only partial damage around the screws. Fusion surgery for cervical spine injuries predominantly influences the vertebral integrity of the directly fused segments when subjected to frontal impact, while exerting a comparatively lesser impact on the cross-sectional properties of adjacent, non-fused segments. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Integrated transcriptomics and metabolomics revealed the mechanism of catechin biosynthesis in response to lead stress in tung tree (Vernicia fordii).
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Dong, Xiang, Li, Wenying, Li, Changzhu, Akan, Otobong Donald, Liao, Chancan, Cao, Jie, and Zhang, Lin
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- 2024
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11. Correction: Single molecule magnet features in luminescent lanthanide coordination polymers with heptacoordinate Dy/Yb(III) ions as nodes.
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Dong, Xiang-Tao, Yu, Meng-Qing, Peng, Yong-Bo, Zhou, Guo-Xing, Peng, Guo, and Ren, Xiao-Ming
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SINGLE molecule magnets , *COORDINATION polymers , *RARE earth metals , *IONS - Abstract
Correction for 'Single molecule magnet features in luminescent lanthanide coordination polymers with heptacoordinate Dy/Yb(III) ions as nodes' by Xiang-Tao Dong et al., Dalton Trans., 2023, 52, 12686–12694, https://doi.org/10.1039/D3DT02106H. [ABSTRACT FROM AUTHOR]
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- 2024
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12. Hints of the JPC = 0−− and 1−−[formula omitted] molecules in the J/ψ → ϕηη′ decay.
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Dong, Xiang-Kun, Ji, Teng, Guo, Feng-Kun, Meißner, Ulf-G., and Zou, Bing-Song
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SCATTERING amplitude (Physics) , *ANGULAR distribution (Nuclear physics) , *MOLECULES , *PIONS , *VECTOR mesons , *HADRONIC atoms - Abstract
The primary objective of this study is to investigate hadronic molecules of K ⁎ K ¯ 1 (1270) using a one-boson-exchange model, which incorporates exchanges of vector and pseudoscalar mesons in the t -channel, as well as the pion exchange in the u -channel. Additionally, careful consideration is given to the three-body effects resulting from the on-shell pion originating from K 1 (1270) → K ⁎ π. Then the BESIII data of the J / ψ → ϕ η η ′ process is fitted using the K ⁎ K ¯ 1 (1270) scattering amplitude with J P C = 0 − − or 1 − −. The analysis reveals that both the J P C = 0 − − and 1 − − assumptions for K ⁎ K ¯ 1 (1270) scattering provide good descriptions of the data, with similar fit qualities. Notably, the parameters obtained from the best fits indicate the existence of K ⁎ K ¯ 1 (1270) bound states, denoted by ϕ (2100) and ϕ 0 (2100) for the 1 − − and 0 − − states, respectively. The current experimental data, including the η polar angular distribution, cannot distinguish which K ⁎ K ¯ 1 (1270) bound state contributes to the J / ψ → ϕ η η ′ process, or if both are involved. Therefore, we propose further explorations of this process, as well as other processes, in upcoming experiments with many more J / ψ events to disentangle the different possibilities. [ABSTRACT FROM AUTHOR]
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- 2024
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13. Correction: Dong et al. Computerized Ionospheric Tomography Based on the ADS-B System. Atmosphere 2023, 14 , 1091.
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Dong, Xiang, Yuan, Zhigang, Zhu, Qinglin, Wang, Haining, Sun, Fang, Zhu, Jiawei, Liu, Yi, and Zhou, Chen
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COMPUTED tomography , *IONOSPHERIC electron density - Abstract
This correction notice addresses an issue with the citation in a publication titled "Computerized Ionospheric Tomography Based on the ADS-B System." The work by Cushley et al. was not properly cited in the original publication, and the correction has now been made. The authors assure that this correction does not affect the scientific conclusions of the publication. The original publication has been updated to reflect this correction. [Extracted from the article]
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- 2024
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14. A novel nanohybrid, Fe3O4/NHS@M(OH)(OCH3)@rGO (M= Co, Ni), with petal-shaped anisotropic interfaces imparts efficient EMW absorption, flame retardancy, and thermal management properties to epoxy resin.
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Dong, Xiang, Sun, Zhiyu, Li, De-long, Duan, Qiancheng, Ma, Yan, and Liu, Song
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FIREPROOFING , *ELECTROMAGNETIC wave absorption , *THERMAL management (Electronic packaging) , *EPOXY resins , *REAL estate management , *CARBON-based materials - Abstract
As epoxy resin (EP) is widely used in the microelectronic field, it is essential to improve its electromagnetic wave (EMW) absorption and flame retardancy simultaneously. In this work, we synthesized a novel nanohybrid, RMN (Fe 3 O 4 /NHS@M(OH)(OCH 3)@rGO (M = Co, Ni)), with petal-shaped anisotropic interfaces, by using graphene oxide as the core and the 2D nanosheets M(OH)(OCH 3) (M = Co, Ni) as the petal, with nickel hydroxystannate and ferrite as further modifications. The RMN combines carbon-based materials, ferrites and conductors, and represents the petal-like structure with rich nondirectional interfaces. The results show that EP composite containing 25 wt% RMN represented excellent EMW absorption, with a minimum reflection loss of −55.79 dB (with 7.4 mm thickness at 3.1 GHz). Moreover, the EP composite with 15 wt% RMN (EP/RMN700-3) had the lowest peak heat release rate of 470.9 kW m−2, which was 69.7 % lower than pure EP, showing a significantly improving in flame retardant. The thermal conductivity efficiency of EP/RMN700-3 increased to 128.4 % compared with the pure EP, which effectively reduces fire risk caused by heat accumulation. This study provides a valuable solution to overcome the challenges of EMW absorption and flame retardant for EP in the microelectronic materials field. [Display omitted] • The nonoriented petal-like structure provides rich interface. • Carbon materials, ferrites and conductors support the multiple absorbing mechanisms. • EMW absorption, flame retardant and thermal management suit for electronic packaging. [ABSTRACT FROM AUTHOR]
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- 2024
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15. Heat-triggered shape recovery, EMI shielding and flame retardant: A novel cellulose/M(OH)(OCH3)@dopamine@Ag (M=Co, Ni) nanopaper for early fire alarm.
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Dong, Xiang, Dai, Guo-wei, Xie, Le, Li, De-long, Sun, Zhiyu, and Liu, Song
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FIRE alarms , *FIREPROOFING agents , *FIRE resistant polymers , *HEAT release rates , *METHYLCELLULOSE , *CELLULOSE , *ELECTROMAGNETIC shielding - Abstract
Fire alarm systems are essential for protecting lives and properties from fire hazards. However, most of the existing fire alarm nanopapers rely on the resistance reduction after heating, which requires direct contact with the flame. In this study, we present a novel fire alarm nanopaper (CMPA) based on heat-triggered shape recovery. The CMPA is composed of hydroxypropyl methyl cellulose (HPMC) as the matrix and 2D nanomaterials M(OH)(OCH 3) as fillers. When the temperature of CMPA exceeded the glass transition, the thrice-folded CMPA-1.0 flattened in 30s and connected to the alarm circuit based on its conductive surface. According to the results, the CMPA-1.0 with a thickness of about 0.2 mm had an efficient electromagnetic shielding of 42.1 dB. Moreover, the CMPA-1.0 self-extinguished rapidly after being ignited with its original shape preserved. The peak heat release rate of CMPA-1.0 was 108.9 W/g, which was 61.9 % lower than that of HPMC. Furthermore, the thermal conductivity of CMPA-1.0 reached to 0.317 W m−1 K−1, which was 40.8 % higher than that of HPMC, reducing the heat accumulation effectively. This work shows that CMPA is an ideal material for sensitive and safe early fire alarm, and the strategy based on heat-triggered shape recovery is promising in fire alarm application. [ABSTRACT FROM AUTHOR]
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- 2024
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16. Dynamic characteristics of multiple droplets impinging on the wall of a liquid droplet radiator.
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Dong, Xiang, Zhao, Fulong, Zhao, Yuan, Tan, Sichao, Wang, Xianbo, and Tian, Ruifeng
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LIQUID films , *RADIATORS , *DROPLETS , *SURFACE tension , *THICK films , *REYNOLDS number , *DIMENSIONLESS numbers - Abstract
In this paper, a numerical simulation method is used to study the process of multiple droplets impact on the wall of a liquid droplet radiator in a space environment. The effects of droplet spacing, droplet velocity, wall properties and other factors on the evolution of droplet impact on the wall are analyzed. The results show that the critical Reynolds number of droplets without splashing decreases and then remains unchanged as the droplet spacing of silicone oil increases. Thin liquid film promotes droplet splashing, while thick liquid film inhibits droplet splashing. The larger the initial incident velocity of the droplets, the larger the number of splashing droplets and the smaller their diameters. The critical Reynolds number of silicone oil droplets decreases monotonously with the increase of the inclination angle between the wall and the vertical direction. Finally, a 15° frustum of a cone model is chosen to simulate the actual working process of the liquid droplet radiator to verify the conclusions. The results of the study can provide guidance for the optimal design of droplet collectors. • Studying how droplet features and wall properties affect droplet impact on surface. • Analyzing how liquid film thickness affects splashing type and droplet state. • Exploring how surface tension and viscosity impact splash formation. • Identifying droplet collector parameters based on dimensionless number variation. • Results offer theoretical support for optimal droplet collector design. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Expression profile of microRNAs in patients with decompensated cirrhosis by small RNA deep sequencing.
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Zhang, Li, Dong, Xiang, Zhan, Yuling, Ma, Shasha, Liu, Chuanmiao, and Gao, Yu
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RNA sequencing , *GENE expression , *NON-coding RNA , *REVERSE transcriptase polymerase chain reaction , *MICRORNA - Abstract
• Identification of miRNA biomarkers in DCC and LC blood samples. • Accurate diagnosis of DCC using miRNA-based logistic regression model. • Potential of three microRNAs as DCC biomarkers and therapeutic targets. • Insights into molecular mechanisms underlying DCC progression from miRNA analysis. Decompensated cirrhosis (DCC) is a more advanced stage of liver cirrhosis (LC). It is important to identify biomarkers to predict DCC progression. The aim of this study was to analyze microRNA (miRNA) profiles of whole blood involved in the DCC process to gain a better understanding of the molecular mechanisms underlying its development. RNA-Seq analysis of blood samples from a discovery set, including four DCC patients and four LC individuals, was performed to identify differentially expressed miRNAs. The selected differentially expressed miRNAs were validated by using an independent validation set. In this study, a total of 1,036 miRNAs were identified in whole blood samples. Forty differentially expressed miRNAs were identified, including 24 upregulated and 16 downregulated miRNAs. The expression levels of three upregulated miRNAs (hsa-miR-20b-5p, hsa-miR-421, and hsa-miR-1307-3p) and two downregulated miRNAs (hsa-miR-139-5p and hsa-miR-150-5p) were validated by quantitative reverse transcriptase polymerase chain reaction. The receiver operator characteristic curve for the logistic regression model based on hsa-miR-20b-5p, hsa-miR-421, and hsa-miR-150-5p could distinguish DCC patients with excellent diagnostic accuracy (area under the curve: 0.981, p < 0.01). The miRNA expression profiles in patients with DCC and LC controls suggested that miR-20b-5p, miR-421, and miR-150-5p could be potential biomarkers and therapeutic targets for this condition. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Flying Target Detection Technology Based on GNSS Multipath Signals.
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Zhu, Pengfei, Zhu, Qinglin, Dong, Xiang, and Sun, Mingchen
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GLOBAL Positioning System , *BISTATIC radar , *PASSIVE radar , *RECEIVING antennas - Abstract
In this study, a passive radar system that detects flying targets is developed in order to solve the problems associated with traditional flying target detection systems (i.e., their large size, high power consumption, complex systems, and poor battlefield survivability). On the basis of target detection, the system uses the multipath signal (which is usually eliminated as an error term in navigation and positioning), enhances it by supporting information, and utilizes the multi-source characteristics of ordinary omnidirectional global navigation satellite system (GNSS) signals. The results of a validation experiment showed that the system is able to locate a passenger airplane and obtain its flight trajectory using only one GNSS receiving antenna. The system is characterized by its light weight (less than 5 kg), low power consumption, simple system, good portability, low cost, and 24/7 and all-weather work. It can be installed in large quantities and has good prospects for development. [ABSTRACT FROM AUTHOR]
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- 2024
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19. Comparison of long-term quality of life and their predictors in survivors between paediatric and adult nasopharyngeal carcinoma in the intensity-modulated radiotherapy era.
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Jin, Jing, Guo, Shan-Shan, Liu, Li-Ting, Wen, Dong-Xiang, Liu, Rong-Ping, Lin, Jie-Yi, Liu, Si-Qi, Sun, Xue-Song, Liang, Yu-Jing, Tang, Lin-Quan, Mai, Hai-Qiang, and Chen, Qiu-Yan
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Background: To compare the differences in long-term quality of life (QoL) between survivors of paediatric and adult patients with nasopharyngeal carcinoma (NPC) and assess the clinical factors that predict long-term QoL. Methods: We enrolled 420 long-term NPC survivors who were alive for at least 8 years after treatment, including 195 paediatric and 225 adult patients diagnosed and treated with intensity-modulated radiotherapy (IMRT) at Sun Yat-sen University Cancer Centre (SYSUCC) between 2011 and 2015. Data on clinical factors and EORTC QLQ-C30 were collected from all participants. The QoL of paediatric and adult NPC survivors was compared. Results: The paediatric group had significantly better outcomes in global health status (paediatric: 80.2 ± 12.7; adult: 77.2 ± 11.5; P = 0.027), physical function (paediatric: 98.5 ± 4.6; adult: 95.1 ± 7.0; P < 0.001), role function (paediatric: 97.0 ± 9.2; adult: 90.5 ± 15.2; P < 0.001), social function (paediatric: 96.0 ± 8.9; adult: 93.5 ± 11.8; P = 0.038), insomnia (paediatric: 1.9 ± 7.8; adult: 13.1 ± 22.3; P < 0.001), constipation (paediatric: 1.3 ± 7.5; adult: 8.0 ± 17.4; P < 0.001), diarrhea (paediatric: 0.7 ± 4.6; adult: 2.8 ± 9.3; P = 0.010), and financial difficulties (paediatric: 1.9 ± 7.8; adult: 11.0 ± 19.8; P < 0.001), but poorer cognitive function (paediatric: 88.3 ± 9.9; adult: 93.8 ± 12.6; P < 0.001) than the adult group. Pretreatment clinical factors, including T stage, N stage, and pre-treatment EBV (Epstein-Barr Virus) DNA, showed a strong association with QoL. However, the factors that affected the QoL outcomes differed between the two groups. In survivors of paediatric cancer, global health status/QoL was strongly correlated with T stage (P < 0.001) and clinical stage (P = 0.018), whereas it was strongly correlated with pre-treatment EBV DNA (P = 0.008) in adults. Conclusion: Paediatric survivors of NPC have a significantly better QoL than adult NPC survivors. Moreover, pre-treatment T stage, N stage, and EBV DNA significantly influenced the overall health status of the survivors. These results highlight the need to tailor care to both age groups to promote better long-term health outcomes. [ABSTRACT FROM AUTHOR]
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- 2024
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20. Curcumin-mediated enhancement of lung barrier function in rats with high-altitude-associated acute lung injury via inhibition of inflammatory response.
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Yang, Xinyue, Li, Jiajia, Ma, Yan, Dong, Xiang, Qu, Jinquan, Liang, Feixing, and Liu, Jiangwei
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TUMOR necrosis factors , *TIGHT junctions , *BLOOD lactate , *ENZYME-linked immunosorbent assay , *BLOOD gases - Abstract
Background: Exposure to a hypobaric hypoxic environment at high altitudes can lead to lung injury. In this study, we aimed to determine whether curcumin (Cur) could improve lung barrier function and protect against high-altitude-associated acute lung injury. Methods: Two hundred healthy rats were randomly divided into standard control, high-altitude control (HC), salidroside (40 mg/kg, positive control), and Cur (200 mg/kg) groups. Each group was further divided into five subgroups. Basic vital signs, lung injury histopathology, routine blood parameters, plasma lactate level, and arterial blood gas indicators were evaluated. Protein and inflammatory factor (tumor necrosis factor α (TNF-α), interleukin [IL]-1β, IL-6, and IL-10) concentrations in bronchoalveolar lavage fluid (BALF) were determined using the bicinchoninic acid method and enzyme-linked immunosorbent assay, respectively. Inflammation-related and lung barrier function-related proteins were analyzed using immunoblotting. Results: Cur improved blood routine indicators such as hemoglobin and hematocrit and reduced the BALF protein content and TNF-α, IL-1β, and IL-6 levels compared with those in the HC group. It increased IL-10 levels and reduced pulmonary capillary congestion, alveolar hemorrhage, and the degree of pulmonary interstitial edema. It increased oxygen partial pressure, oxygen saturation, carbonic acid hydrogen radical, and base excess levels, and the expression of zonula occludens 1, occludin, claudin-4, and reduced carbon dioxide partial pressure, plasma lactic acid, and the expression of phospho-nuclear factor kappa. Conclusions: Exposure to a high-altitude environment for 48 h resulted in severe lung injury in rats. Cur improved lung barrier function and alleviated acute lung injury in rats at high altitudes. Highlights: • Curcumin (Cur) improves lung barrier function under high-altitude stress in rats • Cur mitigated acute lung injury under high-altitude stress • Cur improved hemoglobin and hematocrit levels under high-altitude stress • Cur reduced bronchoalveolar lavage fluid protein content under high-altitude stress • Cur reduced inflammatory factor TNF-α, IL-α, IL-6 levels under high-altitude stress [ABSTRACT FROM AUTHOR]
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- 2024
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21. Curcumin alleviates heatstroke-induced liver injury in dry-heat environments by inhibiting the expression of NF-κB, iNOS, and ICAM-1 in rats.
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Yang, Xinyue, Xia, Liang, Shen, Caifu, Li, Jiajia, Dong, Xiang, and Liu, Jiangwei
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CD54 antigen , *NF-kappa B , *LABORATORY rats , *NITRIC-oxide synthases , *CURCUMIN - Abstract
we aimed to monitor liver injury in rat model during heat stress and heatstroke in dry-heat environment and investigate the effects of curcumin on heatstroke-induced liver injury and the underlying mechanisms. Sprague-Dawley (SD) rats were randomly divided into four groups: normal saline (NS), and 50 (50-cur), 100 (100-cur), and 200 mg/kg curcumin (200-cur) groups. They were administered the indicated doses of curcumin by gavage once daily for 7 days. On day 8, the rats were transferred to a simulated climate cabin, At 0, 50, 100, and 150 min, the core temperature (Tc) was measured respectively. After sacrificing the rats, tissue samples were collected, measure histology indices, serum enzymes, lipopolysaccharides (LPSs), cytokines, nuclear factor-kappa B (NF-κB), inducible nitric oxide synthase (iNOS), and intercellular adhesion molecule-1 (ICAM-1). The Tc increased with time in all groups. Curcumin alleviation of symptoms and improvement in pathological scores. The level of enzymes, LPS, and cytokines increased during heatstroke in the NS group, but curcumin decreased the levels of these indicators. The differences of the indicators between NS and 200-cur groups at 150 min were significant (P < 0.05). The expression of NF-κB p65, iNOS, and ICAM-1 was upregulated in the NS group at 150 min, but their expression was relatively lower in the curcumin groups (P < 0.05). Thus, our findings indicate acute liver injury during heat stress and heatstroke. The mechanism involves cascade-amplification inflammatory response induced by the gut endotoxin. Furthermore, curcumin alleviated heatstroke-induced liver injury in a dose-dependent manner by downregulating NF-κB, iNOS, and ICAM-1. [ABSTRACT FROM AUTHOR]
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- 2024
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22. Preparation and Properties of 3D Spherical Bi2S3/Bi2O2CO3 Photocatalytic Materials Self‐Assembled by 2D Nanosheets.
- Author
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Zhou, Ce, Wang, Xiao‐li, Yu, Hui, Yang, Ming, Dong, Xiang‐ting, and Yang, Ying
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ENERGY levels (Quantum mechanics) , *CONDUCTION bands , *BAND gaps , *QUANTUM dots , *VALENCE bands , *PHOTOCATALYSIS - Abstract
ABSTRACT The micro‐morphology of photocatalytic materials has a great influence on their photocatalytic performance. Quantum dots can provide the plasmon resonance effect and broaden the wavelength range of light absorption. In this study, a kind of 3D spherical flower‐like structure was constructed by self‐assembly of 2D nanosheets, the Bi2S3 particles with 5 ± 1 nm diameter were modified on the surfaces of Bi2O2CO3 nanosheets to prepare the Bi2S3/Bi2O2CO3 composite. The energy level difference (0.45 eV) between the conduction bands (CB) of Bi2S3 and Bi2O2CO3 led to which the e− was transferred to CB of Bi2O2CO3. The energy level difference (0.83 eV) between the CB of Bi2O2CO3 and the valence band (VB) of Bi2S3 was much smaller than the band gap (1.28 eV) of Bi2S3, and it led to which the electrons on the CB of Bi2O2CO3 were recombined with the holes on the VB of Bi2S3. A kind of innovative type heterojunction was constructed between Bi2S3 and Bi2O2CO3, which encouraged the photogenerated h+ and ·OH to be located on the VB of Bi2O2CO3 with the strongest oxidation potential, the prepared material showed excellent performance for the photodegradation of RhB, and the active groups were also controlled in the photocatalysis process. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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23. Low-temperature growth of high-quality VO2 epitaxial film on c-plane sapphire by reactive magnetron sputtering.
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Liu, Chang, Zheng, Zhi, Li, Xing, Wang, Yang, Dong, Xiang, Huang, Gaoshan, and Mei, Yongfeng
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REACTIVE sputtering , *MAGNETRON sputtering , *SUBSTRATES (Materials science) , *LOW temperatures , *HIGH temperatures , *SAPPHIRES - Abstract
The growth of VO2 epitaxial films has been researched extensively for obtaining excellent phase-transition performance. However, previous methods typically necessitate high temperatures or post-annealing processes, which elevate both experimental complexity and cost. In this work, we prepared high-quality VO2 epitaxial films by reactive magnetron sputtering directly under a low growth temperature. Benefiting from the determination of the oxygen pressure ratio from the theoretical analysis of the sputtering process model, single-stoichiometric VO2 epitaxial films could be prepared under 450 °C with a resistance change of 103, and above 500 °C with a resistance change exceeding 104. The mechanism of achieving low-temperature growth of VO2 epitaxial films was analyzed utilizing Thornton's zone model; finally, the epitaxial characteristics of VO2 on the sapphire substrate were confirmed from in-plane and out-of-plane directions. This work presents a guideline for the low-temperature growth of VO2 epitaxial films with enhanced phase-transition performance, thereby reducing both the cost and the requirements associated with the epitaxial growth of VO2 films. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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24. High‐Speed Short Infrared Detector Based on Vertical Gr/Se0.2Te0.8/GaAs Heterojunction.
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Yang, Chong, Yu, He, Lian, Yunlu, Liu, Yiming, Wu, Maoyi, Yang, Xiutao, Han, Jiayue, Dong, Xiang, Gou, Jun, Zheng, Xing, Wu, Zhiming, Jiang, Yadong, and Wang, Jun
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INFRARED detectors , *PHOTODETECTORS , *HETEROJUNCTIONS , *TELECOMMUNICATION , *INFRARED imaging , *CHARGE carrier mobility , *OPTICAL constants - Abstract
In the domain of high‐performance short‐wave infrared (SWIR) photodetection and imaging, existing technologies predominantly utilize single‐crystal germanium and III‐V semiconductors. Despite their efficacy, these materials are encumbered by laborious synthesis and complex fabrication demands. In this study, the synthesis of large‐area, high‐crystallinity Se0.2Te0.8 thin films through a CMOS‐compatible vacuum thermal evaporation process is reported. A high‐speed, broad‐spectrum photodetector engineered with an innovative Gr/Se0.2Te0.8/GaAs vertical heterostructure is presented, which capitalizes on the augmented carrier mobility and employs graphene innovatively as both a carrier collection interface and an electrode. This configuration facilitates a remarkably swift response time of 800 ns/1 µs at the crucial 1310 nm wavelength for optical communications. Moreover, the fabrication of a 5 × 5 array device demonstrates substantial SWIR imaging capabilities at ambient conditions, marking a paradigm shift in uncooled infrared imaging and communication technologies. This work not only extends the boundaries of SWIR photodetector performance but also underscores the potential of novel material systems in high‐speed optical applications. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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25. De‐nitrosylation Coordinates Appressorium Function for Infection of the Rice Blast Fungus.
- Author
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Hu, Hong, He, Wenhui, Qu, Zhiguang, Dong, Xiang, Ren, Zhiyong, Qin, Mengyuan, Liu, Hao, Zheng, Lu, Huang, Junbin, and Chen, Xiao‐Lin
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RICE blast disease , *PYRICULARIA oryzae , *CHEMICAL inhibitors , *PROTEIN structure , *MYCOSES - Abstract
As a signaling molecule, nitric oxide (NO) regulates the development and stress response in different organisms. The major biological activity of NO is protein S‐nitrosylation, whose function in fungi remains largely unclear. Here, it is found in the rice blast fungus Magnaporthe oryzae, de‐nitrosylation process is essential for functional appressorium formation during infection. Nitrosative stress caused by excessive accumulation of NO is harmful for fungal infection. While the S‐nitrosoglutathione reductase GSNOR‐mediated de‐nitrosylation removes excess NO toxicity during appressorium formation to promote infection. Through an indoTMT switch labeling proteomics technique, 741 S‐nitrosylation sites in 483 proteins are identified. Key appressorial proteins, such as Mgb1, MagB, Sps1, Cdc42, and septins, are activated by GSNOR through de‐nitrosylation. Removing S‐nitrosylation sites of above proteins is essential for proper protein structure and appressorial function. Therefore, GSNOR‐mediated de‐nitrosylation is an essential regulator for appressorium formation. It is also shown that breaking NO homeostasis by NO donors, NO scavengers, as well as chemical inhibitor of GSNOR, shall be effective methods for fungal disease control. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
26. Training data selection using information entropy: Application to heating load modeling of rural residence in northern China.
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Kang, Li-gai, Li, Hao, Wang, Zhi-chao, Sun, Dong-xiang, Wang, Jin-zhu, Yang, Yang, and Zhang, Xu
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HEAT pumps , *ENTROPY (Information theory) , *AIR source heat pump systems , *HEATING load , *HEAT capacity - Abstract
The selection of input variables and their amount has been an important issue in big data load forecasting. Taking heating load forecasting as an example, this paper proposed a method for data filtering based on information entropy. First, the heating data from an air source heat pump system adopted by a rural residence in northern China were employed. Moreover, the training data were classified based on linear or nonlinear variations of outdoor temperature and its changing ranges, while the validation data included three different types of weather conditions, namely, cold, cool, and mild. Then, the information entropy under 2-h, 4-h, 6-h and 8-h training window was quantified to be 1.811, 1.839, 1.877 and 1.856, respectively. For the employed rural residence, an equivalent three-resistance and two-capacity model was established to validate the effectiveness of the training window. Using the derived optimal thermal resistance and capacity, the various selection of outdoor temperature variation trend and range were compared and optimized. Results showed that 6 h of training data had the maximum information entropy and the most abundant information, the minimum errors between actual and forecasting data were observed under 6 h of training data, linear change, and lower outdoor temperature. The mean absolute percentage errors for the load forecasting of three typical days were 5.63%, 8.46%, and 12.10%, respectively. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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27. Simulation of radon detection efficiency with small pulse ionization chamber based on Geant4.
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Gou, Rui, Shi, Rui, Zhang, Qian, and Dong, Xiang-Long
- Subjects
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IONIZATION chambers , *RADON , *RADON detectors , *MONTE Carlo method , *BACKGROUND radiation - Abstract
Radon measurement is crucial in assessing the damage to the human body caused by natural radiation. Pulsed ionization chambers are effective for real-time radon measurement and have widespread applications in other radiation techniques. However, due to practical constraints such as limited space and portability concerns, it becomes imperative to consider not only the detection efficiency but also their ease of transportation. This work utilizes the Geant4 Monte Carlo simulation toolkit to characterize the detection models of small cylindrical and flat plate-type pulsed ionization chambers, and carry out a simulation study to analyze the three crucial factors that influence detection efficiency, including the geometry of the chamber, electrode size, and operating temperature. The results indicate that the cylindrical pulse ionization chamber, with a length of 8 cm and radius of 2 cm, has the best detection efficiency and portability in terms of geometric dimensions, achieving a detection efficiency of (58 ± 4)%. Meanwhile, the flat plate pulse ionization chamber, with dimensions of 7 cm in length and 3 cm in width, achieves the best detection efficiency and portability, with a detection efficiency of (54 ± 3)%. In terms of electrode wire size, the cylindrical ionization chamber electrode wire with a length of 7 cm and a radius of 2.5 mm was optimal with a detection efficiency of (59 ± 4)%. In terms of operating temperature, the detection efficiency of the flat-plate pulsed ionization chamber was the highest at 30 °C, which was (58 ± 4)%, and that of the cylindrical pulsed ionization chamber was the highest at 20 °C, which was (63 ± 4)%. By analyzing the influencing factors of the detection efficiency of the pulsed ionization chamber, it has a certain reference value and guiding significance for the research and design of small pulsed ionization chamber detectors for radon measuring instruments. • A portable small pulsed ionization chamber was studied for radon measurement. • The factors affecting detection efficiency for radon measurement were simulated base on the Geant4 toolkit. • A parameters scheme for the detection efficiency optimization of the ionization chamber under various factors was proposed. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
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