1. Highly sensitive photoelectrochemical sensors for multichannel detection and uniform bioimaging based on fireworks-like silicon nanowires and its heterojunctions fabricated by MACE and sputtering processes.
- Author
-
Cao, Shengli, Xiao, Gang, Wang, Haoxuan, Xie, Ziyu, Jiao, Yutao, Qin, Yuxiang, and Yue, Zhao
- Abstract
Photoelectrochemical (PEC) sensors have emerged as a promising candidate for biochemical detection. However, PEC sensors based on bulk semiconductors are limited by sensitivity and detection varieties, though they can provide uniform imaging; PEC sensors based on nanomaterials can meet the requirements of various analytes and sensitivity, but the inhomogeneity of their surface poses a challenge to imaging uniformity. In this work, metal-assisted chemical etching (MACE) and sputtering processes were used to directly fabricated PEC sensors with fireworks-like silicon nanowires (F-SiNWs) and their heterojunctions with excellent performance. Through regulating the etching and sputtering times, the structure and nanomaterials attachment of F-SiNWs can be well controlled. The photoelectric and sensing properties of F-SiNWs with different morphologies were investigated and optimized. Then, the sensor fabricated by optimal F-SiNWs can directly detect H 2 O 2 and indirectly detect glucose under negative bias, while directly detect dopamine (DA) under positive bias. The detection of these three analytes do not interfere with each other, contributing to an excellent multichannel detection system. Subsequently, the multichannel detection of various secretions (H 2 O 2 , DA and glucose) of PC-12 cells was achieved by the sensor. Finally, the imaging uniformity of the sensor was demonstrated in different solutions. PEC bioimaging was successfully applied to monitor enzyme activity by bioimaging gradients and cell survival by bioimaging distribution. These results demonstrate the high sensitivity in multichannel detection and excellent stability and homogeneity in bioimaging of the sensor. Therefore, MACE and sputtering process can be a promising tool for constructing PEC sensor. • MACE and sputtering processes were used for fabricating highly sensitive PEC sensor. • The structure of F-SiNWs/Ag was optimized by the etching and sputtering time. • The mechanism of MACE and sputtering processes enhancing PEC performance was studied. • Multichannel detection of H 2 O 2 , DA and glucose secreted by PC-12 cells was achieved. • PEC sensor achieved uniform bioimaging to study enzyme activity and cell survival. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF