1. Alteration of small intestinal occludin and ZO‐1 expession in liver cirrhosis.
- Author
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Voulgaris, Theodoros, Tiniakos, Dina, Karagiannakis, Dimitrios, Myoteri, Despoina, Karandrea, Despoina, Manolakopoulos, Spilios, Papatheodoridis, George, and Vlachogiannakos, Jiannis
- Subjects
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CIRRHOSIS of the liver , *CELIAC disease , *INTESTINAL barrier function , *HEPATORENAL syndrome - Abstract
This article, published in Pathology International, explores the alteration of small intestinal occludin and ZO-1 expression in liver cirrhosis. The study found that bacterial translocation (BT) plays a crucial role in the development of cirrhosis complications, and increased gut permeability is observed in patients with advanced fibrosis or cirrhosis. The authors evaluated intestinal integrity deregulation in cirrhotic patients and found that occludin and ZO-1 expression were disturbed compared to controls. They suggest that gut barrier deregulation in cirrhosis has a multifactorial etiology and that other mechanisms, in addition to tight junction alterations, are implicated in promoting BT in decompensated cirrhosis. [Extracted from the article]
- Published
- 2024
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