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• aircraft engine remaining useful life prediction method with the real engine flight data • multilayered deep convolutional neural network architecture and a long short-term memory network with regression output • comparison of the various deep neural network training options • analysis of the real turbofan engine operational data as an input data for the deep neural network, in order to train, validate and test machine learning algorithms in predicting engine remaining useful life • case studies for method verification based on the real-life engine operational data not the simulated one Aircraft Engine Remaining Useful Life is a key factor which strongly affects flight operations safety and flight operators business decisions. In the article authors decided to present the concept of engine remaining useful life prediction. Proposed method was created as a result of the analysis of the real turbofan engine operational data collected for a few years which was used as an input data for the deep neural network, in order to train, validate and test machine learning algorithms. Two architectures of deep neural networks were created: multilayered deep convolutional neural networks and a long short-term memory network with regression output. Both neural networks were trained, validated and tested on the same engine data and with a various network training options. Results were compared with the neural network performance metrics and figures presenting network prediction convergence. To present how the real-life engine dataset differs the results from the simulated data, both datasets were validated on the same neural network architectures. The main purpose of this article was to present the idea and method of how the artificial neural networks could be used to predict aircraft remaining useful life indicator on the real-life engine operational data not the simulated one. [ABSTRACT FROM AUTHOR]